DegronMD - Q8TF01(PNISR)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P121H	TCGA-AA-A010	COAD	TCGA	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1389
p.T527I	TCGA-AP-A1DK	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation blocking phosphorylation signal	0.6667
p.T527I	DO42033	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation blocking phosphorylation signal	0.6667
p.S533N	TCGA-BS-A0UV	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.818
p.S533N	DO42793	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.818
p.A135S	TCGA-CD-8533	STAD	TCGA	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.2778
p.A135S	DO47795	STAD	ICGC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.2778
p.N143K	DO228974	LICA	ICGC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.0556
p.T530N	DO229034	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation blocking phosphorylation signal	0.75
p.I141V	DO23120	LINC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.R544H	DO34264	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0833
p.S525R	DO35242	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1667
p.T524A	DO38404	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation blocking phosphorylation signal	0.5833
p.N138S	DO42673	UCEC	ICGC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1944
p.I141M	SIDM00435	Acute Myeloid Leukemia	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM00588	Oral Cavity Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM00607	Glioblastoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM00465	Ovarian Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM00358	Gastric Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM00026	Other Solid Cancers	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM01448	Head and Neck Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	SIDM01588	Endometrial Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	RERF-GC-1B	stomach	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	ABC-1	lung	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	TASK1	bone	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	KNS-42	central nervous system	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	OVMIU	ovary	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.I141M	HSC-4	upper aerodigestive tract	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.Q129H	SIDM00285	Neuroblastoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation altering degron motif	0.647
p.Q129H	ACH-001338	Neuroblastoma	CCLE	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation altering degron motif	0.647
p.Q129H	CHP-134	autonomic ganglia	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation altering degron motif	0.647
p.S522N	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation blocking phosphorylation signal	0.5278
p.V120A	SIDM00118	Colorectal Carcinoma	GDSC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.V120A	ACH-001081	Colon/Colorectal Cancer	CCLE	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.V120A	HCC2998	large intestine	COSMIC	SQDSGE	DEG_Kelch_Keap1_1	128:133	Mutation rewiring degron network	0.1111
p.S533G	ACH-002026	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.8104

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNISR

UniProt ID: Q8TF01

Entrez ID: 25957

Protein name: Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNISR in