DegronMD

Uniprot ID: P14316

Source protein: Interferon regulatory factor 2

Source gene: IRF2

Class: DEG_SCF_FBW7_1

Location: 317:322

E3 ligase: FBXW7

DEGRON score: 0.9938

ASA_SCORE: 79.9667

COIL: 0.9278

CONS_SCORE: 0.2354

DSS_SCORE: 0.6625

HELIX: 0.0237

FCONS_SCORE: 0.7477

RIG_SCORE: 0.5671

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R331W	TCGA-AJ-A3EK	UCEC	TCGA	MTPASS	DEG_SCF_FBW7_1	0.0833
p.R331W	TCGA-CM-6162	COAD	TCGA	MTPASS	DEG_SCF_FBW7_1	0.0833
p.R331W	TCGA-DD-AAVS	LIHC	TCGA	MTPASS	DEG_SCF_FBW7_1	0.0833
p.R331W	DO8479	COAD	ICGC	MTPASS	DEG_SCF_FBW7_1	0.0833
p.R331W	DO52279	LIHC	ICGC	MTPASS	DEG_SCF_FBW7_1	0.0833
p.R331W	DO41584	UCEC	ICGC	MTPASS	DEG_SCF_FBW7_1	0.0833
p.R328W	TCGA-B5-A1MX	UCEC	TCGA	MTPASS	DEG_SCF_FBW7_1	0.1667
p.R328W	DO41999	UCEC	ICGC	MTPASS	DEG_SCF_FBW7_1	0.1667
p.T330I	TCGA-BH-A18G	BRCA	TCGA	MTPASS	DEG_SCF_FBW7_1	0.1111
p.T330I	DO3686	BRCA	ICGC	MTPASS	DEG_SCF_FBW7_1	0.1111
p.P307L	TCGA-GN-A8LK	SKCM	TCGA	MTPASS	DEG_SCF_FBW7_1	0.0556
p.P307L	DO51259	SKCM	ICGC	MTPASS	DEG_SCF_FBW7_1	0.0556
p.D327N	TCGA-TN-A7HL	HNSC	TCGA	MTPASS	DEG_SCF_FBW7_1	0.1944
p.D327N	DO219080	HNSC	ICGC	MTPASS	DEG_SCF_FBW7_1	0.1944
p.Q309E	TCGA-UY-A9PB	BLCA	TCGA	MTPASS	DEG_SCF_FBW7_1	0.1111
p.Q309E	DO219041	BLCA	ICGC	MTPASS	DEG_SCF_FBW7_1	0.1111
p.D310N	DO225226	BRCA	ICGC	MTPASS	DEG_SCF_FBW7_1	0.1389
p.A332G	DO227987	COCA	ICGC	MTPASS	DEG_SCF_FBW7_1	0.0556
p.S321Y	DO229015	LICA	ICGC	MTPASS	DEG_SCF_FBW7_1	0.6009
p.R325Q	SIDM00562	Breast Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	0.25
p.R325Q	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	0.25
p.R325Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	0.25
p.R325Q	MRK-nu-1	breast	COSMIC	MTPASS	DEG_SCF_FBW7_1	0.25
p.R325Q	TE-8	oesophagus	COSMIC	MTPASS	DEG_SCF_FBW7_1	0.25
p.R325Q	SW1573	lung	COSMIC	MTPASS	DEG_SCF_FBW7_1	0.25
p.D310G	SIDM01608	Endometrial Carcinoma	GDSC	MTPASS	DEG_SCF_FBW7_1	0.1389
p.D310G	ACH-000990	Endometrial/Uterine Cancer	CCLE	MTPASS	DEG_SCF_FBW7_1	0.1389
p.T318A	ACH-000997	Colon/Colorectal Cancer	CCLE	MTPASS	DEG_SCF_FBW7_1	0.7139
p.T318A	ACH-001061	Colon/Colorectal Cancer	CCLE	MTPASS	DEG_SCF_FBW7_1	0.7139
p.T318A	HCT-15	large_intestine	COSMIC	MTPASS	DEG_SCF_FBW7_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPASS

Degron related mutations and impact score

Drug responses associated with IRF2 mutations

All proteins holding degron of MTPASS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14316	Interferon regulatory factor 2	DEG_SCF_FBW7_1	317:322	MTPASS	FBXW7	0.9938	More...