DegronMD - P14316(IRF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W305L	TCGA-44-2655	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1389
p.W305L	DO23557	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1389
p.R331W	TCGA-AJ-A3EK	UCEC	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0833
p.R331W	TCGA-AJ-A3EK	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.R331W	TCGA-CM-6162	COAD	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0833
p.R331W	TCGA-CM-6162	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.R331W	TCGA-DD-AAVS	LIHC	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0833
p.R331W	TCGA-DD-AAVS	LIHC	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.R331W	DO8479	COAD	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0833
p.R331W	DO8479	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.R331W	DO52279	LIHC	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0833
p.R331W	DO52279	LIHC	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.R331W	DO41584	UCEC	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0833
p.R331W	DO41584	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1111
p.R328W	TCGA-B5-A1MX	UCEC	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1667
p.R328W	TCGA-B5-A1MX	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1944
p.R328W	DO41999	UCEC	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1667
p.R328W	DO41999	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1944
p.T330I	TCGA-BH-A18G	BRCA	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1111
p.T330I	TCGA-BH-A18G	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.T330I	DO3686	BRCA	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1111
p.T330I	DO3686	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.S314A	TCGA-ER-A2NG	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7588
p.S314A	DO47552	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7588
p.P312L	TCGA-FW-A3R5	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7582
p.P312L	DO37406	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7582
p.P307L	TCGA-GN-A8LK	SKCM	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0556
p.P307L	TCGA-GN-A8LK	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1944
p.P307L	DO51259	SKCM	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0556
p.P307L	DO51259	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1944
p.D327N	TCGA-TN-A7HL	HNSC	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1944
p.D327N	TCGA-TN-A7HL	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2222
p.D327N	DO219080	HNSC	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1944
p.D327N	DO219080	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2222
p.Q309E	TCGA-UY-A9PB	BLCA	TCGA	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1111
p.Q309E	TCGA-UY-A9PB	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.Q309E	TCGA-UY-A9PB	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0556
p.Q309E	DO219041	BLCA	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1111
p.Q309E	DO219041	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.25
p.Q309E	DO219041	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0556
p.D310N	DO225226	BRCA	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1389
p.D310N	DO225226	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.D310N	DO225226	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.A332G	DO227987	COCA	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.0556
p.A332G	DO227987	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.P306T	DO228985	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.1667
p.S321Y	DO229015	LICA	ICGC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation altering degron motif	0.6009
p.S321Y	DO229015	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.712
p.L313F	DO222868	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.587
p.S316F	SIDM00741	Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7982
p.S316F	NCI-H1694	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.7982
p.R325Q	SIDM00562	Breast Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.25
p.R325Q	SIDM00562	Breast Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.R325Q	SIDM00562	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.R325Q	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.25
p.R325Q	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.R325Q	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.R325Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.25
p.R325Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.R325Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.R325Q	MRK-nu-1	breast	COSMIC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.25
p.R325Q	MRK-nu-1	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.R325Q	MRK-nu-1	breast	COSMIC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.R325Q	TE-8	oesophagus	COSMIC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.25
p.R325Q	TE-8	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.R325Q	TE-8	oesophagus	COSMIC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.R325Q	SW1573	lung	COSMIC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.25
p.R325Q	SW1573	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.0833
p.R325Q	SW1573	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.L313V	SIDM00863	Burkitt's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.5654
p.L313V	ACH-000877	Lymphoma	CCLE	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.5654
p.L313V	ACH-001064	Lymphoma	CCLE	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.5654
p.L313V	EB2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation altering degron motif	0.5654
p.D310G	SIDM01608	Endometrial Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1389
p.D310G	SIDM01608	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.D310G	SIDM01608	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.D310G	ACH-000990	Endometrial/Uterine Cancer	CCLE	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation rewiring degron network	0.1389
p.D310G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	312:316	Mutation rewiring degron network	0.2778
p.D310G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.0833
p.T318A	ACH-000997	Colon/Colorectal Cancer	CCLE	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation altering degron motif	0.7139
p.T318A	ACH-001061	Colon/Colorectal Cancer	CCLE	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation altering degron motif	0.7139
p.T318A	HCT-15	large intestine	COSMIC	MTPASS	DEG_SCF_FBW7_1	317:322	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRF2

UniProt ID: P14316

Entrez ID: 3660

Protein name: Interferon regulatory factor 2 (IRF-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRF2 in