DegronMD

Uniprot ID: Q5MJ09

Source protein: Sperm protein associated with the nucleus on the X chromosome N3

Source gene: SPANXN3

Class: DEG_Kelch_Keap1_1

Location: 135:140

E3 ligase: KEAP1

DEGRON score: 0.9718

ASA_SCORE: 101.9167

COIL: 0.9233

CONS_SCORE: 1

DSS_SCORE: 0.9868

HELIX: 0.062

FCONS_SCORE: 1.1075

RIG_SCORE: 0.5443

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S134C	TCGA-24-1435	OV	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.S134C	DO31370	OV	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.G129V	TCGA-85-A4QR	LUSC	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129V	DO45523	LUSC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129S	TCGA-A5-A0G1	UCEC	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129S	DO42472	UCEC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.S134F	TCGA-EE-A3JD	SKCM	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.S134F	DO50299	SKCM	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.S134T	TCGA-GN-A4U8	SKCM	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.S134T	DO47320	SKCM	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.E132Q	TCGA-IG-A4P3	ESCA	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.25
p.E126G	DO222501	COCA	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.0833
p.G129A	DO50320	ESAD	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129A	SIDM00497	Colorectal Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129A	ACH-000683	Colon/Colorectal Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G133R	DO220903	MELA	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.2778
p.S134Y	SIDM00646	Small Cell Lung Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.S134Y	ACH-000129	Lung Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.S134Y	NCI-H1341	lung	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.3056
p.G129C	SIDM00596	Endometrial Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129C	ACH-001517	Endometrial/Uterine Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	0.1667
p.G129C	HEC-1	endometrium	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF01	Arginine/serine-rich protein PNISR	DEG_Kelch_Keap1_1	128:133	SQDSGE	KEAP1	0.9947	More...
Q5MJ09	Sperm protein associated with the nucleus on the X chromosome N3	DEG_Kelch_Keap1_1	135:140	SQDSGE	KEAP1	0.9718	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons