DegronMD - Q8IUR6(CREBRF)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K216N	TCGA-06-5416	GBM	TCGA	PTSST	DEG_SPOP_SBC_1	207:211	Mutation substituting flanking lysine	0.3056
p.K216N	DO10880	GBM	ICGC	PTSST	DEG_SPOP_SBC_1	207:211	Mutation substituting flanking lysine	0.3056
p.R249W	TCGA-A5-A0G2	UCEC	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8634
p.R249W	TCGA-FD-A6TH	BLCA	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8634
p.R249W	DO49763	BLCA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8634
p.R249W	DO41235	UCEC	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8634
p.Y220H	TCGA-AA-3663	COAD	TCGA	PTSST	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.Y220H	DO9346	COAD	ICGC	PTSST	DEG_SPOP_SBC_1	207:211	Mutation rewiring degron network	0.0833
p.V515F	TCGA-AG-A002	READ	TCGA	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation altering degron motif	0.5957
p.K507N	TCGA-AO-A0JC	BRCA	TCGA	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation substituting flanking lysine	0.3056
p.R503L	TCGA-EE-A2GK	SKCM	TCGA	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.0833
p.R503W	TCGA-EE-A2GO	SKCM	TCGA	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.0833
p.S253C	TCGA-FC-A6HD	PRAD	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.643
p.S253C	DO46799	PRAD	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.643
p.H256Y	TCGA-GC-A3WC	BLCA	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6118
p.H256Y	DO755	BLCA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6118
p.R249L	DO48402	BLCA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8428
p.R249L	DO229035	LICA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.8428
p.K509N	DO5277	BRCA	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.25
p.S526P	DO229363	BTCA	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.0833
p.S518R	DO228087	EOPC	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.3056
p.E519D	DO228948	LICA	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.2778
p.P514S	DO220886	MELA	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation altering degron motif	0.6752
p.R505W	DO37823	SKCM	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1389
p.R505L	DO37738	SKCM	ICGC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1389
p.N506K	SIDM00181	Bladder Carcinoma	GDSC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1667
p.N506K	SIDM01646	Non-Cancerous	GDSC	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1667
p.N506K	ACH-002358	Non-Cancerous	CCLE	LTPVSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1667
p.P244L	SIDM00171	Colorectal Carcinoma	GDSC	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.2222
p.P244L	ACH-000412	Colon/Colorectal Cancer	CCLE	SRPLLSQIH	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.2222

Kaplan plot for CREBRF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CREBRF

UniProt ID: Q8IUR6

Entrez ID: 153222

Protein name: CREB3 regulatory factor (Luman recruitment factor) (LRF)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CREBRF in