DegronMD

Uniprot ID: Q8IUR6

Source protein: CREB3 regulatory factor

Source gene: CREBRF

Class: DEG_SCF_FBW7_2

Location: 512:517

E3 ligase: FBXW7

DEGRON score: 0.6536

ASA_SCORE: 66.6333

COIL: 0.729

CONS_SCORE: 0.7107

DSS_SCORE: 0.3533

HELIX: 0.2073

FCONS_SCORE: 0.9744

RIG_SCORE: 0.7637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V515F	TCGA-AG-A002	READ	TCGA	LTPVSE	DEG_SCF_FBW7_2	0.5957
p.K507N	TCGA-AO-A0JC	BRCA	TCGA	LTPVSE	DEG_SCF_FBW7_2	0.3056
p.R503L	TCGA-EE-A2GK	SKCM	TCGA	LTPVSE	DEG_SCF_FBW7_2	0.0833
p.R503W	TCGA-EE-A2GO	SKCM	TCGA	LTPVSE	DEG_SCF_FBW7_2	0.0833
p.K509N	DO5277	BRCA	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.25
p.S526P	DO229363	BTCA	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.0833
p.S518R	DO228087	EOPC	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.3056
p.E519D	DO228948	LICA	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.2778
p.P514S	DO220886	MELA	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.6752
p.R505W	DO37823	SKCM	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.1389
p.R505L	DO37738	SKCM	ICGC	LTPVSE	DEG_SCF_FBW7_2	0.1389
p.N506K	SIDM00181	Bladder Carcinoma	GDSC	LTPVSE	DEG_SCF_FBW7_2	0.1667
p.N506K	SIDM01646	Non-Cancerous	GDSC	LTPVSE	DEG_SCF_FBW7_2	0.1667
p.N506K	ACH-002358	Non-Cancerous	CCLE	LTPVSE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUR6	CREB3 regulatory factor	DEG_SCF_FBW7_2	512:517	LTPVSE	FBXW7	0.6536	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons