DegronMD - P04637(TP53)

FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:9840937, PubMed:24652652). Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:9840937, PubMed:24652652). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). {ECO:0000269|PubMed:11025664, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15340061, ECO:0000269|PubMed:17317671, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:19556538, ECO:0000269|PubMed:20673990, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:24051492, ECO:0000269|PubMed:24652652, ECO:0000269|PubMed:9840937}. View more >>

GO - Biological processes (BP): autophagy [GO:0006914]; B cell lineage commitment [GO:0002326]; bone marrow development [GO:0048539]; cardiac septum morphogenesis [GO:0060411]; cell aging [GO:0007569]; cellular protein localization [GO:0034613]; cellular response to actinomycin D [GO:0072717]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; cellular response to UV-C [GO:0071494]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; chromatin assembly [GO:0031497]; circadian behavior [GO:0048512]; determination of adult lifespan [GO:0008340]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; embryonic organ development [GO:0048568]; entrainment of circadian clock by photoperiod [GO:0043153]; ER overload response [GO:0006983]; gastrulation [GO:0007369]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; in utero embryonic development [GO:0001701]; mitochondrial DNA repair [GO:0043504]; mitotic G1 DNA damage checkpoint signaling [GO:0031571]; mRNA transcription [GO:0009299]; multicellular organism growth [GO:0035264]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1 to G0 transition [GO:1903451]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of helicase activity [GO:0051097]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of pentose-phosphate shunt [GO:1905856]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of proteolysis [GO:0045861]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair [GO:0006289]; oligodendrocyte apoptotic process [GO:0097252]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell aging [GO:0090343]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of gene expression [GO:0010628]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800]; positive regulation of programmed necrotic cell death [GO:0062100]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of RNA polymerase II transcription preinitiation complex assembly [GO:0045899]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; protein-containing complex assembly [GO:0065003]; protein import into nucleus [GO:0006606]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; protein tetramerization [GO:0051262]; Ras protein signal transduction [GO:0007265]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of cellular senescence [GO:2000772]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of fibroblast apoptotic process [GO:2000269]; regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902253]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108]; regulation of tissue remodeling [GO:0034103]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to DNA damage [GO:1990248]; release of cytochrome c from mitochondria [GO:0001836]; replicative senescence [GO:0090399]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to salt stress [GO:0009651]; response to X-ray [GO:0010165]; rRNA transcription [GO:0009303]; signal transduction by p53 class mediator [GO:0072331]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell proliferation involved in immune response [GO:0002309]; transforming growth factor beta receptor signaling pathway [GO:0007179]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; viral process [GO:0016032] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G105D	TCGA-05-4398	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105D	TCGA-95-8039	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105D	DO25847	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105D	DO51197	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	TCGA-13-1494	OV	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	TCGA-34-2604	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	TCGA-49-AAR4	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	TCGA-77-6843	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	TCGA-CV-7413	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	TCGA-DK-AA6U	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO219008	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO15567	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO218920	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO26433	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO27588	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO32698	OV	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	DO224705	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105C	SIDM01280	Esophageal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105R	TCGA-14-1034	GBM	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105R	TCGA-20-0987	OV	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105R	DO11148	GBM	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105R	DO31210	OV	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105R	ACH-000419	Myeloma	CCLE	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105R	ACH-001541	Myeloma	CCLE	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.Q104H	TCGA-17-Z031	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.G105S	TCGA-56-7730	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105S	DO229263	LMS	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105S	DO26617	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	TCGA-63-A5MW	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	TCGA-77-8139	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	TCGA-BA-A6DL	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	TCGA-CN-A6V3	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO233184	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO52050	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO52035	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO228192	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO26524	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO219169	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G105V	DO229068	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.S106R	TCGA-98-A53I	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	TCGA-CR-7390	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	TCGA-DD-AADV	LIHC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	TCGA-UF-A7JO	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	TCGA-XP-A8T8	ESCA	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	DO219088	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	DO14302	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	DO219573	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	DO23462	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	DO219182	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	DO49183	PACA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	SIDM00375	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	ACH-002305	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.S106R	SKN-3	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.E11K	TCGA-AN-A046	BRCA	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11K	DO1285	BRCA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.Q100K	TCGA-BQ-7049	KIRP	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Q100K	DO20853	KIRP	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Q100K	DO232049	ORCA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.P92S	TCGA-DF-A2KU	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6752
p.P92S	DO223286	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6752
p.P27S	TCGA-E2-A1B1	BRCA	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27S	TCGA-EE-A3AA	SKCM	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27S	TCGA-GN-A4U3	SKCM	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27S	DO3122	BRCA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27S	DO222632	MELA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27S	DO37571	SKCM	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27S	DO219484	SKCM	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27L	TCGA-GN-A8LK	SKCM	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27L	DO51259	SKCM	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27L	SIDM00955	Melanoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27L	ACH-000812	Skin Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.P27L	COLO-783	skin	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.V97D	TCGA-VQ-A8PP	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.V97D	DO51774	STAD	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.P82L	TCGA-XK-AAIW	PRAD	TCGA	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.P82L	DO51407	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.W23C	DO50979	LAML	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7
p.P92T	DO228952	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7031
p.A88D	DO228974	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.P92H	DO229045	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7694
p.P34L	DO50852	LICA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.S33F	DO50750	LICA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.5833
p.P87Q	DO232036	ORCA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.N30I	DO47088	RECA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2222
p.G105A	DO232131	RECA	ICGC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.P98L	SIDM00684	Glioblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.P98L	ACH-000595	Brain Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.P98L	LN-229	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.E11Q	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	SIDM00463	T-Lymphoblastic Leukemia	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	SIDM00274	Gastric Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	SIDM01694	B-Lymphoblastic Leukemia	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	ACH-000047	Gastric Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	ACH-000372	Leukemia	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	ACH-000438	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	ACH-000728	Leukemia	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	ACH-001609	Brain Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	LU-65	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.E11Q	GCIY	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.V31I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	SIDM00568	Gastric Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	SIDM01609	Endometrial Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	ACH-000247	Gastric Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	ACH-000972	Endometrial/Uterine Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	ACH-001538	Bile Duct Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	ACH-002062	Lymphoma	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	OCUM-1	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V31I	SLVL	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.Q16L	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.Q16L	ACH-000311	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.Q16L	NCI-H2122	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.S90F	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.P36L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.P36L	ACH-000744	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.P36L	NCI-H1623	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.P36S	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.P36S	ACH-000744	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.P36S	NCI-H1623	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.S95F	SIDM01617	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7982
p.S95F	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7982
p.E28Q	ACH-001395	Breast Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.P98S	ACH-001421	Eye Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.N88K	IST-MEL1	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.R16H	LS-123	large intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	AU565	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	VM-CUB-1	urinary tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	CAL-33	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	KY821	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	TOV-112D	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	EW-22	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	OPM-2	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	RERF-LC-FM	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	Detroit562	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	VMRC-LCD	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	NCI-H196	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	RXF393	kidney	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	COR-L321	NS	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	HCC1395	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	ES3	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	RKN	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	SNU-61	large intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	PCI-6A	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	SK-GT-2	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	ESO51	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	D-263MG	central nervous system	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	ETK-1	biliary tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	SK-UT-1	soft tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	HuCCT1	biliary tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	TYK-nu	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	PCI-4B	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16H	KLE	endometrium	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.K93R	KU812	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7237
p.K93R	DIFI	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7237
p.K93R	MFM-223	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7237
p.R89L	SBC-5	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89L	NCI-H1573	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89L	NCI-H322M	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89L	FADU	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.I100S	H2731	pleura	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.V84M	HT	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.V84M	ECC12	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.V84M	OV-17R	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.E92D	RERF-LC-KJ	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6758
p.E92D	NCI-H716	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6758
p.Y88C	HCC-366	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	HCC1419	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	RH-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	MFE-296	endometrium	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	MFE-319	endometrium	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	NCI-H748	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	U-698-M	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	NCI-H2342	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	BxPC-3	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	KON	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	HuH-7	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	NUGC-3	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	451Lu	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	NCI-H2085	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88C	MDA-MB-330	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.G86S	SU8686	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	DG-75	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	D-423MG	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	no-10	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	D-566MG	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	KINGS-1	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	HSC-39	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	LS-1034	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	SK-NEP-1	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	SK-LMS-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	D-542MG	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	SK-MEL-2	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86S	PANC-04-03	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G85D	EB2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.G85D	PEO1	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.G103S	NB7	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.S82F	KALS-1	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82F	MCC13	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82F	HCC-78	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82F	HCT-15	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82F	DMS-53	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82F	ES-2	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.H20D	FU-OV-1	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7688
p.G86V	HCE-4	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86V	CPC-N	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86V	HT-3	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.C17F	SK-PN-DW	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.C17F	EW-18	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.C17F	BICR78	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.C17F	NCI-H2122	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.C17F	SK-ES-1	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.R89Q	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	NB-4	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	639-V	urinary tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	KYSE-150	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	NCI-N87	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	PC-14	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	WM1552C	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	BL-41	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	HEC-1	endometrium	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	CA46	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	PE/CA-PJ15	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	ES5	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	RT-112	urinary tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	EM-2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	PANC-02-03	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	OACM5-1	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	DB	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	SF295	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	HCC1143	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	HCC70	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	NCI-H211	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	Hs683	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	KINGS-1	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	SK-UT-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	SW1463	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	CL-40	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	ES1	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	OVCAR-3	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	TE-6	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	PF-382	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89Q	HSC-4	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.C106S	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.C106S	LN-18	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.H20R	LB771-HNC	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.H20R	YAPC	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.H20R	NCI-H1568	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.H20R	KYSE-450	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.H20R	KM12	large intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.H20R	ASH-3	thyroid	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.H34L	CAL-27	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.H34L	HN	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.V25F	NCI-H2196	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.V25F	Hs-578-T	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.V25F	LU-139	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.V25F	COR-L88	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.V25F	NCI-H1781	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.V25F	NCI-H2087	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.V25F	NCI-H2066	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7068
p.C106Y	MC116	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.V104A	MKN1	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.V104A	HARA	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.C17W	SHP-77	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.C17W	NCI-H720	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.L13R	SK-MEL-28	skin	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1667
p.L13R	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1667
p.M105I	Calu-3	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.M105I	NCI-H1869	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.M105I	LC-1-sq	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.M105I	T98G	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.M105I	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.M105I	TE-8	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.Y104C	NCI-H345	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.Y104C	MDA-MB-415	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.Y104C	GMS-10	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.Y104C	NCI-H2444	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.Y104C	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.C83Y	HCC-33	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.C83Y	TE-10	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.C9W	NCI-H1435	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.5
p.E99K	Mewo	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.6944
p.E99K	SNB75	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.6944
p.R89W	Set2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	HCC2157	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	MIA-PaCa-2	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	LXF-289	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	GCT	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	D-336MG	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	COLO-680N	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	SW837	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	RCC-ER	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	COLO-320-HSR	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	BB65-RCC	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	JIMT-1	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	ESO26	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	Farage	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	KYSE-220	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	RD	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	VCaP	prostate	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	Ca9-22	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	SNU-1040	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	NCI-H1770	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	IST-MEL1	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	SNU-C5	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	CAS-1	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	DB	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.R89W	KO52	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.V14M	TMK-1	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V14M	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.V14M	NB13	autonomic ganglia	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.G85S	MS-1	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.G85S	OCUB-M	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.R26H	DSH1	urinary tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.R26H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.R26H	ST486	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.R26H	SW954	vulva	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8244
p.K93Q	PSN1	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6944
p.K93Q	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6944
p.K93Q	BT-20	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6944
p.I96N	PANC-10-05	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.728
p.P91L	RO82-W-1	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.P91L	HT-1376	urinary tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.P91L	DU-145	prostate	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.R24P	HOS	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8623
p.K93T	SNU-81	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7306
p.P20L	KYAE-1	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.P20L	SW962	vulva	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.P20L	GA-10	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.P20L	LAN-6	autonomic ganglia	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.P20L	HTC-C3	thyroid	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.H34R	EFM-19	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.H34R	KYSE-140	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.H34R	SK-LU-1	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.H34R	CHL-1	skin	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.M87R	SK-N-FI	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.I95N	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.728
p.V84L	LCLC-103H	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.V84L	Hs940-T	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.L91F	Sarc9371	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.R90S	NCI-H1105	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.R90S	JHH-4	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.R90S	BT-549	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.R90S	OSC-20	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.R90S	KNS-62	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.I92T	BHT-101	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7078
p.V104M	LOU-NH91	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.V104M	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1111
p.R26L	NCI-H847	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8428
p.R26L	NCI-H661	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8428
p.R26L	NCI-H747	large intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8428
p.R26L	NCI-H441	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8428
p.H34Y	SW13	adrenal gland	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.F95L	Sarc9371	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6981
p.S83R	OV-90	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.A29T	SNU-449	liver	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.A29T	U-266	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16L	HCC-44	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.R16L	HOP-92	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.G28R	HPAC	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.V11A	MKN1	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.V11A	HARA	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.T23N	NCI-H524	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7055
p.I96S	CGTH-W-1	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7341
p.A27V	MOG-G-CCM	central nervous system	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.A27V	CAPAN-1	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.Y88D	NCI-H2029	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.Y88D	FU97	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.I92L	MKN28	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7174
p.M94K	CMK	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.8062
p.M94K	HEL	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.8062
p.K93N	EJM	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6918
p.K93N	SKG-IIIa	cervix	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6918
p.K93N	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.6918
p.Y87D	A704	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.C83F	NCI-H1755	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.C83F	SKN	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.C83F	Daoy	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.S82A	201T	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.Y102C	NCI-H1304	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.Y102C	EC-GI-10	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.Y102C	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.C102W	NCI-H1435	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.S82C	NCI-H187	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82C	LC-2-ad	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82C	EVSA-T	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.S82C	BFTC-909	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.E92K	CAL-148	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7022
p.C96R	A704	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.8301
p.C96R	COLO-800	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.8301
p.S82Y	LB831-BLC	urinary tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.K93E	CAL-85-1	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7022
p.G86C	COLO-668	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86C	NCI-H596	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86C	DMS-273	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86C	TE-4	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.V11M	LOU-NH91	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.V11M	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1111
p.A29D	CAL-62	thyroid	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.A29D	KP-2	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.25
p.C96F	A388	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7108
p.C96F	CAL-12T	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7108
p.C96F	ES8	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7108
p.C96F	BE2-M17	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7108
p.C96F	KP-N-YS	autonomic ganglia	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7108
p.Y31C	NCI-H378	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.Y31C	BEN	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.Y31C	EB-3	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.Y31C	HCC1954	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.Y31C	BE-13	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.G85A	HLE	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.V15G	JHOS-4	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.6667
p.A35S	MFE-319	endometrium	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0833
p.P19H	CAL-39	vulva	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7694
p.G103D	SNU-475	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.D100V	HCC-15	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.M105K	SK-LMS-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.K32N	NCI-H650	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1667
p.I95S	OV-7	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7341
p.L106R	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.L106R	SK-MEL-28	skin	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.H20Q	GCIY	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.H20Q	NCI-H1436	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.H20Q	ES7	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7582
p.C85R	EFO-21	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.Y102N	SU-DHL-8	NS	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G22V	NCI-H446	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7532
p.G22V	SKN-3	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7532
p.G22V	NCI-H2291	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7532
p.A27D	SW1116	large intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.A27D	HUH-6-clone5	liver	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.3056
p.M87I	BT-483	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.M87I	NCI-H23	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.S83I	NCI-H661	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.S83I	SNU-182	liver	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.R22C	REH	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.8301
p.L105R	TK10	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.A99P	RL	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.6944
p.V14L	SKG-IIIa	cervix	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1944
p.C17Y	NCI-H1651	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.V86L	SNU-C5	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.D100Y	BCPAP	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.D100Y	COR-L95	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.C96Y	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7087
p.C96Y	OE33	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7087
p.D10H	CMK	haematopoietic and lymphoid tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0833
p.V15D	Caov-4	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.6667
p.V15D	NCI-H1963	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.6667
p.S83C	DEL	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.I95V	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7076
p.I100N	GA-10	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.S102T	L-363	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.L91V	OVCAR-4	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.L91V	ROS-50	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.3056
p.G85C	LU-135	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.G85C	NCI-H1836	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.T86M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.L35F	T47D	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0833
p.P19S	SCC-4	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.6752
p.P19S	HPAF-II	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.6752
p.C17S	PA-TU-8902	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2778
p.I92N	SW872	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.728
p.R26P	NCI-H2110	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7512
p.R89P	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.P18T	KELLY	autonomic ganglia	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.75
p.M87T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.R90G	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.R90G	SU-DHL-8	NS	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2778
p.C83R	CFPAC-1	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.H82R	NCI-H1963	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.H82R	T-T	oesophagus	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0556
p.I96T	HuP-T4	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation altering degron motif	0.7078
p.Y87C	IGROV-1	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1944
p.G86D	CS1	bone	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.G86D	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.S83N	CL-11	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.D9N	SNU-1040	large intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.5
p.C106F	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.R26G	NCI-H2170	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation altering degron motif	0.7568
p.R89G	8505C	thyroid	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.25
p.I36T	KYSE-180	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.0556
p.C83S	NCI-H841	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.G103V	SW626	ovary	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.G103V	NCI-H2030	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1389
p.S88P	CL-34	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.2222
p.L106P	GAMG	central nervous system	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation blocking phosphorylation signal	0.5
p.P18L	BICR78	upper aerodigestive tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation blocking phosphorylation signal	0.75
p.C83W	NCI-H1993	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.0833
p.I30N	647-V	urinary tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.2222
p.Y102H	Raji	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	92:96	Mutation rewiring degron network	0.1667
p.K32E	EW-24	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	19:26	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TP53

UniProt ID: P04637

Entrez ID: 7157

Protein name: Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TP53 in