DegronMD

Uniprot ID: O00763

Source protein: Acetyl-CoA carboxylase 2

Source gene: ACACB

Class: LIG_APCC_ABBAyCdc20_2

Location: 235:241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7964

ASA_SCORE: 98.6571

COIL: 0.6701

CONS_SCORE: 0.2722

DSS_SCORE: 0.3525

HELIX: 0.2974

FCONS_SCORE: 0.8685

RIG_SCORE: 0.7833

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K235N	TCGA-37-4130	LUSC	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K235N	DO228952	LICA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K235N	DO26490	LUSC	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.6918
p.H239N	TCGA-43-8115	LUSC	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.7423
p.H239N	DO26440	LUSC	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.7423
p.D241Y	TCGA-AA-3984	COAD	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D241Y	DO9002	COAD	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.7325
p.R231Q	TCGA-AA-A01R	COAD	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R231Q	DO7934	COAD	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R231Q	SIDM00498	Colorectal Carcinoma	GDSC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R231Q	ACH-000970	Colon/Colorectal Cancer	CCLE	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R231Q	SNU-C5	large_intestine	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T243A	TCGA-AJ-A3EL	UCEC	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T243A	DO41542	UCEC	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E249K	TCGA-FD-A6TC	BLCA	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E249K	TCGA-IB-7651	PAAD	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E249K	DO49755	BLCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E249K	DO46657	PAAD	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T243N	TCGA-FG-A87Q	LGG	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T243N	DO51830	LGG	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A248T	TCGA-L5-A4OF	ESCA	TCGA	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A248T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A248T	ACH-000995	Leukemia	CCLE	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A248T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R231W	DO225120	BRCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R231W	DO227903	BRCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H239Y	DO225337	BRCA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.6118
p.A248S	DO229019	LICA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A248S	DO229032	LICA	ICGC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E241K	CAL-33	upper_aerodigestive_tract	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.7022
p.E230Q	HCC1599	breast	COSMIC	KLDLHRD	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KLDLHRD

Degron related mutations and impact score

Drug responses associated with ACACB mutations

All proteins holding degron of KLDLHRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	LIG_APCC_ABBAyCdc20_2	235:241	KLDLHRD	APC,CDC20,FZR1	0.7964	More...