DegronMD - Q5MJ09(SPANXN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S134C	TCGA-24-1435	OV	TCGA	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S134C	DO31370	OV	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S15T	TCGA-44-2668	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.S15T	DO25232	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.T5N	TCGA-44-A4SU	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.5944
p.T5N	TCGA-OR-A5L2	ACC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.5944
p.T5N	DO24507	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.5944
p.T13A	TCGA-55-5899	LUAD	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.T13A	DO26042	LUAD	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.G129V	TCGA-85-A4QR	LUSC	TCGA	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129V	DO45523	LUSC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129S	TCGA-A5-A0G1	UCEC	TCGA	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129S	DO42472	UCEC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.T13S	TCGA-BR-4292	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.T13S	DO38495	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1944
p.S6F	TCGA-EE-A2MD	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7982
p.S6F	DO222434	MELA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7982
p.S6F	DO37851	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7982
p.P4L	TCGA-EE-A3J5	SKCM	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7582
p.P4L	DO47331	SKCM	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7582
p.S134F	TCGA-EE-A3JD	SKCM	TCGA	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S134F	DO50299	SKCM	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S15N	TCGA-EO-A22R	UCEC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.S15N	DO42713	UCEC	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.S134T	TCGA-GN-A4U8	SKCM	TCGA	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S134T	DO47320	SKCM	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.E132Q	TCGA-IG-A4P3	ESCA	TCGA	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.25
p.E18K	TCGA-L5-A43C	ESCA	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556
p.E18K	SIDM00193	Colorectal Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556
p.E18K	ACH-000991	Colon/Colorectal Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556
p.E18K	SNU-81	large intestine	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556
p.G10V	TCGA-OR-A5KB	ACC	TCGA	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.S7C	DO225002	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7541
p.E126G	DO222501	COCA	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.0833
p.G129A	DO50320	ESAD	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129A	SIDM00497	Colorectal Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129A	ACH-000683	Colon/Colorectal Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.S7R	DO229009	LICA	ICGC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7427
p.G133R	DO220903	MELA	ICGC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.2778
p.P16S	SIDM00453	Pancreatic Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.P16S	ACH-000023	Pancreatic Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.P16S	PA-TU-8988T	pancreas	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.S134Y	SIDM00646	Small Cell Lung Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S134Y	ACH-000129	Lung Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.S134Y	NCI-H1341	lung	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.3056
p.G129C	SIDM00596	Endometrial Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129C	ACH-001517	Endometrial/Uterine Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.G129C	HEC-1	endometrium	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	135:140	Mutation rewiring degron network	0.1667
p.S6P	SIDM01045	Endometrial Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.6752
p.S6P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.6752
p.S6P	EN	endometrium	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.6752
p.E18D	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556
p.E18D	ACH-001362	Lung Cancer	CCLE	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556
p.E18D	NCI-H1770	lung	COSMIC	PTSST	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPANXN3

UniProt ID: Q5MJ09

Entrez ID: 139067

Protein name: Sperm protein associated with the nucleus on the X chromosome N3 (Nuclear-associated protein SPAN-Xn3) (SPANX-N3) (SPANX family member N3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPANXN3 in