DegronMD

Uniprot ID: P04637

Source protein: Cellular tumor antigen p53

Source gene: TP53

Class: DEG_SPOP_SBC_1

Location: 92:96

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 69.06

COIL: 0.8926

CONS_SCORE: 0.4186

DSS_SCORE: 0.4748

HELIX: 0.0602

FCONS_SCORE: 1.0313

RIG_SCORE: 0.6458

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G105D	TCGA-05-4398	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105D	TCGA-95-8039	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105D	DO25847	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105D	DO51197	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	TCGA-13-1494	OV	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	TCGA-34-2604	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	TCGA-49-AAR4	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	TCGA-77-6843	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	TCGA-CV-7413	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	TCGA-DK-AA6U	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO219008	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO15567	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO218920	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO26433	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO27588	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO32698	OV	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	DO224705	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105C	SIDM01280	Esophageal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105R	TCGA-14-1034	GBM	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105R	TCGA-20-0987	OV	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105R	DO11148	GBM	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105R	DO31210	OV	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105R	ACH-000419	Myeloma	CCLE	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105R	ACH-001541	Myeloma	CCLE	PLSSS	DEG_SPOP_SBC_1	0.0833
p.Q104H	TCGA-17-Z031	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.1111
p.G105S	TCGA-56-7730	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105S	DO229263	LMS	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105S	DO26617	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	TCGA-63-A5MW	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	TCGA-77-8139	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	TCGA-BA-A6DL	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	TCGA-CN-A6V3	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO233184	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO52050	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO52035	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO228192	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO26524	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO219169	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G105V	DO229068	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.S106R	TCGA-98-A53I	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	TCGA-CR-7390	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	TCGA-DD-AADV	LIHC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	TCGA-UF-A7JO	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	TCGA-XP-A8T8	ESCA	TCGA	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	DO219088	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	DO14302	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	DO219573	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	DO23462	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	DO219182	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	DO49183	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	SIDM00375	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	ACH-002305	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	0.5
p.S106R	SKN-3	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.Q100K	TCGA-BQ-7049	KIRP	TCGA	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Q100K	DO20853	KIRP	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Q100K	DO232049	ORCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.P92S	TCGA-DF-A2KU	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	0.6752
p.P92S	DO223286	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	0.6752
p.V97D	TCGA-VQ-A8PP	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.3056
p.V97D	DO51774	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.P82L	TCGA-XK-AAIW	PRAD	TCGA	PLSSS	DEG_SPOP_SBC_1	0.0556
p.P82L	DO51407	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.P92T	DO228952	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.7031
p.A88D	DO228974	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.P92H	DO229045	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.7694
p.P87Q	DO232036	ORCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.G105A	DO232131	RECA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.P98L	SIDM00684	Glioblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.P98L	ACH-000595	Brain Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	0.2778
p.P98L	LN-229	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.S90F	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.S95F	SIDM01617	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.7982
p.S95F	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	0.7982
p.P98S	ACH-001421	Eye Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	0.2778
p.N88K	IST-MEL1	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.K93R	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7237
p.K93R	DIFI	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7237
p.K93R	MFM-223	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7237
p.R89L	SBC-5	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89L	NCI-H1573	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89L	NCI-H322M	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89L	FADU	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.I100S	H2731	pleura	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.V84M	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.V84M	ECC12	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.V84M	OV-17R	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.E92D	RERF-LC-KJ	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6758
p.E92D	NCI-H716	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6758
p.Y88C	HCC-366	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	HCC1419	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	RH-1	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	MFE-296	endometrium	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	MFE-319	endometrium	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	NCI-H748	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	NCI-H2342	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	BxPC-3	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	KON	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	HuH-7	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	NUGC-3	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	451Lu	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	NCI-H2085	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88C	MDA-MB-330	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.G86S	SU8686	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	D-423MG	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	no-10	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	D-566MG	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	KINGS-1	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	HSC-39	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	LS-1034	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	SK-NEP-1	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	SK-LMS-1	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	D-542MG	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	SK-MEL-2	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86S	PANC-04-03	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G85D	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.G85D	PEO1	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.G103S	NB7	autonomic_ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.S82F	KALS-1	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82F	MCC13	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82F	HCC-78	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82F	HCT-15	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82F	DMS-53	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82F	ES-2	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.G86V	HCE-4	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86V	CPC-N	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86V	HT-3	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.R89Q	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	639-V	urinary_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	KYSE-150	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	NCI-N87	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	PC-14	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	WM1552C	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	HEC-1	endometrium	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	ES5	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	RT-112	urinary_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	PANC-02-03	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	OACM5-1	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	SF295	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	HCC1143	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	HCC70	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	NCI-H211	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	Hs683	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	KINGS-1	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	SK-UT-1	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	SW1463	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	CL-40	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	ES1	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	OVCAR-3	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	TE-6	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89Q	HSC-4	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.C106S	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.C106S	LN-18	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.C106Y	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.V104A	MKN1	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.V104A	HARA	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.M105I	Calu-3	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.M105I	NCI-H1869	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.M105I	LC-1-sq	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.M105I	T98G	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.M105I	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.M105I	TE-8	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.Y104C	NCI-H345	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.Y104C	MDA-MB-415	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.Y104C	GMS-10	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.Y104C	NCI-H2444	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.Y104C	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.C83Y	HCC-33	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.C83Y	TE-10	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.E99K	Mewo	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6944
p.E99K	SNB75	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6944
p.R89W	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	HCC2157	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	MIA-PaCa-2	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	LXF-289	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	GCT	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	D-336MG	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	COLO-680N	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	SW837	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	RCC-ER	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	COLO-320-HSR	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	BB65-RCC	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	JIMT-1	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	ESO26	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	KYSE-220	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	RD	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	VCaP	prostate	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	Ca9-22	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	SNU-1040	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	NCI-H1770	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	IST-MEL1	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	SNU-C5	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	CAS-1	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.R89W	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.G85S	MS-1	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.G85S	OCUB-M	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.K93Q	PSN1	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6944
p.K93Q	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6944
p.K93Q	BT-20	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6944
p.I96N	PANC-10-05	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.728
p.P91L	RO82-W-1	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.P91L	HT-1376	urinary_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.P91L	DU-145	prostate	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.K93T	SNU-81	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7306
p.M87R	SK-N-FI	autonomic_ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.I95N	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.728
p.V84L	LCLC-103H	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.V84L	Hs940-T	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.L91F	Sarc9371	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.R90S	NCI-H1105	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.R90S	JHH-4	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.R90S	BT-549	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.R90S	OSC-20	upper_aerodigestive_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.R90S	KNS-62	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.I92T	BHT-101	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7078
p.V104M	LOU-NH91	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.V104M	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1111
p.F95L	Sarc9371	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6981
p.S83R	OV-90	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.I96S	CGTH-W-1	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7341
p.Y88D	NCI-H2029	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.Y88D	FU97	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.I92L	MKN28	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7174
p.M94K	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.8062
p.M94K	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.8062
p.K93N	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6918
p.K93N	SKG-IIIa	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6918
p.K93N	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6918
p.Y87D	A704	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.C83F	NCI-H1755	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.C83F	SKN	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.C83F	Daoy	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.S82A	201T	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.Y102C	NCI-H1304	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.Y102C	EC-GI-10	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.Y102C	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.C102W	NCI-H1435	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.S82C	NCI-H187	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82C	LC-2-ad	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82C	EVSA-T	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.S82C	BFTC-909	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.E92K	CAL-148	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7022
p.C96R	A704	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.8301
p.C96R	COLO-800	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.8301
p.S82Y	LB831-BLC	urinary_tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.K93E	CAL-85-1	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7022
p.G86C	COLO-668	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86C	NCI-H596	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86C	DMS-273	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86C	TE-4	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.C96F	A388	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7108
p.C96F	CAL-12T	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7108
p.C96F	ES8	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7108
p.C96F	BE2-M17	autonomic_ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7108
p.C96F	KP-N-YS	autonomic_ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7108
p.G85A	HLE	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.G103D	SNU-475	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.D100V	HCC-15	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.M105K	SK-LMS-1	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.I95S	OV-7	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7341
p.L106R	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.L106R	SK-MEL-28	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.C85R	EFO-21	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.Y102N	SU-DHL-8	NS	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.M87I	BT-483	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.M87I	NCI-H23	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.S83I	NCI-H661	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.S83I	SNU-182	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.L105R	TK10	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.A99P	RL	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.6944
p.V86L	SNU-C5	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.D100Y	BCPAP	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.D100Y	COR-L95	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.C96Y	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7087
p.C96Y	OE33	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7087
p.S83C	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.I95V	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7076
p.I100N	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.S102T	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.L91V	OVCAR-4	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.L91V	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.3056
p.G85C	LU-135	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.G85C	NCI-H1836	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.T86M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.I92N	SW872	soft_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.728
p.R89P	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.M87T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.R90G	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.R90G	SU-DHL-8	NS	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.C83R	CFPAC-1	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.H82R	NCI-H1963	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.H82R	T-T	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.I96T	HuP-T4	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7078
p.Y87C	IGROV-1	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1944
p.G86D	CS1	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.G86D	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667
p.S83N	CL-11	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.C106F	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.R89G	8505C	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.25
p.C83S	NCI-H841	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.G103V	SW626	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.G103V	NCI-H2030	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1389
p.S88P	CL-34	large_intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.L106P	GAMG	central_nervous_system	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.5
p.C83W	NCI-H1993	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.0833
p.Y102H	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.1667

Drug responses associated with TP53 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.V157F (No)	GDSC	MIRA-1	565
SIDM01139	PAAD\|pancreas	p.R248Q (No)	GDSC	MIRA-1	690.98
SIDM00290	STAD\|stomach	p.P153fs*28 (No)	GDSC	MIRA-1	126.26
SIDM00554	UNCLASSIFIED\|ovary	p.D281Y (No)	GDSC	MIRA-1	1072.2
SIDM01194	LIHC\|liver	p.A161T (No)	GDSC	MIRA-1	365.9
SIDM00130	PAAD\|pancreas	p.C242R (No)	GDSC	MIRA-1	601.28
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R248Q (No)	GDSC	MIRA-1	34.36
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.M237I (No)	GDSC	MIRA-1	128.49
SIDM00918	OV\|ovary	p.V147D (No)	GDSC	MIRA-1	535.57
SIDM00402	BLCA\|bladder	p.R248Q (No)	GDSC	MIRA-1	181.31
SIDM00402	BLCA\|bladder	p.S183* (No)	GDSC	MIRA-1	181.31
SIDM00533	PAAD\|pancreas	p.R282W (No)	GDSC	MIRA-1	649.85
SIDM00592	HNSC\|head_and_neck	p.G266R (No)	GDSC	MIRA-1	139.56
SIDM01228	SKCM\|melanoma	p.H193R (No)	GDSC	MIRA-1	180.66
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.Q331* (No)	GDSC	MIRA-1	881.68
SIDM01164	LGG\|glioma	p.R273H (No)	GDSC	MIRA-1	126.81
SIDM01164	LGG\|glioma	p.R273C (No)	GDSC	MIRA-1	126.81
SIDM00935	CESC\|cervix	p.P151H (No)	GDSC	MIRA-1	143.18
SIDM01180	LIHC\|liver	p.K164* (No)	GDSC	MIRA-1	417.85
SIDM00841	COREAD\|large_intestine	p.R273H (No)	GDSC	MIRA-1	2337
SIDM00931	THCA\|thyroid	p.A161D (No)	GDSC	MIRA-1	150.57
SIDM00776	COREAD\|large_intestine	p.R175H (No)	GDSC	MIRA-1	835.49
SIDM01024	ESCA\|oesophagus	p.K120N (No)	GDSC	MIRA-1	809.31
SIDM01031	ESCA\|oesophagus	p.R248Q (No)	GDSC	MIRA-1	179.87
SIDM01188	PAAD\|pancreas	p.G245S (No)	GDSC	MIRA-1	2173.3
SIDM00678	BLCA\|bladder	p.P250L (No)	GDSC	MIRA-1	627.06
SIDM00420	BLCA\|bladder	p.R273C (No)	GDSC	MIRA-1	307.89
SIDM00778	COREAD\|large_intestine	p.R158L (No)	GDSC	MIRA-1	854.41
SIDM01037	BRCA\|breast	p.R248W (No)	GDSC	MIRA-1	265.19
SIDM00358	STAD\|stomach	p.R213* (No)	GDSC	MIRA-1	282.84
SIDM00970	BLCA\|bladder	p.R158H (No)	GDSC	MIRA-1	168.99
SIDM00572	STAD\|stomach	p.Y220C (No)	GDSC	MIRA-1	386.87
SIDM00614	LIHC\|liver	p.R267P (No)	GDSC	MIRA-1	481.47
SIDM00588	HNSC\|head_and_neck	p.R248Q (No)	GDSC	MIRA-1	222.86
SIDM00213	THCA\|thyroid	p.R273H (No)	GDSC	MIRA-1	444.1
SIDM00271	UNCLASSIFIED\|stomach	p.V143A (No)	GDSC	MIRA-1	472.87
SIDM00087	MM\|myeloma	p.E285K (No)	GDSC	MIRA-1	94.354
SIDM00874	BRCA\|breast	p.R306* (No)	GDSC	MIRA-1	661.7
SIDM01135	PAAD\|pancreas	p.I255N (No)	GDSC	MIRA-1	826.14
SIDM00083	LGG\|glioma	p.R342fs*3 (No)	GDSC	MIRA-1	118.48
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R248L (No)	GDSC	MIRA-1	504.01
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R273H (No)	GDSC	MIRA-1	59.401
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.W91* (Yes)	GDSC	MIRA-1	59.401
SIDM00538	ESCA\|oesophagus	p.R175H (No)	GDSC	MIRA-1	477.76
SIDM00151	OV\|ovary	p.Y126C (No)	GDSC	MIRA-1	254.87
SIDM00499	PRAD\|prostate	p.Q331R (No)	GDSC	MIRA-1	438.14
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.R248P (No)	GDSC	MIRA-1	2.225
SIDM00145	ALL\|lymphoblastic_leukemia	p.R337* (No)	GDSC	MIRA-1	107.19
SIDM00145	ALL\|lymphoblastic_leukemia	p.R306* (No)	GDSC	MIRA-1	107.19
SIDM00967	OV\|ovary	p.R273H (No)	GDSC	MIRA-1	577.48
SIDM01032	ESCA\|oesophagus	p.H193R (No)	GDSC	MIRA-1	213
SIDM00455	PAAD\|pancreas	p.C176S (No)	GDSC	MIRA-1	966.22
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.R273H (No)	GDSC	MIRA-1	3401.2
SIDM00121	ALL\|lymphoblastic_leukemia	p.R248Q (No)	GDSC	MIRA-1	62.852
SIDM00121	ALL\|lymphoblastic_leukemia	p.R175H (No)	GDSC	MIRA-1	62.852
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.L35fs*9 (No)	GDSC	MIRA-1	110.42
SIDM00550	ESCA\|oesophagus	p.K101* (Yes)	GDSC	MIRA-1	244.08
SIDM00997	THCA\|thyroid	p.R273C (No)	GDSC	MIRA-1	282.2
SIDM00901	UCEC\|endometrium	p.R213Q (No)	GDSC	MIRA-1	65.639
SIDM00351	HNSC\|head_and_neck	p.E336* (No)	GDSC	MIRA-1	60.58
SIDM00849	KIRC\|kidney	p.E258* (No)	GDSC	MIRA-1	229.01
SIDM00849	KIRC\|kidney	p.C135R (No)	GDSC	MIRA-1	229.01
SIDM00849	KIRC\|kidney	p.Y126D (No)	GDSC	MIRA-1	229.01
SIDM00334	UCEC\|endometrium	p.R306* (No)	GDSC	MIRA-1	484.4
SIDM00334	UCEC\|endometrium	p.Y220C (No)	GDSC	MIRA-1	484.4
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.P47fs*76 (No)	GDSC	MIRA-1	227.46
SIDM00260	STAD\|stomach	p.I251L (No)	GDSC	MIRA-1	451.45
SIDM00831	HNSC\|head_and_neck	p.R175H (No)	GDSC	MIRA-1	167.88
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.G245V (No)	GDSC	MIRA-1	22.559
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.P191fs*56 (No)	GDSC	MIRA-1	269.96
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.R273H (No)	GDSC	MIRA-1	166.64
SIDM00937	HNSC\|head_and_neck	p.H193L (No)	GDSC	MIRA-1	231.66
SIDM00353	UNCLASSIFIED\|ovary	p.R175H (No)	GDSC	MIRA-1	696.06
SIDM00196	UNCLASSIFIED\|ewings_sarcoma	p.R175H (No)	GDSC	MIRA-1	152.18
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.M246I (No)	GDSC	MIRA-1	220.58
SIDM00252	UNCLASSIFIED\|biliary_tract	p.C176fs*6 (No)	GDSC	MIRA-1	354.16
SIDM00797	SKCM\|melanoma	p.V274F (No)	GDSC	MIRA-1	103.26
SIDM00453	PAAD\|pancreas	p.R282W (No)	GDSC	MIRA-1	437.54
SIDM00214	COREAD\|large_intestine	p.S90fs*33 (Yes)	GDSC	MIRA-1	289.9
SIDM00976	SKCM\|melanoma	p.R248Q (No)	GDSC	MIRA-1	155.6
SIDM00956	ESCA\|oesophagus	p.R248W (No)	GDSC	MIRA-1	909.12
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.R248Q (No)	GDSC	MIRA-1	3.0672
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.R248Q (No)	GDSC	MIRA-1	59.71
SIDM00350	HNSC\|head_and_neck	p.E271* (No)	GDSC	MIRA-1	390.63
SIDM00350	HNSC\|head_and_neck	p.R110L (No)	GDSC	MIRA-1	390.63
SIDM00045	STAD\|stomach	p.G245S (No)	GDSC	MIRA-1	56.032
SIDM01048	MM\|lymphoid_neoplasm_other	p.K132N (No)	GDSC	MIRA-1	105.3
SIDM00250	ESCA\|oesophagus	p.G245C (No)	GDSC	MIRA-1	163.51
SIDM00267	UNCLASSIFIED\|biliary_tract	p.C242fs*5 (No)	GDSC	MIRA-1	486.44
SIDM00199	UNCLASSIFIED\|bone_other	p.G245D (No)	GDSC	MIRA-1	199.8
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.C176W (No)	GDSC	MIRA-1	89.12
SIDM00669	PAAD\|pancreas	p.P151S (No)	GDSC	MIRA-1	781.36
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R273H (No)	GDSC	MIRA-1	209.76
SIDM01007	ALL\|lymphoblastic_leukemia	p.R273C (No)	GDSC	MIRA-1	82.935
SIDM01007	ALL\|lymphoblastic_leukemia	p.R175H (No)	GDSC	MIRA-1	82.935
SIDM00781	COREAD\|large_intestine	p.R273H (No)	GDSC	MIRA-1	3509.2
SIDM00781	COREAD\|large_intestine	p.R273C (No)	GDSC	MIRA-1	3509.2
SIDM00391	MM\|myeloma	p.K132N (No)	GDSC	MIRA-1	157.96
SIDM00146	BRCA\|breast	p.R280K (No)	GDSC	MIRA-1	121.9
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.K132R (No)	GDSC	MIRA-1	17.497
SIDM00326	ESCA\|oesophagus	p.M237I (No)	GDSC	MIRA-1	217.3
SIDM01229	NB\|neuroblastoma	p.C135F (No)	GDSC	MIRA-1	311.84
SIDM00381	CESC\|cervix	p.R273H (No)	GDSC	MIRA-1	290.38
SIDM00381	CESC\|cervix	p.K132N (No)	GDSC	MIRA-1	290.38
SIDM00088	PRAD\|prostate	p.K139fs*31 (No)	GDSC	MIRA-1	844.28
SIDM01190	BLCA\|bladder	p.E349* (No)	GDSC	MIRA-1	638.61
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V143M (No)	GDSC	MIRA-1	563.51
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.R273H (No)	GDSC	MIRA-1	1699.5
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.R209* (No)	GDSC	MIRA-1	1699.5
SIDM00393	STAD\|stomach	p.R175H (No)	GDSC	MIRA-1	195.89
SIDM01056	BRCA\|breast	p.H193R (No)	GDSC	MIRA-1	187.59
SIDM00565	HNSC\|head_and_neck	p.R249S (No)	GDSC	MIRA-1	543.37
SIDM01009	NB\|neuroblastoma	p.P177T (No)	GDSC	MIRA-1	91.967
SIDM00100	MESO\|mesothelioma	p.R273C (No)	GDSC	MIRA-1	879.07
SIDM00936	BLCA\|bladder	p.R282W (No)	GDSC	MIRA-1	275.88
SIDM00686	UCEC\|endometrium	p.R175H (No)	GDSC	MIRA-1	1104
SIDM00466	OV\|ovary	p.R282W (No)	GDSC	MIRA-1	3815
SIDM01132	MB\|medulloblastoma	p.C275G (No)	GDSC	MIRA-1	158.5
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.C135F (No)	GDSC	MIRA-1	101.75
SIDM00212	GBM\|glioma	p.R248W (No)	GDSC	MIRA-1	631.04
SIDM00251	STAD\|stomach	p.R273C (No)	GDSC	MIRA-1	212.8
SIDM00499	PRAD\|prostate	p.V73fs*50 (No)	GDSC	MIRA-1	438.14
SIDM00814	ACC\|adrenal_gland	p.H193Y (No)	GDSC	MIRA-1	107.53
SIDM00085	GBM\|glioma	p.R273H (No)	GDSC	MIRA-1	407.73
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R248Q (No)	GDSC	MIRA-1	41.671
SIDM00732	GBM\|glioma	p.R175H (No)	GDSC	MIRA-1	108.31
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.R175H (No)	GDSC	MIRA-1	155.59
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.Y234H (No)	GDSC	MIRA-1	54.855
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.R213Q (No)	GDSC	MIRA-1	54.855
SIDM00220	OV\|ovary	p.R273H (No)	GDSC	MIRA-1	177.8
SIDM01030	ESCA\|oesophagus	p.I195T (No)	GDSC	MIRA-1	209.03
SIDM00938	BRCA\|breast	p.E224K (No)	GDSC	MIRA-1	65.804
SIDM00655	\|testis	p.V272fs*73 (No)	GDSC	MIRA-1	71.548
SIDM01099	NB\|neuroblastoma	p.M246R (No)	GDSC	MIRA-1	174.94
SIDM00003	SKCM\|melanoma	p.G266E (No)	GDSC	MIRA-1	314.33
SIDM00901	UCEC\|endometrium	p.S90fs*33 (Yes)	GDSC	MIRA-1	65.639
SIDM00444	ESCA\|oesophagus	p.T55fs*68 (No)	GDSC	MIRA-1	163.57
SIDM00675	BRCA\|breast	p.R273L (No)	GDSC	MIRA-1	220.46
SIDM00998	GBM\|glioma	p.R273C (No)	GDSC	MIRA-1	144.74
SIDM00377	UNCLASSIFIED\|uterus	p.C242F (No)	GDSC	MIRA-1	322.42
SIDM00887	MB\|medulloblastoma	p.C242F (No)	GDSC	MIRA-1	158.19
SIDM00875	UNCLASSIFIED\|breast	p.T256fs*90 (No)	GDSC	MIRA-1	138.85
SIDM00586	LIHC\|liver	p.R110L (No)	GDSC	MIRA-1	693.08
SIDM00498	COREAD\|large_intestine	p.R248W (No)	GDSC	MIRA-1	396.32
SIDM00551	ESCA\|oesophagus	p.R248W (No)	GDSC	MIRA-1	102.18
SIDM00483	ESCA\|oesophagus	p.Q100* (Yes)	GDSC	MIRA-1	1471.3
SIDM01043	UNCLASSIFIED\|endometrium	p.R213* (No)	GDSC	MIRA-1	129.52
SIDM00629	BRCA\|breast	p.E204fs*7 (No)	GDSC	MIRA-1	435.56
SIDM01168	OV\|ovary	p.G262V (No)	GDSC	MIRA-1	976.06
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.V272L (No)	GDSC	MIRA-1	73.428
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.T155N (No)	GDSC	MIRA-1	78.288
SIDM01197	COREAD\|large_intestine	p.S166* (No)	GDSC	MIRA-1	441.04
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.R248Q (No)	GDSC	MIRA-1	9.33
SIDM00612	LGG\|glioma	p.R248Q (No)	GDSC	MIRA-1	759.24
SIDM00612	LGG\|glioma	p.G245S (No)	GDSC	MIRA-1	759.24
SIDM00151	OV\|ovary	p.S90fs*59 (Yes)	GDSC	MIRA-1	254.87
SIDM00982	GBM\|glioma	p.R282Q (No)	GDSC	MIRA-1	241.93
SIDM00316	GBM\|glioma	p.F113V (No)	GDSC	MIRA-1	188.46
SIDM00553	LAML\|leukemia	p.R175H (No)	GDSC	MIRA-1	8.9244
SIDM00418	THCA\|thyroid	p.R273C (No)	GDSC	MIRA-1	1836.1
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R273L (No)	GDSC	MIRA-1	190.25
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.V157F (No)	GDSC	MIRA-1	833.08
SIDM00988	KIRC\|kidney	p.S241C (No)	GDSC	MIRA-1	191.31
SIDM00988	KIRC\|kidney	p.E224* (No)	GDSC	MIRA-1	191.31
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R158H (No)	GDSC	MIRA-1	7.5992
SIDM00488	COREAD\|large_intestine	p.V272M (No)	GDSC	MIRA-1	184.78
SIDM00194	COREAD\|large_intestine	p.R175H (No)	GDSC	MIRA-1	628.67
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R213Q (No)	GDSC	MIRA-1	6.8249
SIDM00774	BRCA\|breast	p.R248W (No)	GDSC	MIRA-1	48.411
SIDM00504	LGG\|glioma	p.R110P (No)	GDSC	MIRA-1	140.8
SIDM00411	PAAD\|pancreas	p.H179R (No)	GDSC	MIRA-1	659.84
SIDM01077	PRAD\|prostate	p.R248W (No)	GDSC	MIRA-1	308.09
SIDM01020	MM\|myeloma	p.R337L (No)	GDSC	MIRA-1	26.978
SIDM00347	ESCA\|oesophagus	p.V272L (No)	GDSC	MIRA-1	362.04
SIDM00716	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R158G (No)	GDSC	MIRA-1	266.55
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.G154V (No)	GDSC	MIRA-1	208.34
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.Y163C (No)	GDSC	MIRA-1	41.359
SIDM00505	PAAD\|pancreas	p.R248W (No)	GDSC	MIRA-1	147
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.G244C (No)	GDSC	MIRA-1	44.616
SIDM00156	NB\|neuroblastoma	p.P278L (No)	GDSC	MIRA-1	217.36
SIDM00156	NB\|neuroblastoma	p.G262S (No)	GDSC	MIRA-1	217.36
SIDM00251	STAD\|stomach	p.K382fs*40 (No)	GDSC	MIRA-1	212.8
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.Q192* (No)	GDSC	MIRA-1	189.53
SIDM00506	SCLC\|lung_small_cell_carcinoma	p.V157F (No)	GDSC	MIRA-1	45.658
SIDM00833	COREAD\|large_intestine	p.R248W (No)	GDSC	MIRA-1	468.07
SIDM01045	UCEC\|endometrium	p.R273H (No)	GDSC	MIRA-1	217.79
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.R273L (No)	GDSC	MIRA-1	1208.1
SIDM01028	ESCA\|oesophagus	p.R337C (No)	GDSC	MIRA-1	986.94
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.E171* (No)	GDSC	MIRA-1	102.01
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E171* (No)	GDSC	MIRA-1	447.25
SIDM00532	LGG\|glioma	p.A159V (No)	GDSC	MIRA-1	732.31
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S215I (No)	GDSC	MIRA-1	532.45
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R158L (No)	GDSC	MIRA-1	532.45
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.E285V (No)	GDSC	MIRA-1	263.66
SIDM00872	BRCA\|breast	p.Y163C (No)	GDSC	MIRA-1	264.85
SIDM00946	ALL\|T_cell_leukemia	p.R248Q (No)	GDSC	MIRA-1	70.626
SIDM01019	LAML\|acute_myeloid_leukaemia	p.V272M (No)	GDSC	MIRA-1	89.165
SIDM00369	ESCA\|oesophagus	p.V272M (No)	GDSC	MIRA-1	388.65
SIDM00325	ESCA\|oesophagus	p.N268fs*77 (No)	GDSC	MIRA-1	183.92
SIDM00568	STAD\|stomach	p.V31I (No)	GDSC	MIRA-1	353.07
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.Q317* (No)	GDSC	MIRA-1	348.92
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.R248W (No)	GDSC	MIRA-1	348.92
SIDM01165	PAAD\|pancreas	p.P191delP (No)	GDSC	MIRA-1	433.66
SIDM00211	ALL\|lymphoblastic_leukemia	p.R248Q (No)	GDSC	MIRA-1	40.742
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.R248L (No)	GDSC	MIRA-1	485.74
SIDM00882	BRCA\|breast	p.A74fs*47 (No)	GDSC	MIRA-1	200.72
SIDM00042	PAAD\|pancreas	p.G266V (No)	GDSC	MIRA-1	451.93
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.Q136fs*13 (No)	GDSC	MIRA-1	217.41
SIDM00333	UCEC\|endometrium	p.R273C (No)	GDSC	MIRA-1	249.98
SIDM00333	UCEC\|endometrium	p.Y220C (No)	GDSC	MIRA-1	249.98
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V143A (No)	GDSC	MIRA-1	126.02
SIDM01193	GBM\|glioma	p.R213Q (No)	GDSC	MIRA-1	547.42
SIDM00122	BRCA\|breast	p.R249S (No)	GDSC	MIRA-1	511.32
SIDM00530	ESCA\|oesophagus	p.P152L (No)	GDSC	MIRA-1	265.9
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.I232N (No)	GDSC	MIRA-1	6.1184
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.P152L (No)	GDSC	MIRA-1	6.1184
SIDM00667	UNCLASSIFIED\|fibrosarcoma	p.E285fs*60 (No)	GDSC	MIRA-1	127.98
SIDM00630	BRCA\|breast	p.Y236C (No)	GDSC	MIRA-1	69.84
SIDM00489	HNSC\|head_and_neck	p.R248W (No)	GDSC	MIRA-1	185.6
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.R283P (No)	GDSC	MIRA-1	57.604
SIDM00044	HNSC\|head_and_neck	p.P153fs*28 (No)	GDSC	MIRA-1	434.72
SIDM01155	GBM\|glioma	p.R273C (No)	GDSC	MIRA-1	304.2
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.C277F (No)	GDSC	MIRA-1	686.09
SIDM00796	UNCLASSIFIED\|head_and_neck	p.E180fs*67 (No)	GDSC	MIRA-1	168.76
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.S241F (No)	GDSC	MIRA-1	500.17
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.E56* (No)	GDSC	MIRA-1	500.17
SIDM00999	BLCA\|bladder	p.R248Q (No)	GDSC	MIRA-1	198.51
SIDM00079	OV\|ovary	p.S90fs*33 (Yes)	GDSC	MIRA-1	1082.5
SIDM00287	UNCLASSIFIED\|B_cell_leukemia	p.D281G (No)	GDSC	MIRA-1	9.2198
SIDM00893	BRCA\|breast	p.K132Q (No)	GDSC	MIRA-1	147.27
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.L35fs*8 (No)	GDSC	MIRA-1	243
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R175L (No)	GDSC	MIRA-1	641.28
SIDM00807	BLCA\|bladder	p.R280T (No)	GDSC	MIRA-1	385.04
SIDM00478	ESCA\|oesophagus	p.S90fs*33 (Yes)	GDSC	MIRA-1	330.71
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.R175L (No)	GDSC	MIRA-1	234.59
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.S94* (Yes)	GDSC	MIRA-1	234.59
SIDM00094	KIRC\|kidney	p.E336* (No)	GDSC	MIRA-1	436.3
SIDM00681	COREAD\|large_intestine	p.G245S (No)	GDSC	MIRA-1	227.22
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R283H (No)	GDSC	MIRA-1	194.29
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G245S (No)	GDSC	MIRA-1	194.29
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.C176W (No)	GDSC	MIRA-1	243.34
SIDM00323	DLBC\|B_cell_lymphoma	p.E180* (No)	GDSC	MIRA-1	103.51
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R273C (No)	GDSC	MIRA-1	6.1438
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.A76fs*73 (No)	GDSC	MIRA-1	492.2
SIDM00082	SKCM\|melanoma	p.G245S (No)	GDSC	MIRA-1	72.124
SIDM00889	CESC\|cervix	p.R273C (No)	GDSC	MIRA-1	223.45
SIDM00898	BRCA\|breast	p.R175H (No)	GDSC	MIRA-1	213.68
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.R248Q (No)	GDSC	MIRA-1	98.361
SIDM01042	BRCA\|breast	p.S241C (No)	GDSC	MIRA-1	101.12
SIDM00049	COREAD\|large_intestine	p.K132R (No)	GDSC	MIRA-1	288.92
SIDM00665	STAD\|stomach	p.K319* (No)	GDSC	MIRA-1	512.24
SIDM01141	OV\|ovary	p.S215R (No)	GDSC	MIRA-1	529.32
SIDM00276	UNCLASSIFIED\|biliary_tract	p.R175H (No)	GDSC	MIRA-1	316.83
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M237I (No)	GDSC	MIRA-1	173.54
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.I254N (No)	GDSC	MIRA-1	40.566
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.I254V (No)	GDSC	MIRA-1	40.566
SIDM00571	UNCLASSIFIED\|pancreas	p.P153fs*28 (No)	GDSC	MIRA-1	566.24
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.C242W (No)	GDSC	MIRA-1	288.33
SIDM00111	GBM\|glioma	p.R273H (No)	GDSC	MIRA-1	497.64
SIDM00477	ESCA\|oesophagus	p.C135Y (No)	GDSC	MIRA-1	347.66
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.N239D (No)	GDSC	MIRA-1	24.456
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.R158H (No)	GDSC	MIRA-1	24.456
SIDM00596	UCEC\|endometrium	p.R248Q (No)	GDSC	MIRA-1	484.38
SIDM00274	STAD\|stomach	p.H179Q (No)	GDSC	MIRA-1	416.45
SIDM00114	MESO\|mesothelioma	p.N239fs*25 (No)	GDSC	MIRA-1	502.69
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.C242S (No)	GDSC	MIRA-1	196.93
SIDM00613	LGG\|glioma	p.S241F (No)	GDSC	MIRA-1	216.42
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.R273C (No)	GDSC	MIRA-1	140.01
SIDM00529	BRCA\|breast	p.A88fs*52 (Yes)	GDSC	MIRA-1	224.07
SIDM01006	MM\|haematopoietic_neoplasm_other	p.C135Y (No)	GDSC	MIRA-1	77.984
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.R209* (No)	GDSC	MIRA-1	393.7
SIDM01088	UNCLASSIFIED\|endometrium	p.V73fs*50 (No)	GDSC	MIRA-1	203.54
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.I251N (No)	GDSC	MIRA-1	430.64
SIDM00842	COREAD\|large_intestine	p.R248W (No)	GDSC	MIRA-1	115.84
SIDM00363	LAML\|acute_myeloid_leukaemia	p.Y236C (No)	GDSC	MIRA-1	82.462
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R196* (No)	GDSC	MIRA-1	82.462
SIDM00150	COREAD\|large_intestine	p.H179R (No)	GDSC	MIRA-1	263.63
SIDM01024	ESCA\|oesophagus	p.I251fs*13 (No)	GDSC	MIRA-1	809.31
SIDM00469	PAAD\|pancreas	p.K132Q (No)	GDSC	MIRA-1	301.26
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.R273L (No)	GDSC	MIRA-1	194.38
SIDM00660	COREAD\|large_intestine	p.Y126* (No)	GDSC	MIRA-1	317.27
SIDM00182	HNSC\|head_and_neck	p.H179R (No)	GDSC	MIRA-1	616.39
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.G245C (No)	GDSC	MIRA-1	155.92
SIDM00922	LUAD\|lung_NSCLC_adenocarcinoma	p.M237I (No)	GDSC	MIRA-1	470.5
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.H214R (No)	GDSC	MIRA-1	127.51
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.V147D (No)	GDSC	MIRA-1	127.51
SIDM01066	SKCM\|melanoma	p.C229fs*10 (No)	GDSC	MIRA-1	111.77
SIDM00928	BRCA\|breast	p.K132E (No)	GDSC	MIRA-1	190.43
SIDM01137	PAAD\|pancreas	p.G245S (No)	GDSC	MIRA-1	4997.8
SIDM00589	HNSC\|head_and_neck	p.R306fs*1 (No)	GDSC	MIRA-1	217.41
SIDM00197	UNCLASSIFIED\|ewings_sarcoma	p.C176F (No)	GDSC	MIRA-1	147.24
SIDM01100	NB\|neuroblastoma	p.R110L (No)	GDSC	MIRA-1	236.3
SIDM00321	UNCLASSIFIED\|ovary	p.R175H (No)	GDSC	MIRA-1	625.15
SIDM00587	UNCLASSIFIED\|biliary_tract	p.R175H (No)	GDSC	MIRA-1	305.76
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K291* (No)	GDSC	MIRA-1	585.34
SIDM00882	BRCA\|breast	p.Y220C (No)	GDSC	MIRA-1	200.72
SIDM00886	DLBC\|B_cell_lymphoma	p.R248Q (No)	GDSC	MIRA-1	97.405
SIDM00886	DLBC\|B_cell_lymphoma	p.R248W (No)	GDSC	MIRA-1	97.405
SIDM01147	STAD\|stomach	p.R248Q (No)	GDSC	MIRA-1	476.56
SIDM00847	UNCLASSIFIED\|rhabdomyosarcoma	p.R248W (No)	GDSC	MIRA-1	175.82
SIDM01050	UNCLASSIFIED\|biliary_tract	p.R273H (No)	GDSC	MIRA-1	1259.5
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.R158L (No)	GDSC	MIRA-1	6233
SIDM00673	BRCA\|breast	p.R248Q (No)	GDSC	MIRA-1	107.73
SIDM00501	HNSC\|head_and_neck	p.P177L (No)	GDSC	MIRA-1	591.05
SIDM00501	HNSC\|head_and_neck	p.C176F (No)	GDSC	MIRA-1	591.05
SIDM00501	HNSC\|head_and_neck	p.Q38* (No)	GDSC	MIRA-1	591.05
SIDM00097	BRCA\|breast	p.L194F (No)	GDSC	MIRA-1	393.63
SIDM00359	COREAD\|large_intestine	p.R306* (No)	GDSC	MIRA-1	666.02
SIDM01145	STAD\|stomach	p.Y205F (No)	GDSC	MIRA-1	71.092
SIDM01245	ALL\|lymphoblastic_leukemia	p.Y163C (No)	GDSC	MIRA-1	112.82
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.K120fs*3 (No)	GDSC	MIRA-1	286.93
SIDM00580	LAML\|acute_myeloid_leukaemia	p.C242fs*5 (No)	GDSC	MIRA-1	83.745
SIDM00379	GBM\|glioma	p.F113C (No)	GDSC	MIRA-1	345.9
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R196* (No)	GDSC	MIRA-1	8.4258
SIDM00247	STAD\|stomach	p.R110C (No)	GDSC	MIRA-1	345.78
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R273L (No)	GDSC	MIRA-1	564.79
SIDM00996	THCA\|thyroid	p.R248G (No)	GDSC	MIRA-1	586.64
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.G266E (No)	GDSC	MIRA-1	77.326
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.S240R (No)	GDSC	MIRA-1	207.29
SIDM00322	ESCA\|oesophagus	p.E258* (No)	GDSC	MIRA-1	150.13
SIDM00322	ESCA\|oesophagus	p.H214R (No)	GDSC	MIRA-1	150.13
SIDM00475	OV\|ovary	p.K101fs*47 (Yes)	GDSC	MIRA-1	689.31
SIDM00125	KIRC\|kidney	p.P278A (No)	GDSC	MIRA-1	177.72
SIDM00375	HNSC\|head_and_neck	p.G154V (No)	GDSC	MIRA-1	305.02
SIDM00375	HNSC\|head_and_neck	p.S106R (Yes)	GDSC	MIRA-1	305.02
SIDM00987	THCA\|thyroid	p.I251T (No)	GDSC	MIRA-1	214.49
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.H179Q (No)	GDSC	MIRA-1	39.393
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.R280S (No)	GDSC	MIRA-1	160.29
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.R273C (No)	GDSC	MIRA-1	160.29
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.Y205C (No)	GDSC	MIRA-1	160.29
SIDM00458	LAML\|acute_myeloid_leukaemia	p.L145R (No)	GDSC	MIRA-1	38.98
SIDM00257	NB\|neuroblastoma	p.V173M (No)	GDSC	MIRA-1	63.734
SIDM00479	ESCA\|oesophagus	p.N310fs*27 (No)	GDSC	MIRA-1	421.31
SIDM00150	COREAD\|large_intestine	p.V73fs*50 (No)	GDSC	MIRA-1	263.63
SIDM00517	UNCLASSIFIED\|head_and_neck	p.R213* (No)	GDSC	MIRA-1	273.5
SIDM00413	DLBC\|B_cell_lymphoma	p.R248Q (No)	GDSC	MIRA-1	78.566
SIDM00132	PAAD\|pancreas	p.Y220C (No)	GDSC	MIRA-1	315.34
SIDM00866	BRCA\|breast	p.R248Q (No)	GDSC	MIRA-1	943.67
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G245C (No)	GDSC	MIRA-1	155.35
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.Y220C (No)	GDSC	MIRA-1	91.43
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.C141W (No)	GDSC	MIRA-1	151.29
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.G244D (No)	GDSC	MIRA-1	145.56
SIDM00789	COREAD\|large_intestine	p.S241F (No)	GDSC	MIRA-1	279.95
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R213* (No)	GDSC	MIRA-1	761.95
SIDM00273	LGG\|glioma	p.C275Y (No)	GDSC	MIRA-1	142.1
SIDM01080	HNSC\|head_and_neck	p.C275fs*20 (No)	GDSC	MIRA-1	255.81
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Q167* (No)	GDSC	MIRA-1	623.77
SIDM00371	PAAD\|pancreas	p.R273H (No)	GDSC	MIRA-1	1532.4
SIDM00487	COREAD\|large_intestine	p.P278H (No)	GDSC	MIRA-1	115.04
SIDM00861	UNCLASSIFIED\|ovary	p.S241F (No)	GDSC	MIRA-1	370
SIDM00642	SCLC\|lung_small_cell_carcinoma	p.R175fs*72 (No)	GDSC	MIRA-1	211.98
SIDM00591	HNSC\|head_and_neck	p.G293fs*13 (No)	GDSC	MIRA-1	198.32
SIDM00414	BLCA\|bladder	p.R175H (No)	GDSC	MIRA-1	206.64
SIDM01041	ESCA\|oesophagus	p.C277F (No)	GDSC	MIRA-1	197.69
SIDM00963	BRCA\|breast	p.E285K (No)	GDSC	MIRA-1	773.72
SIDM00583	PAAD\|pancreas	p.R273H (No)	GDSC	MIRA-1	419.46
SIDM01008	DLBC\|B_cell_lymphoma	p.K319* (No)	GDSC	MIRA-1	143.45
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.R248L (No)	GDSC	MIRA-1	138.94
SIDM00136	COREAD\|large_intestine	p.R273H (No)	GDSC	MIRA-1	1259
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.G244S (No)	GDSC	MIRA-1	93.039
SIDM00585	LIHC\|liver	p.Y220C (No)	GDSC	MIRA-1	518.98
SIDM01003	ALL\|lymphoblastic_leukemia	p.P153fs*28 (No)	GDSC	MIRA-1	59.62
SIDM00485	HNSC\|head_and_neck	p.F109fs*37 (No)	GDSC	MIRA-1	133.28
SIDM00582	PAAD\|pancreas	p.A161D (No)	GDSC	MIRA-1	532.38
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.V272M (No)	GDSC	MIRA-1	18.285
SIDM00502	DLBC\|B_cell_lymphoma	p.R249G (No)	GDSC	MIRA-1	78.042
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E294* (No)	GDSC	MIRA-1	186.33
SIDM00092	OV\|ovary	p.L130V (No)	GDSC	MIRA-1	553.67
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.G245C (No)	GDSC	MIRA-1	392.63
SIDM00343	GBM\|glioma	p.R282W (No)	GDSC	MIRA-1	553.45
SIDM00628	BRCA\|breast	p.R273H (No)	GDSC	MIRA-1	150.76
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q144* (No)	GDSC	MIRA-1	121.78
SIDM00545	SKCM\|melanoma	p.Q317* (No)	GDSC	MIRA-1	382.68
SIDM00545	SKCM\|melanoma	p.E258K (No)	GDSC	MIRA-1	382.68
SIDM00127	HNSC\|head_and_neck	p.S99fs*24 (Yes)	GDSC	MIRA-1	779.44
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y107* (Yes)	GDSC	MIRA-1	300.71
SIDM01183	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.D228fs*19 (No)	GDSC	MIRA-1	317.65
SIDM00120	PRAD\|prostate	p.V274F (No)	GDSC	MIRA-1	370.68
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y220C (No)	GDSC	MIRA-1	400.85
SIDM00560	STAD\|stomach	p.P278S (No)	GDSC	MIRA-1	764.79
SIDM00181	BLCA\|bladder	p.S241Y (No)	GDSC	MIRA-1	181.53
SIDM00407	DLBC\|B_cell_lymphoma	p.Y234C (No)	GDSC	MIRA-1	29.583
SIDM00241	BRCA\|breast	p.G244S (No)	GDSC	MIRA-1	67.596
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.V157F (No)	GDSC	MIRA-1	399.34
SIDM00541	COREAD\|large_intestine	p.R213L (No)	GDSC	MIRA-1	349.4
SIDM00616	LIHC\|liver	p.R249S (No)	GDSC	MIRA-1	530.48
SIDM00328	ESCA\|oesophagus	p.R248Q (No)	GDSC	MIRA-1	421.5
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R273H (No)	GDSC	MIRA-1	28.889
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R267L (No)	GDSC	MIRA-1	28.889
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R248Q (No)	GDSC	MIRA-1	28.889
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S215C (No)	GDSC	MIRA-1	2.8118
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V272M (No)	GDSC	MIRA-1	222.33
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.C242F (No)	GDSC	MIRA-1	247.7
SIDM01233	COREAD\|large_intestine	p.E204* (No)	GDSC	MIRA-1	808.32
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.R248Q (No)	GDSC	MIRA-1	28.543
SIDM00934	PAAD\|pancreas	p.A159V (No)	GDSC	MIRA-1	513.96
SIDM00528	BRCA\|breast	p.E56* (No)	GDSC	MIRA-1	192.77
SIDM00225	SKCM\|melanoma	p.R248W (No)	GDSC	MIRA-1	232.68
SIDM00225	SKCM\|melanoma	p.N247K (No)	GDSC	MIRA-1	232.68
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.H179R (No)	GDSC	MIRA-1	2432.7
SIDM00992	THCA\|thyroid	p.D259Y (No)	GDSC	MIRA-1	460.65
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D259V (No)	GDSC	MIRA-1	455.63
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E298* (No)	GDSC	MIRA-1	380.5
SIDM01151	LIHC\|liver	p.S215I (No)	GDSC	MIRA-1	678.53
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R273H (No)	GDSC	MIRA-1	5.43
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R273C (No)	GDSC	MIRA-1	5.43
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R248Q (No)	GDSC	MIRA-1	5.43
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.R273H (No)	GDSC	MIRA-1	392.81
SIDM00445	ESCA\|oesophagus	p.Q192* (No)	GDSC	MIRA-1	200.61
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.E285K (No)	GDSC	MIRA-1	557.99
SIDM00779	COREAD\|large_intestine	p.E224D (No)	GDSC	MIRA-1	368.24
SIDM01171	GBM\|glioma	p.M237I (No)	GDSC	MIRA-1	156.5
SIDM00064	LIHC\|liver	p.G244A (No)	GDSC	MIRA-1	138.75
SIDM00960	COREAD\|large_intestine	p.R248Q (No)	GDSC	MIRA-1	319.22
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.C176F (No)	GDSC	MIRA-1	124.08
SIDM01023	LAML\|acute_myeloid_leukaemia	p.R273H (No)	GDSC	MIRA-1	68.365
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R248Q (No)	GDSC	MIRA-1	229.08
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R175H (No)	GDSC	MIRA-1	229.08
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.R213* (No)	GDSC	MIRA-1	147.56
SIDM00503	STAD\|stomach	p.Y220D (No)	GDSC	MIRA-1	158.2
SIDM00417	MM\|myeloma	p.A161T (No)	GDSC	MIRA-1	23.477
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.H193R (No)	GDSC	MIRA-1	477.41
SIDM01182	BLCA\|bladder	p.F113C (No)	GDSC	MIRA-1	118.24
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.C176F (No)	GDSC	MIRA-1	63.878
SIDM00354	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S37fs*70 (No)	GDSC	MIRA-1	293.02
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.R248W (No)	GDSC	MIRA-1	126.06
SIDM00561	UNCLASSIFIED\|hairy_cell_leukaemia	p.R280G (No)	GDSC	MIRA-1	30.62
SIDM01111	UNCLASSIFIED\|ewings_sarcoma	p.C176F (No)	GDSC	MIRA-1	65.61
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.K319* (No)	GDSC	MIRA-1	74.042
SIDM00491	THCA\|thyroid	p.H179R (No)	GDSC	MIRA-1	215.71
SIDM00444	ESCA\|oesophagus	p.R248Q (No)	GDSC	MIRA-1	163.57
SIDM00481	OV\|ovary	p.P152fs*18 (No)	GDSC	MIRA-1	594.51
SIDM00306	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q192* (No)	GDSC	MIRA-1	292.5
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.R175H (No)	GDSC	MIRA-1	644.67
SIDM00899	PAAD\|pancreas	p.C135fs*35 (No)	GDSC	MIRA-1	3082.7
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.R156P (No)	GDSC	MIRA-1	117.38
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R249S (No)	GDSC	MIRA-1	241.73
SIDM00921	LUAD\|lung_NSCLC_adenocarcinoma	p.R196* (No)	GDSC	MIRA-1	494.03
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.R213* (No)	GDSC	MIRA-1	107.75
SIDM01081	HNSC\|head_and_neck	p.P151S (No)	GDSC	MIRA-1	200.87
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.W146* (No)	GDSC	MIRA-1	402.79
SIDM00539	ESCA\|oesophagus	p.R248W (No)	GDSC	MIRA-1	250.41
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.C176Y (No)	GDSC	MIRA-1	197.18
SIDM00983	BLCA\|bladder	p.E336* (No)	GDSC	MIRA-1	261.85
SIDM00983	BLCA\|bladder	p.I162N (No)	GDSC	MIRA-1	261.85
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.R273C (No)	GDSC	MIRA-1	217.16
SIDM00834	COREAD\|large_intestine	p.R248Q (No)	GDSC	MIRA-1	187.95
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R273C (No)	GDSC	MIRA-1	227.46
SIDM00135	BRCA\|breast	p.V157F (No)	GDSC	MIRA-1	159.47
SIDM00884	BRCA\|breast	p.R175H (No)	GDSC	MIRA-1	253.07
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.E294* (No)	GDSC	MIRA-1	199.42
SIDM00942	HNSC\|head_and_neck	p.R175H (No)	GDSC	MIRA-1	242.38
SIDM01170	OV\|ovary	p.R175H (No)	GDSC	MIRA-1	178.08
SIDM01259	ALL\|lymphoblastic_leukemia	p.M246T (No)	GDSC	MIRA-1	174.64
SIDM01002	BRCA\|breast	p.E271fs*1 (No)	GDSC	MIRA-1	383.85
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.Y220C (No)	GDSC	MIRA-1	301.61
SIDM00892	BRCA\|breast	p.M246I (No)	GDSC	MIRA-1	2262.5
SIDM00457	MM\|myeloma	p.R175H (No)	GDSC	MIRA-1	37.684
SIDM01027	ESCA\|oesophagus	p.E339* (No)	GDSC	MIRA-1	314.8
SIDM01027	ESCA\|oesophagus	p.H179R (No)	GDSC	MIRA-1	314.8
SIDM01040	OV\|ovary	p.H179D (No)	GDSC	MIRA-1	343.01
SIDM00659	GBM\|glioma	p.E286K (No)	GDSC	MIRA-1	120.21
SIDM00423	DLBC\|B_cell_lymphoma	p.R249G (No)	GDSC	MIRA-1	40.909
SIDM00423	DLBC\|B_cell_lymphoma	p.Y234N (No)	GDSC	MIRA-1	40.909
SIDM00105	OV\|ovary	p.R248Q (No)	GDSC	MIRA-1	358.65
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.K132Q (No)	GDSC	MIRA-1	6.9967
SIDM00317	KIRC\|kidney	p.D48fs*74 (No)	GDSC	MIRA-1	1834.1
SIDM00374	DLBC\|B_cell_lymphoma	p.V31I (No)	GDSC	MIRA-1	111.24
SIDM00237	LUAD\|lung_NSCLC_adenocarcinoma	p.R248Q (No)	GDSC	MIRA-1	2059.4
SIDM00278	ESCA\|oesophagus	p.R273L (No)	GDSC	MIRA-1	219.21
SIDM00278	ESCA\|oesophagus	p.Y234C (No)	GDSC	MIRA-1	219.21
SIDM00054	PAAD\|pancreas	p.R267W (No)	GDSC	MIRA-1	441.35
SIDM00496	THCA\|thyroid	p.P152L (No)	GDSC	MIRA-1	390.36
SIDM00944	COREAD\|large_intestine	p.S215N (No)	GDSC	MIRA-1	1476.3
SIDM01062	BRCA\|breast	p.R213* (No)	GDSC	MIRA-1	313.3
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S241F (No)	GDSC	MIRA-1	241.46
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.R181C (No)	GDSC	MIRA-1	51.252
SIDM00332	BRCA\|breast	p.K132R (No)	GDSC	MIRA-1	1333.8
SIDM00835	COREAD\|large_intestine	p.A159D (No)	GDSC	MIRA-1	693.48
SIDM00920	BRCA\|breast	p.R280T (No)	GDSC	MIRA-1	152.97
SIDM00693	BLCA\|bladder	p.E271K (No)	GDSC	MIRA-1	942.92
SIDM00531	PAAD\|pancreas	p.I255T (No)	GDSC	MIRA-1	338.03
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N345fs*24 (No)	GDSC	MIRA-1	41.359
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.Y220C (No)	GDSC	MIRA-1	90.777
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.R273C (No)	GDSC	MIRA-1	62.486
SIDM00679	CESC\|cervix	p.E285K (No)	GDSC	MIRA-1	421.4
SIDM00679	CESC\|cervix	p.G245V (No)	GDSC	MIRA-1	421.4
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.S315fs*30 (No)	GDSC	MIRA-1	346.42
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.A119fs*5 (No)	GDSC	MIRA-1	100.15
SIDM00900	MM\|myeloma	p.R273H (No)	GDSC	MIRA-1	9.9497
SIDM00579	NB\|neuroblastoma	p.F113L (No)	GDSC	MIRA-1	16.813
SIDM00118	COREAD\|large_intestine	p.R213* (No)	GDSC	MIRA-1	140.93
SIDM01248	THCA\|thyroid	p.I255S (No)	GDSC	MIRA-1	120.11
SIDM01109	UNCLASSIFIED\|soft_tissue_other	p.G245S (No)	GDSC	MIRA-1	242.4
SIDM01109	UNCLASSIFIED\|soft_tissue_other	p.M237K (No)	GDSC	MIRA-1	242.4
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.E224D (No)	GDSC	MIRA-1	362
SIDM01149	SCLC\|lung_small_cell_carcinoma	p.R158L (No)	GDSC	MIRA-1	68.311
SIDM00832	COREAD\|large_intestine	p.T118fs*5 (No)	GDSC	MIRA-1	545.02
SIDM00860	HNSC\|head_and_neck	p.R248L (No)	GDSC	MIRA-1	240.82
SIDM00472	OV\|ovary	p.G244D (No)	GDSC	MIRA-1	298.06
SIDM00581	GBM\|glioma	p.N239_S240insN (No)	GDSC	MIRA-1	39.884
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.V216L (No)	GDSC	MIRA-1	266.78
SIDM00841	COREAD\|large_intestine	p.P309S (No)	GDSC	MIRA-1	2337
SIDM01188	PAAD\|pancreas	p.G360V (No)	GDSC	MIRA-1	2173.3
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.C238F (No)	GDSC	MIRA-1	31.956
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.Q165_S166insYKQ (No)	GDSC	MIRA-1	586.42
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.E11Q (No)	GDSC	MIRA-1	2.225
SIDM00901	UCEC\|endometrium	p.G389W (No)	GDSC	MIRA-1	65.639
SIDM01007	ALL\|lymphoblastic_leukemia	p.T125M (No)	GDSC	MIRA-1	82.935
SIDM00098	MESO\|mesothelioma	p.I232S (No)	GDSC	MIRA-1	168.85
SIDM00381	CESC\|cervix	p.V173L (No)	GDSC	MIRA-1	290.38
SIDM00312	MM\|myeloma	p.S261T (No)	GDSC	MIRA-1	94.018
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.S215delS (No)	GDSC	MIRA-1	637.12
SIDM00292	SCLC\|lung_small_cell_carcinoma	p.V157fs*9 (No)	GDSC	MIRA-1	608.22
SIDM00498	COREAD\|large_intestine	p.V218L (No)	GDSC	MIRA-1	396.32
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.H233delH (No)	GDSC	MIRA-1	62.533
SIDM00885	BRCA\|breast	p.G108delG (No)	GDSC	MIRA-1	209.39
SIDM00946	ALL\|T_cell_leukemia	p.P301fs*44 (No)	GDSC	MIRA-1	70.626
SIDM00485	HNSC\|head_and_neck	p.A307V (No)	GDSC	MIRA-1	133.28
SIDM00054	PAAD\|pancreas	p.E171delE (No)	GDSC	MIRA-1	441.35
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.K164E (No)	GDSC	MIRA-1	46.14
SIDM01055	LGG\|glioma	p.L265P (No)	GDSC	MIRA-1	159.45
SIDM00324	NB\|neuroblastoma	p.R283delR (No)	GDSC	MIRA-1	113.24
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.0 (No)	GDSC	MIRA-1	317.04
SIDM00333	UCEC\|endometrium	p.A74S (No)	GDSC	MIRA-1	249.98
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y234fs*2 (No)	GDSC	MIRA-1	1336
SIDM00274	STAD\|stomach	p.E11Q (No)	GDSC	MIRA-1	416.45
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.G112_V122delGFLHSGTAKSV (No)	GDSC	MIRA-1	129.46
SIDM01088	UNCLASSIFIED\|endometrium	p.V218delV (No)	GDSC	MIRA-1	203.54
SIDM01052	OV\|ovary	p.C124R (No)	GDSC	MIRA-1	1914.3
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.P36L (No)	GDSC	MIRA-1	564.79
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.P36S (No)	GDSC	MIRA-1	564.79
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P301fs*44 (No)	GDSC	MIRA-1	115.42
SIDM00812	COREAD\|large_intestine	p.C238fs*21 (No)	GDSC	MIRA-1	2025.4
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.A347P (No)	GDSC	MIRA-1	155.35
SIDM00615	LIHC\|liver	p.E336fs*7 (No)	GDSC	MIRA-1	673.14
SIDM00670	PAAD\|pancreas	p.G187R (No)	GDSC	MIRA-1	3096.9
SIDM00520	MESO\|mesothelioma	p.Q192_H193delQH (No)	GDSC	MIRA-1	311.47
SIDM00120	PRAD\|prostate	p.P223L (No)	GDSC	MIRA-1	370.68
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.E286_E287delEE (No)	GDSC	MIRA-1	122.06
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.Q16L (No)	GDSC	MIRA-1	124.08
SIDM00218	THCA\|thyroid	p.P223L (No)	GDSC	MIRA-1	2898.5
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E11Q (No)	GDSC	MIRA-1	232.35
SIDM00426	UNCLASSIFIED\|rhabdomyosarcoma	p.P152fs*14 (No)	GDSC	MIRA-1	135.59
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.K164N (No)	GDSC	MIRA-1	270.59
SIDM00291	SKCM\|melanoma	p.N268I (No)	GDSC	MIRA-1	324.6
SIDM00684	GBM\|glioma	p.P98L (Yes)	GDSC	MIRA-1	551.54
SIDM00826	COREAD\|large_intestine	p.Y103_R110delYQGSYGFR (Yes)	GDSC	MIRA-1	159.62
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V218delV (No)	GDSC	MIRA-1	1203
SIDM00113	KIRC\|kidney	p.L264R (No)	GDSC	MIRA-1	819.58
SIDM00540	HNSC\|head_and_neck	p.L188_P191delLAPP (No)	GDSC	MIRA-1	101.97
SIDM00693	BLCA\|bladder	p.K320N (No)	GDSC	MIRA-1	942.92
SIDM01087	SKCM\|melanoma	p.S166* (No)	GDSC	MIRA-1	76.742

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_SPOP_SBC_1	103:107	PLSSS	SPOP	0.9873	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	239:243	PLSSS	SPOP	0.9749	More...
O60825	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	DEG_SPOP_SBC_1	469:473	PLSSS	SPOP	0.9968	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	829:833	PLSSS	SPOP	0.9934	More...
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_SPOP_SBC_1	685:689	PLSSS	SPOP	0.9688	More...
P04637	Cellular tumor antigen p53	DEG_SPOP_SBC_1	92:96	PLSSS	SPOP	0.9977	More...
P11388	DNA topoisomerase 2-alpha	DEG_SPOP_SBC_1	1389:1393	PLSSS	SPOP	0.9972	More...
P14316	Interferon regulatory factor 2	DEG_SPOP_SBC_1	312:316	PLSSS	SPOP	0.9872	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	185:189	PLSSS	SPOP	0.9793	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	574:578	PLSSS	SPOP	0.9943	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	288:292	PLSSS	SPOP	0.9368	More...
Q13470	Non-receptor tyrosine-protein kinase TNK1	DEG_SPOP_SBC_1	541:545	PLSSS	SPOP	0.9727	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3634:3638	PLSSS	SPOP	0.9557	More...
Q2TBE0	CWF19-like protein 2	DEG_SPOP_SBC_1	388:392	PLSSS	SPOP	0.9997	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	77:81	PLSSS	SPOP	0.9962	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	114:118	PLSSS	SPOP	0.9937	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	1473:1477	PLSSS	SPOP	0.9884	More...
Q6ZN55	Zinc finger protein 574	DEG_SPOP_SBC_1	118:122	PLSSS	SPOP	0.9413	More...
Q6ZQX7	Protein LIAT1	DEG_SPOP_SBC_1	113:117	PLSSS	SPOP	0.961	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1434:1438	PLSSS	SPOP	0.9226	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	509:513	PLSSS	SPOP	0.9784	More...
Q8IVF2	Protein AHNAK2	DEG_SPOP_SBC_1	4735:4739	PLSSS	SPOP	0.6704	More...
Q8IZ21	Phosphatase and actin regulator 4	DEG_SPOP_SBC_1	174:178	PLSSS	SPOP	0.636	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	247:251	PLSSS	SPOP	0.9926	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1354:1358	PLSSS	SPOP	0.959	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	248:252	PLSSS	SPOP	0.8247	More...
Q92993	Histone acetyltransferase KAT5	DEG_SPOP_SBC_1	133:137	PLSSS	SPOP	0.9685	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	573:577	PLSSS	SPOP	0.9968	More...
Q96MU7	YTH domain-containing protein 1	DEG_SPOP_SBC_1	73:77	PLSSS	SPOP	0.9922	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	478:482	PLSSS	SPOP	0.779	More...
Q9NS37	CREB/ATF bZIP transcription factor	DEG_SPOP_SBC_1	129:133	PLSSS	SPOP	0.9398	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	1112:1116	PLSSS	SPOP	0.9707	More...
Q9NXE4	Sphingomyelin phosphodiesterase 4	DEG_SPOP_SBC_1	244:248	PLSSS	SPOP	0.5515	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	1226:1230	PLSSS	SPOP	0.982	More...
Q9P0L1	Zinc finger protein with KRAB and SCAN domains 7	DEG_SPOP_SBC_1	365:369	PLSSS	SPOP	0.9637	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	615:619	PLSSS	SPOP	0.9976	More...
Q9P2B4	CTTNBP2 N-terminal-like protein	DEG_SPOP_SBC_1	405:409	PLSSS	SPOP	0.9931	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	1734:1738	PLSSS	SPOP	0.9258	More...
Q9UBC0	Hepatocyte nuclear factor 6	DEG_SPOP_SBC_1	181:185	PLSSS	SPOP	0.5617	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	311:315	PLSSS	SPOP	0.9014	More...
Q9ULK0	Glutamate receptor ionotropic, delta-1	DEG_SPOP_SBC_1	954:958	PLSSS	SPOP	0.9853	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1507:1511	PLSSS	SPOP	0.9967	More...
Q9UPX0	Protein turtle homolog B	DEG_SPOP_SBC_1	914:918	PLSSS	SPOP	0.9928	More...
Q9Y4D2	Diacylglycerol lipase-alpha	DEG_SPOP_SBC_1	993:997	PLSSS	SPOP	0.7658	More...
Q9Y5Y9	Sodium channel protein type 10 subunit alpha	DEG_SPOP_SBC_1	952:956	PLSSS	SPOP	0.9773	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	69:73	PLSSS	SPOP	0.8794	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	670:674	PLSSS	SPOP	0.9963	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	32:36	PLSSS	SPOP	0.972	More...
Q9UN71	Protocadherin gamma-B4	DEG_SPOP_SBC_1	429:433	PLSSS	SPOP	0.7211	More...
Q9Y5F8	Protocadherin gamma-B7	DEG_SPOP_SBC_1	431:435	PLSSS	SPOP	0.7253	More...
Q9Y5G0	Protocadherin gamma-B5	DEG_SPOP_SBC_1	427:431	PLSSS	SPOP	0.8178	More...
Q9Y5G2	Protocadherin gamma-B2	DEG_SPOP_SBC_1	431:435	PLSSS	SPOP	0.6125	More...
Q6ZMS4	Zinc finger protein 852	DEG_SPOP_SBC_1	141:145	PLSSS	SPOP	0.745	More...
Q6ZV89	SH2 domain-containing protein 5	DEG_SPOP_SBC_1	171:175	PLSSS	SPOP	0.9938	More...
Q8N9Z9	Lamin tail domain-containing protein 1	DEG_SPOP_SBC_1	35:39	PLSSS	SPOP	0.8742	More...
Q96N46	Tetratricopeptide repeat protein 14	DEG_SPOP_SBC_1	578:582	PLSSS	SPOP	0.8795	More...
Q96RY5	Protein cramped-like	DEG_SPOP_SBC_1	1056:1060	PLSSS	SPOP	0.9467	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	780:784	PLSSS	SPOP	0.9515	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	298:302	PLSSS	SPOP	0.9654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSSS

Degron related mutations and impact score

Drug responses associated with TP53 mutations

All proteins holding degron of PLSSS