DegronMD

Uniprot ID: O00763

Source protein: Acetyl-CoA carboxylase 2

Source gene: ACACB

Class: LIG_APCC_ABBA_1

Location: 236:241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5486

ASA_SCORE: 95.2167

COIL: 0.6823

CONS_SCORE: 0.269

DSS_SCORE: 0.3582

HELIX: 0.2863

FCONS_SCORE: 0.8543

RIG_SCORE: 0.7906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H239N	TCGA-43-8115	LUSC	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.7423
p.H239N	DO26440	LUSC	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.7423
p.D241Y	TCGA-AA-3984	COAD	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.7325
p.D241Y	DO9002	COAD	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.7325
p.R231Q	TCGA-AA-A01R	COAD	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.R231Q	DO7934	COAD	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.R231Q	SIDM00498	Colorectal Carcinoma	GDSC	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.R231Q	ACH-000970	Colon/Colorectal Cancer	CCLE	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.R231Q	SNU-C5	large_intestine	COSMIC	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.T243A	TCGA-AJ-A3EL	UCEC	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.2778
p.T243A	DO41542	UCEC	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.2778
p.E249K	TCGA-FD-A6TC	BLCA	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.1111
p.E249K	TCGA-IB-7651	PAAD	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.1111
p.E249K	DO49755	BLCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1111
p.E249K	DO46657	PAAD	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1111
p.T243N	TCGA-FG-A87Q	LGG	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.2778
p.T243N	DO51830	LGG	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.2778
p.A248T	TCGA-L5-A4OF	ESCA	TCGA	LDLHRD	LIG_APCC_ABBA_1	0.1389
p.A248T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LDLHRD	LIG_APCC_ABBA_1	0.1389
p.A248T	ACH-000995	Leukemia	CCLE	LDLHRD	LIG_APCC_ABBA_1	0.1389
p.A248T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LDLHRD	LIG_APCC_ABBA_1	0.1389
p.R231W	DO225120	BRCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.R231W	DO227903	BRCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1944
p.H239Y	DO225337	BRCA	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.6118
p.A248S	DO229019	LICA	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1389
p.A248S	DO229032	LICA	ICGC	LDLHRD	LIG_APCC_ABBA_1	0.1389
p.E241K	CAL-33	upper_aerodigestive_tract	COSMIC	LDLHRD	LIG_APCC_ABBA_1	0.7022
p.E230Q	HCC1599	breast	COSMIC	LDLHRD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	LIG_APCC_ABBA_1	236:241	LDLHRD	APC,CDC20,FZR1	0.5486	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDLHRD

Degron related mutations and impact score

Drug responses associated with ACACB mutations

All proteins holding degron of LDLHRD