DegronMD

Uniprot ID: O00763

Source protein: Acetyl-CoA carboxylase 2

Source gene: ACACB

Class: DEG_COP1_1

Location: 209:217

E3 ligase: COP1

DEGRON score: 0.7835

ASA_SCORE: 91.2222

COIL: 0.8102

CONS_SCORE: 0.2431

DSS_SCORE: 0.5325

HELIX: 0.1337

FCONS_SCORE: 0.9372

RIG_SCORE: 0.7326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R213C	TCGA-75-7027	LUAD	TCGA	EAETRVPTM	DEG_COP1_1	0.719
p.R213C	DO24811	LUAD	ICGC	EAETRVPTM	DEG_COP1_1	0.719
p.R218M	TCGA-A5-A1OF	UCEC	TCGA	EAETRVPTM	DEG_COP1_1	0.3056
p.R218M	DO42568	UCEC	ICGC	EAETRVPTM	DEG_COP1_1	0.3056
p.V214I	TCGA-BS-A0UF	UCEC	TCGA	EAETRVPTM	DEG_COP1_1	0.7076
p.V214I	DO41488	UCEC	ICGC	EAETRVPTM	DEG_COP1_1	0.7076
p.V214I	SIDM00835	Colorectal Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	0.7076
p.V214I	ACH-000489	Colon/Colorectal Cancer	CCLE	EAETRVPTM	DEG_COP1_1	0.7076
p.V214I	SW1116	large_intestine	COSMIC	EAETRVPTM	DEG_COP1_1	0.7076
p.G223E	DO227987	COCA	ICGC	EAETRVPTM	DEG_COP1_1	0.1667
p.P215S	DO222753	MELA	ICGC	EAETRVPTM	DEG_COP1_1	0.6752
p.P219L	SIDM00064	Hepatocellular Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	0.2778
p.P219L	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	0.2778
p.P219L	SIDM00368	Small Cell Lung Carcinoma	GDSC	EAETRVPTM	DEG_COP1_1	0.2778
p.P219L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	EAETRVPTM	DEG_COP1_1	0.2778
p.A210S	NCI-H322M	lung	COSMIC	EAETRVPTM	DEG_COP1_1	0.6477
p.A210T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	EAETRVPTM	DEG_COP1_1	0.6028
p.T202M	HT-29	large_intestine	COSMIC	EAETRVPTM	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_COP1_1	209:217	EAETRVPTM	COP1	0.7835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons