DegronMD

Uniprot ID: O00763

Source protein: Acetyl-CoA carboxylase 2

Source gene: ACACB

Class: DEG_APCC_DBOX_1

Location: 192:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9921

ASA_SCORE: 68.4111

COIL: 0.6787

CONS_SCORE: 0.2565

DSS_SCORE: 0.4283

HELIX: 0.2616

FCONS_SCORE: 1.0413

RIG_SCORE: 0.6838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R185C	TCGA-D5-6529	COAD	TCGA	SRASLGALS	DEG_APCC_DBOX_1	0.1389
p.R185C	DO10758	COAD	ICGC	SRASLGALS	DEG_APCC_DBOX_1	0.1389
p.R185C	DO233865	GACA	ICGC	SRASLGALS	DEG_APCC_DBOX_1	0.1389
p.R185C	SIDM01706	Hodgkin's Lymphoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.1389
p.R185C	ACH-001093	Non-Cancerous	CCLE	SRASLGALS	DEG_APCC_DBOX_1	0.1389
p.A198V	TCGA-FI-A2D5	UCEC	TCGA	SRASLGALS	DEG_APCC_DBOX_1	0.5825
p.A198V	DO41331	UCEC	ICGC	SRASLGALS	DEG_APCC_DBOX_1	0.5825
p.R193L	DO32817	PACA	ICGC	SRASLGALS	DEG_APCC_DBOX_1	0.8428
p.R193L	SIDM01135	Pancreatic Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.8428
p.R193L	ACH-000060	Pancreatic Cancer	CCLE	SRASLGALS	DEG_APCC_DBOX_1	0.8428
p.R193L	PANC-10-05	pancreas	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	0.8428
p.R193W	SIDM02041	Colorectal Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.8634
p.R189Q	SIDM00831	Head and Neck Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.25
p.R189Q	SIDM00797	Melanoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.25
p.R189Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.25
p.R189Q	SIDM00044	Head and Neck Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.25
p.S200C	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	SRASLGALS	DEG_APCC_DBOX_1	0.7541
p.S200C	ACH-000855	Esophageal Cancer	CCLE	SRASLGALS	DEG_APCC_DBOX_1	0.7541
p.S200C	KYSE-150	oesophagus	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	0.7541
p.G182D	ACH-001369	Ovarian Cancer	CCLE	SRASLGALS	DEG_APCC_DBOX_1	0.0556
p.V199A	8305C	thyroid	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	0.6936
p.T202M	HT-29	large_intestine	COSMIC	SRASLGALS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_APCC_DBOX_1	192:200	SRASLGALS	APC,CDC20,FZR1	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons