DegronMD

Uniprot ID: Q00587

Source protein: Cdc42 effector protein 1

Source gene: CDC42EP1

Class: DEG_SCF_TRCP1_1

Location: 157:162

E3 ligase: BTRC

DEGRON score: 0.9883

ASA_SCORE: 63.55

COIL: 0.8293

CONS_SCORE: 0.6586

DSS_SCORE: 0.4757

HELIX: 0.0855

FCONS_SCORE: 0.9468

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R165C	TCGA-66-2792	LUSC	TCGA	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.R165C	DO26451	LUSC	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.R165S	TCGA-A5-A0G2	UCEC	TCGA	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.R165S	DO41235	UCEC	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.P172S	TCGA-EE-A29X	SKCM	TCGA	DSGFCT	DEG_SCF_TRCP1_1	0.0556
p.P172S	DO222510	MELA	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.0556
p.P172S	DO37595	SKCM	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.0556
p.P172L	TCGA-VQ-AA6D	STAD	TCGA	DSGFCT	DEG_SCF_TRCP1_1	0.0556
p.P172L	DO222392	STAD	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.0556
p.S169L	DO52511	EOPC	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.1389
p.R165L	DO229045	LICA	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.S169P	DO33070	PACA	ICGC	DSGFCT	DEG_SCF_TRCP1_1	0.1389
p.R168H	SIDM00588	Oral Cavity Carcinoma	GDSC	DSGFCT	DEG_SCF_TRCP1_1	0.1667
p.R168H	HSC-4	upper_aerodigestive_tract	COSMIC	DSGFCT	DEG_SCF_TRCP1_1	0.1667
p.L156M	SIDM00789	Colorectal Carcinoma	GDSC	DSGFCT	DEG_SCF_TRCP1_1	0.3056
p.L156M	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGFCT	DEG_SCF_TRCP1_1	0.3056
p.L156M	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGFCT	DEG_SCF_TRCP1_1	0.3056
p.L156M	HCT-15	large_intestine	COSMIC	DSGFCT	DEG_SCF_TRCP1_1	0.3056
p.R165H	SIDM00596	Endometrial Carcinoma	GDSC	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.R165H	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGFCT	DEG_SCF_TRCP1_1	0.25
p.R165H	HEC-1	endometrium	COSMIC	DSGFCT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00587	Cdc42 effector protein 1	DEG_SCF_TRCP1_1	157:162	DSGFCT	BTRC	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons