DegronMD

Uniprot ID: O00763

Source protein: Acetyl-CoA carboxylase 2

Source gene: ACACB

Class: DEG_APCC_KENBOX_2

Location: 889:893

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9263

ASA_SCORE: 80.12

COIL: 0.7224

CONS_SCORE: 0.4756

DSS_SCORE: 0.4186

HELIX: 0.039

FCONS_SCORE: 0.9436

RIG_SCORE: 0.8246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I879N	TCGA-59-2363	OV	TCGA	EKEND	DEG_APCC_KENBOX_2	0.0556
p.I879N	DO29730	OV	ICGC	EKEND	DEG_APCC_KENBOX_2	0.0556
p.G882C	TCGA-A8-A08J	BRCA	TCGA	EKEND	DEG_APCC_KENBOX_2	0.1389
p.G882C	DO2737	BRCA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1389
p.K890N	TCGA-AP-A1DK	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6918
p.K890N	DO42033	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.6918
p.P894L	TCGA-BC-A10R	LIHC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.3056
p.P894L	DO22962	LIHC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.3056
p.D893Y	TCGA-BS-A0UJ	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6214
p.D893Y	DO42745	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	0.6214
p.T885M	TCGA-IB-7651	PAAD	TCGA	EKEND	DEG_APCC_KENBOX_2	0.2222
p.T885M	DO46657	PAAD	ICGC	EKEND	DEG_APCC_KENBOX_2	0.2222
p.D893A	TCGA-XU-A92V	THYM	TCGA	EKEND	DEG_APCC_KENBOX_2	0.6682
p.D893N	DO224735	COCA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.5821
p.R898K	DO222798	COCA	ICGC	EKEND	DEG_APCC_KENBOX_2	0.1944
p.A902V	SIDM00864	Cervical Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	0.0833
p.A902V	ACH-001341	Cervical Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	0.0833
p.A902V	DoTc2-4510	cervix	COSMIC	EKEND	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_APCC_KENBOX_2	889:893	EKEND	APC,CDC20,FZR1	0.9263	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_APCC_KENBOX_2	758:762	EKEND	APC,CDC20,FZR1	0.8227	More...
Q8IUC4	Rhophilin-2	DEG_APCC_KENBOX_2	14:18	EKEND	APC,CDC20,FZR1	0.8735	More...
Q9UGU0	Transcription factor 20	DEG_APCC_KENBOX_2	1513:1517	EKEND	APC,CDC20,FZR1	0.7113	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons