DegronMD - O00763(ACACB)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K235N	TCGA-37-4130	LUSC	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.6918
p.K235N	DO228952	LICA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.6918
p.K235N	DO26490	LUSC	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.6918
p.H239N	TCGA-43-8115	LUSC	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation altering degron motif	0.7423
p.H239N	TCGA-43-8115	LUSC	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.7423
p.H239N	DO26440	LUSC	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation altering degron motif	0.7423
p.H239N	DO26440	LUSC	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.7423
p.I879N	TCGA-59-2363	OV	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.0556
p.I879N	DO29730	OV	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.0556
p.R213C	TCGA-75-7027	LUAD	TCGA	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.719
p.R213C	DO24811	LUAD	ICGC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.719
p.R218M	TCGA-A5-A1OF	UCEC	TCGA	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.3056
p.R218M	DO42568	UCEC	ICGC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.3056
p.G882C	TCGA-A8-A08J	BRCA	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.1389
p.G882C	DO2737	BRCA	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.1389
p.D241Y	TCGA-AA-3984	COAD	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation altering degron motif	0.7325
p.D241Y	TCGA-AA-3984	COAD	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.7325
p.D241Y	DO9002	COAD	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation altering degron motif	0.7325
p.D241Y	DO9002	COAD	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.7325
p.R231Q	TCGA-AA-A01R	COAD	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231Q	TCGA-AA-A01R	COAD	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.R231Q	DO7934	COAD	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231Q	DO7934	COAD	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.R231Q	SIDM00498	Colorectal Carcinoma	GDSC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231Q	SIDM00498	Colorectal Carcinoma	GDSC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.R231Q	ACH-000970	Colon/Colorectal Cancer	CCLE	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231Q	ACH-000970	Colon/Colorectal Cancer	CCLE	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.R231Q	SNU-C5	large intestine	COSMIC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231Q	SNU-C5	large intestine	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.S107G	TCGA-AB-2808	LAML	TCGA	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6993
p.S107G	DO21487	LAML	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6993
p.T243A	TCGA-AJ-A3EL	UCEC	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.2778
p.T243A	TCGA-AJ-A3EL	UCEC	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2778
p.T243A	DO41542	UCEC	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.2778
p.T243A	DO41542	UCEC	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2778
p.K890N	TCGA-AP-A1DK	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation altering degron motif	0.6918
p.K890N	DO42033	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation altering degron motif	0.6918
p.P99H	TCGA-AX-A1C5	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2222
p.P99H	DO41422	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2222
p.P894L	TCGA-BC-A10R	LIHC	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.3056
p.P894L	DO22962	LIHC	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.3056
p.K98R	TCGA-BR-8589	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation substituting flanking lysine	0.3056
p.K98R	DO47813	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation substituting flanking lysine	0.3056
p.V214I	TCGA-BS-A0UF	UCEC	TCGA	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.7076
p.V214I	DO41488	UCEC	ICGC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.7076
p.V214I	SIDM00835	Colorectal Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.7076
p.V214I	ACH-000489	Colon/Colorectal Cancer	CCLE	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.7076
p.V214I	SW1116	large intestine	COSMIC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.7076
p.D893Y	TCGA-BS-A0UJ	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation altering degron motif	0.6214
p.D893Y	DO42745	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation altering degron motif	0.6214
p.P103S	TCGA-D3-A8GQ	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6752
p.P103S	DO51246	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6752
p.R185C	TCGA-D5-6529	COAD	TCGA	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1389
p.R185C	DO10758	COAD	ICGC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1389
p.R185C	DO233865	GACA	ICGC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1389
p.R185C	SIDM01706	Hodgkin's Lymphoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1389
p.R185C	ACH-001093	Non-Cancerous	CCLE	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.1389
p.E249K	TCGA-FD-A6TC	BLCA	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1111
p.E249K	TCGA-FD-A6TC	BLCA	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1111
p.E249K	TCGA-IB-7651	PAAD	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1111
p.E249K	TCGA-IB-7651	PAAD	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1111
p.E249K	DO49755	BLCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1111
p.E249K	DO49755	BLCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1111
p.E249K	DO46657	PAAD	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1111
p.E249K	DO46657	PAAD	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1111
p.T243N	TCGA-FG-A87Q	LGG	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.2778
p.T243N	TCGA-FG-A87Q	LGG	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2778
p.T243N	DO51830	LGG	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.2778
p.T243N	DO51830	LGG	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2778
p.A198V	TCGA-FI-A2D5	UCEC	TCGA	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.5825
p.A198V	DO41331	UCEC	ICGC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.5825
p.T885M	TCGA-IB-7651	PAAD	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.2222
p.T885M	DO46657	PAAD	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.2222
p.A248T	TCGA-L5-A4OF	ESCA	TCGA	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1389
p.A248T	TCGA-L5-A4OF	ESCA	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1389
p.A248T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1389
p.A248T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1389
p.A248T	ACH-000995	Leukemia	CCLE	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1389
p.A248T	ACH-000995	Leukemia	CCLE	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1389
p.A248T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1389
p.A248T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1389
p.D893A	TCGA-XU-A92V	THYM	TCGA	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation altering degron motif	0.6682
p.R231W	DO225120	BRCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231W	DO225120	BRCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.R231W	DO227903	BRCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1944
p.R231W	DO227903	BRCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.2222
p.H239Y	DO225337	BRCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation altering degron motif	0.6118
p.H239Y	DO225337	BRCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.6118
p.G223E	DO227987	COCA	ICGC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.1667
p.D893N	DO224735	COCA	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation altering degron motif	0.5821
p.R898K	DO222798	COCA	ICGC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.1944
p.A109T	DO222657	ESCA	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.2778
p.S107T	DO233290	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6005
p.A248S	DO229019	LICA	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1389
p.A248S	DO229019	LICA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1389
p.A248S	DO229032	LICA	ICGC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1389
p.A248S	DO229032	LICA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1389
p.P103L	DO220877	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.7582
p.S95F	DO222749	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation blocking phosphorylation signal	0.5556
p.P215S	DO222753	MELA	ICGC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.6752
p.R193L	DO32817	PACA	ICGC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8428
p.R193L	SIDM01135	Pancreatic Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8428
p.R193L	ACH-000060	Pancreatic Cancer	CCLE	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8428
p.R193L	PANC-10-05	pancreas	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8428
p.R193W	SIDM02041	Colorectal Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.8634
p.R189Q	SIDM00831	Head and Neck Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.25
p.R189Q	SIDM00797	Melanoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.25
p.R189Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.25
p.R189Q	SIDM00044	Head and Neck Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.25
p.P219L	SIDM00064	Hepatocellular Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.2778
p.P219L	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.2778
p.P219L	SIDM00368	Small Cell Lung Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.2778
p.P219L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.2778
p.Q97H	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1667
p.Q97H	ACH-000733	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1667
p.Q97H	NCI-H1838	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1667
p.A902V	SIDM00864	Cervical Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.0833
p.A902V	ACH-001341	Cervical Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.0833
p.A902V	DoTc2-4510	cervix	COSMIC	EKEND	DEG_APCC_KENBOX_2	889:893	Mutation rewiring degron network	0.0833
p.S200C	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7541
p.S200C	ACH-000855	Esophageal Cancer	CCLE	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7541
p.S200C	KYSE-150	oesophagus	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.7541
p.G182D	ACH-001369	Ovarian Cancer	CCLE	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.0556
p.S106Y	ACH-002041	Thyroid Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.712
p.V199A	8305C	thyroid	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation altering degron motif	0.6936
p.A210S	NCI-H322M	lung	COSMIC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.6477
p.A210T	Farage	haematopoietic and lymphoid tissue	COSMIC	EAETRVPTM	DEG_COP1_1	209:217	Mutation altering degron motif	0.6028
p.E102D	CCK-81	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.3056
p.E241K	CAL-33	upper aerodigestive tract	COSMIC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation altering degron motif	0.7022
p.E241K	CAL-33	upper aerodigestive tract	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation altering degron motif	0.7022
p.T202M	HT-29	large intestine	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	192:200	Mutation rewiring degron network	0.2778
p.T202M	HT-29	large intestine	COSMIC	EAETRVPTM	DEG_COP1_1	209:217	Mutation rewiring degron network	0.1389
p.E230Q	HCC1599	breast	COSMIC	LDLHRD	LIG_APCC_ABBA_1	236:241	Mutation rewiring degron network	0.1667
p.E230Q	HCC1599	breast	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	235:241	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACACB

UniProt ID: O00763

Entrez ID: 32

Protein name: Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ACACB in