DegronMD

Uniprot ID: Q96P47

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Source gene: AGAP3

Class: DEG_SCF_FBW7_1

Location: 303:310

E3 ligase: FBXW7

DEGRON score: 0.944

ASA_SCORE: 78.0625

COIL: 0.8808

CONS_SCORE: 0.3643

DSS_SCORE: 0.5017

HELIX: 0.0616

FCONS_SCORE: 0.998

RIG_SCORE: 0.6442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V311M	TCGA-AP-A059	UCEC	TCGA	VPSTPSIS	DEG_SCF_FBW7_1	0.3056
p.V311M	DO41361	UCEC	ICGC	VPSTPSIS	DEG_SCF_FBW7_1	0.3056
p.G297R	TCGA-VQ-A8P2	STAD	TCGA	VPSTPSIS	DEG_SCF_FBW7_1	0.1667
p.G297R	DO51761	STAD	ICGC	VPSTPSIS	DEG_SCF_FBW7_1	0.1667
p.L294V	DO220912	MELA	ICGC	VPSTPSIS	DEG_SCF_FBW7_1	0.0833
p.V319M	SIDM00971	Breast Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	0.0833
p.A314T	SIDM00251	Gastric Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	0.2222
p.A314T	SIDM00161	Biliary Tract Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	0.2222
p.A314T	TGBC11TKB	stomach	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	0.2222
p.V311L	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VPSTPSIS	DEG_SCF_FBW7_1	0.3056
p.A295V	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPSTPSIS	DEG_SCF_FBW7_1	0.1111
p.S297N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	0.1667
p.P306S	NCI-H2172	lung	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	0.6752
p.R303H	RL95-2	endometrium	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	0.8244
p.R315C	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTPSIS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SCF_FBW7_1	303:310	VPSTPSIS	FBXW7	0.944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons