DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IKENE
Uniprot ID:
Q9H2G2
Source protein:
STE20-like serine/threonine-protein kinase
Source gene:
SLK
Class:
DEG_APCC_KENBOX_2
Location:
419:423
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6842
ASA_SCORE:
104.58
COIL:
0.4936
CONS_SCORE:
0.2811
DSS_SCORE:
0.5651
HELIX:
0.506
FCONS_SCORE:
1.0169
RIG_SCORE:
0.7392
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SLK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IKENE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P25054
Adenomatous polyposis coli protein
DEG_APCC_KENBOX_2
2615:2619
IKENE
APC,CDC20,FZR1
0.9967
More...
Q6XYQ8
Synaptotagmin-10
DEG_APCC_KENBOX_2
116:120
IKENE
APC,CDC20,FZR1
0.6234
More...
Q9H2G2
STE20-like serine/threonine-protein kinase
DEG_APCC_KENBOX_2
419:423
IKENE
APC,CDC20,FZR1
0.6842
More...