DegronMD

Uniprot ID: Q8IUR6

Source protein: CREB3 regulatory factor

Source gene: CREBRF

Class: DEG_APCC_DBOX_1

Location: 248:256

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6576

ASA_SCORE: 93.3444

COIL: 0.7797

CONS_SCORE: 0.3847

DSS_SCORE: 0.4339

HELIX: 0.1277

FCONS_SCORE: 1.016

RIG_SCORE: 0.7625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R249W	TCGA-A5-A0G2	UCEC	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	0.8634
p.R249W	TCGA-FD-A6TH	BLCA	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	0.8634
p.R249W	DO49763	BLCA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	0.8634
p.R249W	DO41235	UCEC	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	0.8634
p.S253C	TCGA-FC-A6HD	PRAD	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	0.643
p.S253C	DO46799	PRAD	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	0.643
p.H256Y	TCGA-GC-A3WC	BLCA	TCGA	SRPLLSQIH	DEG_APCC_DBOX_1	0.6118
p.H256Y	DO755	BLCA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	0.6118
p.R249L	DO48402	BLCA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	0.8428
p.R249L	DO229035	LICA	ICGC	SRPLLSQIH	DEG_APCC_DBOX_1	0.8428
p.P244L	SIDM00171	Colorectal Carcinoma	GDSC	SRPLLSQIH	DEG_APCC_DBOX_1	0.2222
p.P244L	ACH-000412	Colon/Colorectal Cancer	CCLE	SRPLLSQIH	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUR6	CREB3 regulatory factor	DEG_APCC_DBOX_1	248:256	SRPLLSQIH	APC,CDC20,FZR1	0.6576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons