DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SPOP_SBC_1

Location: 248:252

E3 ligase: SPOP

DEGRON score: 0.8247

ASA_SCORE: 89.4

COIL: 0.9488

CONS_SCORE: 0.1616

DSS_SCORE: 0.7476

HELIX: 0.0304

FCONS_SCORE: 0.4039

RIG_SCORE: 0.5318

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S250F	TCGA-L5-A4OT	ESCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.7982
p.S251F	SIDM00545	Melanoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.7982
p.S251F	ACH-000987	Skin Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	0.7982
p.S251F	Mewo	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7982
p.L249P	DO228612	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6471
p.L249P	DO225404	LAML	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6471
p.L249P	DO228941	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6471
p.L249P	DO228942	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6471
p.L249P	DO229053	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6471
p.L249P	DO229240	THCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6471
p.A253T	TCGA-HQ-A5ND	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.3056
p.A253T	DO51899	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.P254Q	TCGA-A8-A07J	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.2778
p.P254S	DO222550	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.T245S	TCGA-VS-A8QC	CESC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.25
p.T245S	DO51628	CESC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.25
p.P255R	DO225002	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A259D	TCGA-E7-A4IJ	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.1389
p.A259D	DO453	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 19 of 19 entries

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Drug responses associated with MUC7 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PLSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60825	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	DEG_SPOP_SBC_1	469:473	PLSSS	SPOP	0.9968	More...
O00763	Acetyl-CoA carboxylase 2	DEG_SPOP_SBC_1	103:107	PLSSS	SPOP	0.9873	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	69:73	PLSSS	SPOP	0.8794	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	478:482	PLSSS	SPOP	0.779	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	1226:1230	PLSSS	SPOP	0.982	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	77:81	PLSSS	SPOP	0.9962	More...
P04637	Cellular tumor antigen p53	DEG_SPOP_SBC_1	92:96	PLSSS	SPOP	0.9977	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	247:251	PLSSS	SPOP	0.9926	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	615:619	PLSSS	SPOP	0.9976	More...
Q9NS37	CREB/ATF bZIP transcription factor	DEG_SPOP_SBC_1	129:133	PLSSS	SPOP	0.9398	More...
Q9P2B4	CTTNBP2 N-terminal-like protein	DEG_SPOP_SBC_1	405:409	PLSSS	SPOP	0.9931	More...
Q2TBE0	CWF19-like protein 2	DEG_SPOP_SBC_1	388:392	PLSSS	SPOP	0.9997	More...
Q9Y4D2	Diacylglycerol lipase-alpha	DEG_SPOP_SBC_1	993:997	PLSSS	SPOP	0.7658	More...
P11388	DNA topoisomerase 2-alpha	DEG_SPOP_SBC_1	1389:1393	PLSSS	SPOP	0.9972	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1507:1511	PLSSS	SPOP	0.9967	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	829:833	PLSSS	SPOP	0.9934	More...
Q9ULK0	Glutamate receptor ionotropic, delta-1	DEG_SPOP_SBC_1	954:958	PLSSS	SPOP	0.9853	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	288:292	PLSSS	SPOP	0.9368	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1434:1438	PLSSS	SPOP	0.9226	More...
Q9UBC0	Hepatocyte nuclear factor 6	DEG_SPOP_SBC_1	181:185	PLSSS	SPOP	0.5617	More...
Q92993	Histone acetyltransferase KAT5	DEG_SPOP_SBC_1	133:137	PLSSS	SPOP	0.9685	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	311:315	PLSSS	SPOP	0.9014	More...
P14316	Interferon regulatory factor 2	DEG_SPOP_SBC_1	312:316	PLSSS	SPOP	0.9872	More...
Q8N9Z9	Lamin tail domain-containing protein 1	DEG_SPOP_SBC_1	35:39	PLSSS	SPOP	0.8742	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	114:118	PLSSS	SPOP	0.9937	More...

Showing 1 to 25 of 59 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSSS

Degron related mutations and impact score

Drug responses associated with MUC7 mutations

All proteins holding degron of PLSSS