DegronMD - Q8IUC4(RHPN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N26T	TCGA-AJ-A3EK	UCEC	TCGA	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1111
p.N26T	DO41584	UCEC	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1111
p.P390L	TCGA-B0-5698	KIRC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.P390L	DO20112	KIRC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.L393M	TCGA-DA-A1IB	SKCM	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.5999
p.L393M	DO38033	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.5999
p.P395H	TCGA-EE-A2GN	SKCM	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.7694
p.P395H	DO37896	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation altering degron motif	0.7694
p.R405H	TCGA-FI-A2D0	UCEC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405H	DO43891	UCEC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405C	TCGA-HB-A2OT	SARC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405C	TCGA-QQ-A8VF	SARC	TCGA	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405C	DO220132	SARC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405C	DO220258	SARC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R406Q	DO227947	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO228260	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO228350	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO228300	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO228449	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO228430	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO222629	BTCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO222829	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO229005	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO223075	ESCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO231265	LAML	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO231334	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.R406Q	DO229100	UTCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.Q384R	DO222765	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO229003	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO50988	LAML	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO51034	LAML	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO228941	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO228947	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO229031	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO229006	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO230545	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO52354	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.Q384R	DO229173	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0833
p.H388Y	DO233737	GACA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1944
p.R402L	DO20835	KIRP	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R402L	DO37835	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R402L	DO37703	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R402L	DO37901	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.R405S	DO228952	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.R405S	DO229041	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1389
p.L5M	DO228978	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation substituting flanking lysine	0.1944
p.P12T	DO229037	LICA	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2778
p.S383A	DO230950	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.0556
p.V385F	DO231067	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.1111
p.F21I	DO229199	THCA	ICGC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.25
p.D402E	DO229229	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.2222
p.A401T	DO41331	UCEC	ICGC	LTPLAT	DEG_SCF_FBW7_1	393:398	Mutation rewiring degron network	0.25
p.C25F	SIDM00035	Thyroid Gland Carcinoma	GDSC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1389
p.C25F	ACH-000037	Sarcoma	CCLE	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1389
p.C25F	S-117	soft tissue	COSMIC	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1389
p.G19D	ACH-001518	Endometrial/Uterine Cancer	CCLE	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.3056
p.A4V	ACH-001735	Leukemia	CCLE	EKEND	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RHPN2

UniProt ID: Q8IUC4

Entrez ID: 85415

Protein name: Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RHPN2 in