DegronMD

Uniprot ID: Q8IUC4

Source protein: Rhophilin-2

Source gene: RHPN2

Class: DEG_SCF_FBW7_1

Location: 393:398

E3 ligase: FBXW7

DEGRON score: 0.5682

ASA_SCORE: 51.2667

COIL: 0.5295

CONS_SCORE: 0.4133

DSS_SCORE: 0.563

HELIX: 0.4173

FCONS_SCORE: 0.8325

RIG_SCORE: 0.751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P390L	TCGA-B0-5698	KIRC	TCGA	LTPLAT	DEG_SCF_FBW7_1	0.25
p.P390L	DO20112	KIRC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.25
p.L393M	TCGA-DA-A1IB	SKCM	TCGA	LTPLAT	DEG_SCF_FBW7_1	0.5999
p.L393M	DO38033	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.5999
p.P395H	TCGA-EE-A2GN	SKCM	TCGA	LTPLAT	DEG_SCF_FBW7_1	0.7694
p.P395H	DO37896	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.7694
p.R405H	TCGA-FI-A2D0	UCEC	TCGA	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R405H	DO43891	UCEC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R405C	TCGA-HB-A2OT	SARC	TCGA	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R405C	TCGA-QQ-A8VF	SARC	TCGA	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R405C	DO220132	SARC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R405C	DO220258	SARC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R406Q	DO227947	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO228260	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO228350	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO228300	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO228449	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO228430	BRCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO222629	BTCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO222829	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO229005	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO223075	ESCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO231265	LAML	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO231334	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.R406Q	DO229100	UTCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.Q384R	DO222765	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO229003	COCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO50988	LAML	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO51034	LAML	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO228941	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO228947	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO229031	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO229006	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO230545	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO52354	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q384R	DO229173	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0833
p.H388Y	DO233737	GACA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1944
p.R402L	DO20835	KIRP	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.2222
p.R402L	DO37835	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.2222
p.R402L	DO37703	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.2222
p.R402L	DO37901	SKCM	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.2222
p.R405S	DO228952	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.R405S	DO229041	LICA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1389
p.S383A	DO230950	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.0556
p.V385F	DO231067	LUSC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.1111
p.D402E	DO229229	THCA	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.2222
p.A401T	DO41331	UCEC	ICGC	LTPLAT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLAT

Degron related mutations and impact score

Drug responses associated with RHPN2 mutations

All proteins holding degron of LTPLAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUC4	Rhophilin-2	DEG_SCF_FBW7_1	393:398	LTPLAT	FBXW7	0.5682	More...