DegronMD - Q8IUC4(RHPN2)

FUNCTION: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.

GO - Biological processes (BP): glomerular filtration [GO:0003094]; negative regulation of stress fiber assembly [GO:0051497]; signal transduction [GO:0007165]

GO - Molecular function (MF):

GO - Cellular component (CC): cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
EKEND	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	Rhophilin-2	14:18	More..
LTPLAT	DEG_SCF_FBW7_1	FBXW7	Rhophilin-2	393:398	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P395H	TCGA-EE-A2GN	SKCM	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.7694
p.P395H	DO37896	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.7694
p.L393M	TCGA-DA-A1IB	SKCM	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.5999
p.L393M	DO38033	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.5999
p.G19D	ACH-001518	Endometrial/Uterine Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.3056
p.P12T	DO229037	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2778
p.P390L	TCGA-B0-5698	KIRC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.P390L	DO20112	KIRC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.F21I	DO229199	THCA	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.25
p.A401T	DO41331	UCEC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.R402L	DO20835	KIRP	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R402L	DO37835	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R402L	DO37703	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R402L	DO37901	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.D402E	DO229229	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.H388Y	DO233737	GACA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1944
p.L5M	DO228978	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation substituting flanking lysine	0.1944
p.R405H	TCGA-FI-A2D0	UCEC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405H	DO43891	UCEC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405C	TCGA-HB-A2OT	SARC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389

Showing 1 to 20 of 57 entries

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No resistance data available for this Degron.

Kaplan plot for RHPN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHPN2

UniProt ID: Q8IUC4

Entrez ID: 85415

Protein name: Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RHPN2 in