DegronMD

Uniprot ID: Q8TF01

Source protein: Arginine/serine-rich protein PNISR

Source gene: PNISR

Class: DEG_Kelch_Keap1_1

Location: 128:133

E3 ligase: KEAP1

DEGRON score: 0.9947

ASA_SCORE: 72.9667

COIL: 0.8502

CONS_SCORE: 0.7836

DSS_SCORE: 0.8193

HELIX: 0.1143

FCONS_SCORE: 1.0769

RIG_SCORE: 0.5621

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P121H	TCGA-AA-A010	COAD	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.1389
p.A135S	TCGA-CD-8533	STAD	TCGA	SQDSGE	DEG_Kelch_Keap1_1	0.2778
p.A135S	DO47795	STAD	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.2778
p.N143K	DO228974	LICA	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.0556
p.I141V	DO23120	LINC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.N138S	DO42673	UCEC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	0.1944
p.I141M	SIDM00435	Acute Myeloid Leukemia	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM00588	Oral Cavity Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM00607	Glioblastoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM00465	Ovarian Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM00358	Gastric Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM00026	Other Solid Cancers	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM01448	Head and Neck Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	SIDM01588	Endometrial Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	RERF-GC-1B	stomach	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	ABC-1	lung	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	TASK1	bone	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	KNS-42	central_nervous_system	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	OVMIU	ovary	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.I141M	HSC-4	upper_aerodigestive_tract	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.Q129H	SIDM00285	Neuroblastoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.647
p.Q129H	ACH-001338	Neuroblastoma	CCLE	SQDSGE	DEG_Kelch_Keap1_1	0.647
p.Q129H	CHP-134	autonomic_ganglia	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.647
p.V120A	SIDM00118	Colorectal Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.V120A	ACH-001081	Colon/Colorectal Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	0.1111
p.V120A	HCC2998	large_intestine	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF01	Arginine/serine-rich protein PNISR	DEG_Kelch_Keap1_1	128:133	SQDSGE	KEAP1	0.9947	More...
Q5MJ09	Sperm protein associated with the nucleus on the X chromosome N3	DEG_Kelch_Keap1_1	135:140	SQDSGE	KEAP1	0.9718	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SQDSGE

Degron related mutations and impact score

Drug responses associated with PNISR mutations

All proteins holding degron of SQDSGE