DegronMD - Q6ZMY6(WDR88)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R441Q	TCGA-D6-A6EP	HNSC	TCGA	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441Q	TCGA-E6-A2P9	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441Q	DO52084	HNSC	ICGC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441Q	DO43714	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441Q	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441Q	ACH-002220	Lymphoma	CCLE	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441Q	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.N462K	DO233736	GACA	ICGC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.0833
p.G446V	DO229028	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.25
p.C440F	DO229034	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.0833
p.A449T	DO34448	PACA	ICGC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.R441W	SIDM01154	T-Lymphoblastic Leukemia	GDSC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441W	ACH-000953	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.R441W	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.T451I	SIDM00217	Colorectal Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7078
p.T451I	SNU-1040	large intestine	COSMIC	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7078
p.E461K	ACH-002509	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111

Kaplan plot for WDR88 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR88

UniProt ID: Q6ZMY6

Entrez ID: 126248

Protein name: WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for WDR88 in