DegronMD

Uniprot ID: P04637

Source protein: Cellular tumor antigen p53

Source gene: TP53

Class: DEG_MDM2_SWIB_1

Location: 19:26

E3 ligase: MDM2

DEGRON score: 0.9897

ASA_SCORE: 57.5625

COIL: 0.2598

CONS_SCORE: 0.3706

DSS_SCORE: 0.4341

HELIX: 0.7208

FCONS_SCORE: 1.1878

RIG_SCORE: 0.7954

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E11K	TCGA-AN-A046	BRCA	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11K	DO1285	BRCA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.P27S	TCGA-E2-A1B1	BRCA	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27S	TCGA-EE-A3AA	SKCM	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27S	TCGA-GN-A4U3	SKCM	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27S	DO3122	BRCA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27S	DO222632	MELA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27S	DO37571	SKCM	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27S	DO219484	SKCM	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27L	TCGA-GN-A8LK	SKCM	TCGA	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27L	DO51259	SKCM	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27L	SIDM00955	Melanoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27L	ACH-000812	Skin Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.P27L	COLO-783	skin	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.W23C	DO50979	LAML	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7
p.P34L	DO50852	LICA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.S33F	DO50750	LICA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.5833
p.N30I	DO47088	RECA	ICGC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2222
p.E11Q	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	SIDM00463	T-Lymphoblastic Leukemia	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	SIDM00274	Gastric Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	SIDM01694	B-Lymphoblastic Leukemia	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	ACH-000047	Gastric Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	ACH-000372	Leukemia	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	ACH-000438	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	ACH-000728	Leukemia	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	ACH-001609	Brain Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	LU-65	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.E11Q	GCIY	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.V31I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	SIDM00568	Gastric Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	SIDM01609	Endometrial Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	ACH-000247	Gastric Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	ACH-000972	Endometrial/Uterine Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	ACH-001538	Bile Duct Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	ACH-002062	Lymphoma	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	OCUM-1	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V31I	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.Q16L	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.Q16L	ACH-000311	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.Q16L	NCI-H2122	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.P36L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.P36L	ACH-000744	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.P36L	NCI-H1623	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.P36S	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.P36S	ACH-000744	Lung Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.P36S	NCI-H1623	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.E28Q	ACH-001395	Breast Cancer	CCLE	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.R16H	LS-123	large_intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	AU565	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	VM-CUB-1	urinary_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	CAL-33	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	TOV-112D	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	EW-22	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	RERF-LC-FM	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	Detroit562	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	VMRC-LCD	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	NCI-H196	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	RXF393	kidney	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	COR-L321	NS	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	HCC1395	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	ES3	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	RKN	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	SNU-61	large_intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	PCI-6A	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	SK-GT-2	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	ESO51	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	D-263MG	central_nervous_system	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	ETK-1	biliary_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	SK-UT-1	soft_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	HuCCT1	biliary_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	TYK-nu	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	PCI-4B	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16H	KLE	endometrium	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.H20D	FU-OV-1	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7688
p.C17F	SK-PN-DW	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.C17F	EW-18	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.C17F	BICR78	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.C17F	NCI-H2122	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.C17F	SK-ES-1	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.H20R	LB771-HNC	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.H20R	YAPC	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.H20R	NCI-H1568	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.H20R	KYSE-450	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.H20R	KM12	large_intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.H20R	ASH-3	thyroid	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.H34L	CAL-27	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.H34L	HN	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.V25F	NCI-H2196	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.V25F	Hs-578-T	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.V25F	LU-139	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.V25F	COR-L88	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.V25F	NCI-H1781	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.V25F	NCI-H2087	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.V25F	NCI-H2066	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7068
p.C17W	SHP-77	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.C17W	NCI-H720	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.L13R	SK-MEL-28	skin	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1667
p.L13R	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1667
p.C9W	NCI-H1435	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.5
p.V14M	TMK-1	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V14M	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V14M	NB13	autonomic_ganglia	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.R26H	DSH1	urinary_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.R26H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.R26H	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.R26H	SW954	vulva	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8244
p.R24P	HOS	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8623
p.P20L	KYAE-1	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.P20L	SW962	vulva	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.P20L	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.P20L	LAN-6	autonomic_ganglia	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.P20L	HTC-C3	thyroid	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.H34R	EFM-19	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.H34R	KYSE-140	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.H34R	SK-LU-1	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.H34R	CHL-1	skin	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.R26L	NCI-H847	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8428
p.R26L	NCI-H661	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8428
p.R26L	NCI-H747	large_intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8428
p.R26L	NCI-H441	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8428
p.H34Y	SW13	adrenal_gland	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.A29T	SNU-449	liver	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.A29T	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16L	HCC-44	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.R16L	HOP-92	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.G28R	HPAC	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.V11A	MKN1	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.V11A	HARA	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.T23N	NCI-H524	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7055
p.A27V	MOG-G-CCM	central_nervous_system	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.A27V	CAPAN-1	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.V11M	LOU-NH91	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.V11M	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1111
p.A29D	CAL-62	thyroid	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.A29D	KP-2	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.25
p.Y31C	NCI-H378	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.Y31C	BEN	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.Y31C	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.Y31C	HCC1954	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.Y31C	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.V15G	JHOS-4	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.6667
p.A35S	MFE-319	endometrium	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0833
p.P19H	CAL-39	vulva	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7694
p.K32N	NCI-H650	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1667
p.H20Q	GCIY	stomach	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.H20Q	NCI-H1436	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.H20Q	ES7	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7582
p.G22V	NCI-H446	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7532
p.G22V	SKN-3	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7532
p.G22V	NCI-H2291	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7532
p.A27D	SW1116	large_intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.A27D	HUH-6-clone5	liver	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.3056
p.R22C	REH	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.8301
p.V14L	SKG-IIIa	cervix	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1944
p.C17Y	NCI-H1651	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.D10H	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0833
p.V15D	Caov-4	ovary	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.6667
p.V15D	NCI-H1963	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.6667
p.L35F	T47D	breast	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0833
p.P19S	SCC-4	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.6752
p.P19S	HPAF-II	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.6752
p.C17S	PA-TU-8902	pancreas	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2778
p.R26P	NCI-H2110	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7512
p.P18T	KELLY	autonomic_ganglia	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.75
p.D9N	SNU-1040	large_intestine	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.5
p.R26G	NCI-H2170	lung	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.7568
p.I36T	KYSE-180	oesophagus	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.0556
p.P18L	BICR78	upper_aerodigestive_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.75
p.I30N	647-V	urinary_tract	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.2222
p.K32E	EW-24	bone	COSMIC	FSDLWKLL	DEG_MDM2_SWIB_1	0.1667

Drug responses associated with TP53 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00754	LUAD\|lung_NSCLC_adenocarcinoma	p.V157F (No)	GDSC	MIRA-1	565
SIDM01139	PAAD\|pancreas	p.R248Q (No)	GDSC	MIRA-1	690.98
SIDM00290	STAD\|stomach	p.P153fs*28 (No)	GDSC	MIRA-1	126.26
SIDM00554	UNCLASSIFIED\|ovary	p.D281Y (No)	GDSC	MIRA-1	1072.2
SIDM01194	LIHC\|liver	p.A161T (No)	GDSC	MIRA-1	365.9
SIDM00130	PAAD\|pancreas	p.C242R (No)	GDSC	MIRA-1	601.28
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R248Q (No)	GDSC	MIRA-1	34.36
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.M237I (No)	GDSC	MIRA-1	128.49
SIDM00918	OV\|ovary	p.V147D (No)	GDSC	MIRA-1	535.57
SIDM00402	BLCA\|bladder	p.R248Q (No)	GDSC	MIRA-1	181.31
SIDM00402	BLCA\|bladder	p.S183* (No)	GDSC	MIRA-1	181.31
SIDM00533	PAAD\|pancreas	p.R282W (No)	GDSC	MIRA-1	649.85
SIDM00592	HNSC\|head_and_neck	p.G266R (No)	GDSC	MIRA-1	139.56
SIDM01228	SKCM\|melanoma	p.H193R (No)	GDSC	MIRA-1	180.66
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.Q331* (No)	GDSC	MIRA-1	881.68
SIDM01164	LGG\|glioma	p.R273H (No)	GDSC	MIRA-1	126.81
SIDM01164	LGG\|glioma	p.R273C (No)	GDSC	MIRA-1	126.81
SIDM00935	CESC\|cervix	p.P151H (No)	GDSC	MIRA-1	143.18
SIDM01180	LIHC\|liver	p.K164* (No)	GDSC	MIRA-1	417.85
SIDM00841	COREAD\|large_intestine	p.R273H (No)	GDSC	MIRA-1	2337
SIDM00931	THCA\|thyroid	p.A161D (No)	GDSC	MIRA-1	150.57
SIDM00776	COREAD\|large_intestine	p.R175H (No)	GDSC	MIRA-1	835.49
SIDM01024	ESCA\|oesophagus	p.K120N (No)	GDSC	MIRA-1	809.31
SIDM01031	ESCA\|oesophagus	p.R248Q (No)	GDSC	MIRA-1	179.87
SIDM01188	PAAD\|pancreas	p.G245S (No)	GDSC	MIRA-1	2173.3
SIDM00678	BLCA\|bladder	p.P250L (No)	GDSC	MIRA-1	627.06
SIDM00420	BLCA\|bladder	p.R273C (No)	GDSC	MIRA-1	307.89
SIDM00778	COREAD\|large_intestine	p.R158L (No)	GDSC	MIRA-1	854.41
SIDM01037	BRCA\|breast	p.R248W (No)	GDSC	MIRA-1	265.19
SIDM00358	STAD\|stomach	p.R213* (No)	GDSC	MIRA-1	282.84
SIDM00970	BLCA\|bladder	p.R158H (No)	GDSC	MIRA-1	168.99
SIDM00572	STAD\|stomach	p.Y220C (No)	GDSC	MIRA-1	386.87
SIDM00614	LIHC\|liver	p.R267P (No)	GDSC	MIRA-1	481.47
SIDM00588	HNSC\|head_and_neck	p.R248Q (No)	GDSC	MIRA-1	222.86
SIDM00213	THCA\|thyroid	p.R273H (No)	GDSC	MIRA-1	444.1
SIDM00271	UNCLASSIFIED\|stomach	p.V143A (No)	GDSC	MIRA-1	472.87
SIDM00087	MM\|myeloma	p.E285K (No)	GDSC	MIRA-1	94.354
SIDM00874	BRCA\|breast	p.R306* (No)	GDSC	MIRA-1	661.7
SIDM01135	PAAD\|pancreas	p.I255N (No)	GDSC	MIRA-1	826.14
SIDM00083	LGG\|glioma	p.R342fs*3 (No)	GDSC	MIRA-1	118.48
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R248L (No)	GDSC	MIRA-1	504.01
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R273H (No)	GDSC	MIRA-1	59.401
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.W91* (No)	GDSC	MIRA-1	59.401
SIDM00538	ESCA\|oesophagus	p.R175H (No)	GDSC	MIRA-1	477.76
SIDM00151	OV\|ovary	p.Y126C (No)	GDSC	MIRA-1	254.87
SIDM00499	PRAD\|prostate	p.Q331R (No)	GDSC	MIRA-1	438.14
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.R248P (No)	GDSC	MIRA-1	2.225
SIDM00145	ALL\|lymphoblastic_leukemia	p.R337* (No)	GDSC	MIRA-1	107.19
SIDM00145	ALL\|lymphoblastic_leukemia	p.R306* (No)	GDSC	MIRA-1	107.19
SIDM00967	OV\|ovary	p.R273H (No)	GDSC	MIRA-1	577.48
SIDM01032	ESCA\|oesophagus	p.H193R (No)	GDSC	MIRA-1	213
SIDM00455	PAAD\|pancreas	p.C176S (No)	GDSC	MIRA-1	966.22
SIDM00724	LUAD\|lung_NSCLC_adenocarcinoma	p.R273H (No)	GDSC	MIRA-1	3401.2
SIDM00121	ALL\|lymphoblastic_leukemia	p.R248Q (No)	GDSC	MIRA-1	62.852
SIDM00121	ALL\|lymphoblastic_leukemia	p.R175H (No)	GDSC	MIRA-1	62.852
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.L35fs*9 (Yes)	GDSC	MIRA-1	110.42
SIDM00550	ESCA\|oesophagus	p.K101* (No)	GDSC	MIRA-1	244.08
SIDM00997	THCA\|thyroid	p.R273C (No)	GDSC	MIRA-1	282.2
SIDM00901	UCEC\|endometrium	p.R213Q (No)	GDSC	MIRA-1	65.639
SIDM00351	HNSC\|head_and_neck	p.E336* (No)	GDSC	MIRA-1	60.58
SIDM00849	KIRC\|kidney	p.E258* (No)	GDSC	MIRA-1	229.01
SIDM00849	KIRC\|kidney	p.C135R (No)	GDSC	MIRA-1	229.01
SIDM00849	KIRC\|kidney	p.Y126D (No)	GDSC	MIRA-1	229.01
SIDM00334	UCEC\|endometrium	p.R306* (No)	GDSC	MIRA-1	484.4
SIDM00334	UCEC\|endometrium	p.Y220C (No)	GDSC	MIRA-1	484.4
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.P47fs*76 (No)	GDSC	MIRA-1	227.46
SIDM00260	STAD\|stomach	p.I251L (No)	GDSC	MIRA-1	451.45
SIDM00831	HNSC\|head_and_neck	p.R175H (No)	GDSC	MIRA-1	167.88
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.G245V (No)	GDSC	MIRA-1	22.559
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.P191fs*56 (No)	GDSC	MIRA-1	269.96
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.R273H (No)	GDSC	MIRA-1	166.64
SIDM00937	HNSC\|head_and_neck	p.H193L (No)	GDSC	MIRA-1	231.66
SIDM00353	UNCLASSIFIED\|ovary	p.R175H (No)	GDSC	MIRA-1	696.06
SIDM00196	UNCLASSIFIED\|ewings_sarcoma	p.R175H (No)	GDSC	MIRA-1	152.18
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.M246I (No)	GDSC	MIRA-1	220.58
SIDM00252	UNCLASSIFIED\|biliary_tract	p.C176fs*6 (No)	GDSC	MIRA-1	354.16
SIDM00797	SKCM\|melanoma	p.V274F (No)	GDSC	MIRA-1	103.26
SIDM00453	PAAD\|pancreas	p.R282W (No)	GDSC	MIRA-1	437.54
SIDM00214	COREAD\|large_intestine	p.S90fs*33 (No)	GDSC	MIRA-1	289.9
SIDM00976	SKCM\|melanoma	p.R248Q (No)	GDSC	MIRA-1	155.6
SIDM00956	ESCA\|oesophagus	p.R248W (No)	GDSC	MIRA-1	909.12
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.R248Q (No)	GDSC	MIRA-1	3.0672
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.R248Q (No)	GDSC	MIRA-1	59.71
SIDM00350	HNSC\|head_and_neck	p.E271* (No)	GDSC	MIRA-1	390.63
SIDM00350	HNSC\|head_and_neck	p.R110L (No)	GDSC	MIRA-1	390.63
SIDM00045	STAD\|stomach	p.G245S (No)	GDSC	MIRA-1	56.032
SIDM01048	MM\|lymphoid_neoplasm_other	p.K132N (No)	GDSC	MIRA-1	105.3
SIDM00250	ESCA\|oesophagus	p.G245C (No)	GDSC	MIRA-1	163.51
SIDM00267	UNCLASSIFIED\|biliary_tract	p.C242fs*5 (No)	GDSC	MIRA-1	486.44
SIDM00199	UNCLASSIFIED\|bone_other	p.G245D (No)	GDSC	MIRA-1	199.8
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.C176W (No)	GDSC	MIRA-1	89.12
SIDM00669	PAAD\|pancreas	p.P151S (No)	GDSC	MIRA-1	781.36
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R273H (No)	GDSC	MIRA-1	209.76
SIDM01007	ALL\|lymphoblastic_leukemia	p.R273C (No)	GDSC	MIRA-1	82.935
SIDM01007	ALL\|lymphoblastic_leukemia	p.R175H (No)	GDSC	MIRA-1	82.935
SIDM00781	COREAD\|large_intestine	p.R273H (No)	GDSC	MIRA-1	3509.2
SIDM00781	COREAD\|large_intestine	p.R273C (No)	GDSC	MIRA-1	3509.2
SIDM00391	MM\|myeloma	p.K132N (No)	GDSC	MIRA-1	157.96
SIDM00146	BRCA\|breast	p.R280K (No)	GDSC	MIRA-1	121.9
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.K132R (No)	GDSC	MIRA-1	17.497
SIDM00326	ESCA\|oesophagus	p.M237I (No)	GDSC	MIRA-1	217.3
SIDM01229	NB\|neuroblastoma	p.C135F (No)	GDSC	MIRA-1	311.84
SIDM00381	CESC\|cervix	p.R273H (No)	GDSC	MIRA-1	290.38
SIDM00381	CESC\|cervix	p.K132N (No)	GDSC	MIRA-1	290.38
SIDM00088	PRAD\|prostate	p.K139fs*31 (No)	GDSC	MIRA-1	844.28
SIDM01190	BLCA\|bladder	p.E349* (No)	GDSC	MIRA-1	638.61
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V143M (No)	GDSC	MIRA-1	563.51
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.R273H (No)	GDSC	MIRA-1	1699.5
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.R209* (No)	GDSC	MIRA-1	1699.5
SIDM00393	STAD\|stomach	p.R175H (No)	GDSC	MIRA-1	195.89
SIDM01056	BRCA\|breast	p.H193R (No)	GDSC	MIRA-1	187.59
SIDM00565	HNSC\|head_and_neck	p.R249S (No)	GDSC	MIRA-1	543.37
SIDM01009	NB\|neuroblastoma	p.P177T (No)	GDSC	MIRA-1	91.967
SIDM00100	MESO\|mesothelioma	p.R273C (No)	GDSC	MIRA-1	879.07
SIDM00936	BLCA\|bladder	p.R282W (No)	GDSC	MIRA-1	275.88
SIDM00686	UCEC\|endometrium	p.R175H (No)	GDSC	MIRA-1	1104
SIDM00466	OV\|ovary	p.R282W (No)	GDSC	MIRA-1	3815
SIDM01132	MB\|medulloblastoma	p.C275G (No)	GDSC	MIRA-1	158.5
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.C135F (No)	GDSC	MIRA-1	101.75
SIDM00212	GBM\|glioma	p.R248W (No)	GDSC	MIRA-1	631.04
SIDM00251	STAD\|stomach	p.R273C (No)	GDSC	MIRA-1	212.8
SIDM00499	PRAD\|prostate	p.V73fs*50 (No)	GDSC	MIRA-1	438.14
SIDM00814	ACC\|adrenal_gland	p.H193Y (No)	GDSC	MIRA-1	107.53
SIDM00085	GBM\|glioma	p.R273H (No)	GDSC	MIRA-1	407.73
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R248Q (No)	GDSC	MIRA-1	41.671
SIDM00732	GBM\|glioma	p.R175H (No)	GDSC	MIRA-1	108.31
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.R175H (No)	GDSC	MIRA-1	155.59
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.Y234H (No)	GDSC	MIRA-1	54.855
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.R213Q (No)	GDSC	MIRA-1	54.855
SIDM00220	OV\|ovary	p.R273H (No)	GDSC	MIRA-1	177.8
SIDM01030	ESCA\|oesophagus	p.I195T (No)	GDSC	MIRA-1	209.03
SIDM00938	BRCA\|breast	p.E224K (No)	GDSC	MIRA-1	65.804
SIDM00655	\|testis	p.V272fs*73 (No)	GDSC	MIRA-1	71.548
SIDM01099	NB\|neuroblastoma	p.M246R (No)	GDSC	MIRA-1	174.94
SIDM00003	SKCM\|melanoma	p.G266E (No)	GDSC	MIRA-1	314.33
SIDM00901	UCEC\|endometrium	p.S90fs*33 (No)	GDSC	MIRA-1	65.639
SIDM00444	ESCA\|oesophagus	p.T55fs*68 (No)	GDSC	MIRA-1	163.57
SIDM00675	BRCA\|breast	p.R273L (No)	GDSC	MIRA-1	220.46
SIDM00998	GBM\|glioma	p.R273C (No)	GDSC	MIRA-1	144.74
SIDM00377	UNCLASSIFIED\|uterus	p.C242F (No)	GDSC	MIRA-1	322.42
SIDM00887	MB\|medulloblastoma	p.C242F (No)	GDSC	MIRA-1	158.19
SIDM00875	UNCLASSIFIED\|breast	p.T256fs*90 (No)	GDSC	MIRA-1	138.85
SIDM00586	LIHC\|liver	p.R110L (No)	GDSC	MIRA-1	693.08
SIDM00498	COREAD\|large_intestine	p.R248W (No)	GDSC	MIRA-1	396.32
SIDM00551	ESCA\|oesophagus	p.R248W (No)	GDSC	MIRA-1	102.18
SIDM00483	ESCA\|oesophagus	p.Q100* (No)	GDSC	MIRA-1	1471.3
SIDM01043	UNCLASSIFIED\|endometrium	p.R213* (No)	GDSC	MIRA-1	129.52
SIDM00629	BRCA\|breast	p.E204fs*7 (No)	GDSC	MIRA-1	435.56
SIDM01168	OV\|ovary	p.G262V (No)	GDSC	MIRA-1	976.06
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.V272L (No)	GDSC	MIRA-1	73.428
SIDM01129	SCLC\|lung_small_cell_carcinoma	p.T155N (No)	GDSC	MIRA-1	78.288
SIDM01197	COREAD\|large_intestine	p.S166* (No)	GDSC	MIRA-1	441.04
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.R248Q (No)	GDSC	MIRA-1	9.33
SIDM00612	LGG\|glioma	p.R248Q (No)	GDSC	MIRA-1	759.24
SIDM00612	LGG\|glioma	p.G245S (No)	GDSC	MIRA-1	759.24
SIDM00151	OV\|ovary	p.S90fs*59 (No)	GDSC	MIRA-1	254.87
SIDM00982	GBM\|glioma	p.R282Q (No)	GDSC	MIRA-1	241.93
SIDM00316	GBM\|glioma	p.F113V (No)	GDSC	MIRA-1	188.46
SIDM00553	LAML\|leukemia	p.R175H (No)	GDSC	MIRA-1	8.9244
SIDM00418	THCA\|thyroid	p.R273C (No)	GDSC	MIRA-1	1836.1
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.R273L (No)	GDSC	MIRA-1	190.25
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.V157F (No)	GDSC	MIRA-1	833.08
SIDM00988	KIRC\|kidney	p.S241C (No)	GDSC	MIRA-1	191.31
SIDM00988	KIRC\|kidney	p.E224* (No)	GDSC	MIRA-1	191.31
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R158H (No)	GDSC	MIRA-1	7.5992
SIDM00488	COREAD\|large_intestine	p.V272M (No)	GDSC	MIRA-1	184.78
SIDM00194	COREAD\|large_intestine	p.R175H (No)	GDSC	MIRA-1	628.67
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R213Q (No)	GDSC	MIRA-1	6.8249
SIDM00774	BRCA\|breast	p.R248W (No)	GDSC	MIRA-1	48.411
SIDM00504	LGG\|glioma	p.R110P (No)	GDSC	MIRA-1	140.8
SIDM00411	PAAD\|pancreas	p.H179R (No)	GDSC	MIRA-1	659.84
SIDM01077	PRAD\|prostate	p.R248W (No)	GDSC	MIRA-1	308.09
SIDM01020	MM\|myeloma	p.R337L (No)	GDSC	MIRA-1	26.978
SIDM00347	ESCA\|oesophagus	p.V272L (No)	GDSC	MIRA-1	362.04
SIDM00716	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R158G (No)	GDSC	MIRA-1	266.55
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.G154V (No)	GDSC	MIRA-1	208.34
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.Y163C (No)	GDSC	MIRA-1	41.359
SIDM00505	PAAD\|pancreas	p.R248W (No)	GDSC	MIRA-1	147
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.G244C (No)	GDSC	MIRA-1	44.616
SIDM00156	NB\|neuroblastoma	p.P278L (No)	GDSC	MIRA-1	217.36
SIDM00156	NB\|neuroblastoma	p.G262S (No)	GDSC	MIRA-1	217.36
SIDM00251	STAD\|stomach	p.K382fs*40 (No)	GDSC	MIRA-1	212.8
SIDM00792	SCLC\|lung_small_cell_carcinoma	p.Q192* (No)	GDSC	MIRA-1	189.53
SIDM00506	SCLC\|lung_small_cell_carcinoma	p.V157F (No)	GDSC	MIRA-1	45.658
SIDM00833	COREAD\|large_intestine	p.R248W (No)	GDSC	MIRA-1	468.07
SIDM01045	UCEC\|endometrium	p.R273H (No)	GDSC	MIRA-1	217.79
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.R273L (No)	GDSC	MIRA-1	1208.1
SIDM01028	ESCA\|oesophagus	p.R337C (No)	GDSC	MIRA-1	986.94
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.E171* (No)	GDSC	MIRA-1	102.01
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E171* (No)	GDSC	MIRA-1	447.25
SIDM00532	LGG\|glioma	p.A159V (No)	GDSC	MIRA-1	732.31
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S215I (No)	GDSC	MIRA-1	532.45
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R158L (No)	GDSC	MIRA-1	532.45
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.E285V (No)	GDSC	MIRA-1	263.66
SIDM00872	BRCA\|breast	p.Y163C (No)	GDSC	MIRA-1	264.85
SIDM00946	ALL\|T_cell_leukemia	p.R248Q (No)	GDSC	MIRA-1	70.626
SIDM01019	LAML\|acute_myeloid_leukaemia	p.V272M (No)	GDSC	MIRA-1	89.165
SIDM00369	ESCA\|oesophagus	p.V272M (No)	GDSC	MIRA-1	388.65
SIDM00325	ESCA\|oesophagus	p.N268fs*77 (No)	GDSC	MIRA-1	183.92
SIDM00568	STAD\|stomach	p.V31I (Yes)	GDSC	MIRA-1	353.07
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.Q317* (No)	GDSC	MIRA-1	348.92
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.R248W (No)	GDSC	MIRA-1	348.92
SIDM01165	PAAD\|pancreas	p.P191delP (No)	GDSC	MIRA-1	433.66
SIDM00211	ALL\|lymphoblastic_leukemia	p.R248Q (No)	GDSC	MIRA-1	40.742
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.R248L (No)	GDSC	MIRA-1	485.74
SIDM00882	BRCA\|breast	p.A74fs*47 (No)	GDSC	MIRA-1	200.72
SIDM00042	PAAD\|pancreas	p.G266V (No)	GDSC	MIRA-1	451.93
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.Q136fs*13 (No)	GDSC	MIRA-1	217.41
SIDM00333	UCEC\|endometrium	p.R273C (No)	GDSC	MIRA-1	249.98
SIDM00333	UCEC\|endometrium	p.Y220C (No)	GDSC	MIRA-1	249.98
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V143A (No)	GDSC	MIRA-1	126.02
SIDM01193	GBM\|glioma	p.R213Q (No)	GDSC	MIRA-1	547.42
SIDM00122	BRCA\|breast	p.R249S (No)	GDSC	MIRA-1	511.32
SIDM00530	ESCA\|oesophagus	p.P152L (No)	GDSC	MIRA-1	265.9
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.I232N (No)	GDSC	MIRA-1	6.1184
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.P152L (No)	GDSC	MIRA-1	6.1184
SIDM00667	UNCLASSIFIED\|fibrosarcoma	p.E285fs*60 (No)	GDSC	MIRA-1	127.98
SIDM00630	BRCA\|breast	p.Y236C (No)	GDSC	MIRA-1	69.84
SIDM00489	HNSC\|head_and_neck	p.R248W (No)	GDSC	MIRA-1	185.6
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.R283P (No)	GDSC	MIRA-1	57.604
SIDM00044	HNSC\|head_and_neck	p.P153fs*28 (No)	GDSC	MIRA-1	434.72
SIDM01155	GBM\|glioma	p.R273C (No)	GDSC	MIRA-1	304.2
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.C277F (No)	GDSC	MIRA-1	686.09
SIDM00796	UNCLASSIFIED\|head_and_neck	p.E180fs*67 (No)	GDSC	MIRA-1	168.76
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.S241F (No)	GDSC	MIRA-1	500.17
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.E56* (No)	GDSC	MIRA-1	500.17
SIDM00999	BLCA\|bladder	p.R248Q (No)	GDSC	MIRA-1	198.51
SIDM00079	OV\|ovary	p.S90fs*33 (No)	GDSC	MIRA-1	1082.5
SIDM00287	UNCLASSIFIED\|B_cell_leukemia	p.D281G (No)	GDSC	MIRA-1	9.2198
SIDM00893	BRCA\|breast	p.K132Q (No)	GDSC	MIRA-1	147.27
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.L35fs*8 (Yes)	GDSC	MIRA-1	243
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R175L (No)	GDSC	MIRA-1	641.28
SIDM00807	BLCA\|bladder	p.R280T (No)	GDSC	MIRA-1	385.04
SIDM00478	ESCA\|oesophagus	p.S90fs*33 (No)	GDSC	MIRA-1	330.71
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.R175L (No)	GDSC	MIRA-1	234.59
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.S94* (No)	GDSC	MIRA-1	234.59
SIDM00094	KIRC\|kidney	p.E336* (No)	GDSC	MIRA-1	436.3
SIDM00681	COREAD\|large_intestine	p.G245S (No)	GDSC	MIRA-1	227.22
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.R283H (No)	GDSC	MIRA-1	194.29
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G245S (No)	GDSC	MIRA-1	194.29
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.C176W (No)	GDSC	MIRA-1	243.34
SIDM00323	DLBC\|B_cell_lymphoma	p.E180* (No)	GDSC	MIRA-1	103.51
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.R273C (No)	GDSC	MIRA-1	6.1438
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.A76fs*73 (No)	GDSC	MIRA-1	492.2
SIDM00082	SKCM\|melanoma	p.G245S (No)	GDSC	MIRA-1	72.124
SIDM00889	CESC\|cervix	p.R273C (No)	GDSC	MIRA-1	223.45
SIDM00898	BRCA\|breast	p.R175H (No)	GDSC	MIRA-1	213.68
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.R248Q (No)	GDSC	MIRA-1	98.361
SIDM01042	BRCA\|breast	p.S241C (No)	GDSC	MIRA-1	101.12
SIDM00049	COREAD\|large_intestine	p.K132R (No)	GDSC	MIRA-1	288.92
SIDM00665	STAD\|stomach	p.K319* (No)	GDSC	MIRA-1	512.24
SIDM01141	OV\|ovary	p.S215R (No)	GDSC	MIRA-1	529.32
SIDM00276	UNCLASSIFIED\|biliary_tract	p.R175H (No)	GDSC	MIRA-1	316.83
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M237I (No)	GDSC	MIRA-1	173.54
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.I254N (No)	GDSC	MIRA-1	40.566
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.I254V (No)	GDSC	MIRA-1	40.566
SIDM00571	UNCLASSIFIED\|pancreas	p.P153fs*28 (No)	GDSC	MIRA-1	566.24
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.C242W (No)	GDSC	MIRA-1	288.33
SIDM00111	GBM\|glioma	p.R273H (No)	GDSC	MIRA-1	497.64
SIDM00477	ESCA\|oesophagus	p.C135Y (No)	GDSC	MIRA-1	347.66
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.N239D (No)	GDSC	MIRA-1	24.456
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.R158H (No)	GDSC	MIRA-1	24.456
SIDM00596	UCEC\|endometrium	p.R248Q (No)	GDSC	MIRA-1	484.38
SIDM00274	STAD\|stomach	p.H179Q (No)	GDSC	MIRA-1	416.45
SIDM00114	MESO\|mesothelioma	p.N239fs*25 (No)	GDSC	MIRA-1	502.69
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.C242S (No)	GDSC	MIRA-1	196.93
SIDM00613	LGG\|glioma	p.S241F (No)	GDSC	MIRA-1	216.42
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.R273C (No)	GDSC	MIRA-1	140.01
SIDM00529	BRCA\|breast	p.A88fs*52 (No)	GDSC	MIRA-1	224.07
SIDM01006	MM\|haematopoietic_neoplasm_other	p.C135Y (No)	GDSC	MIRA-1	77.984
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.R209* (No)	GDSC	MIRA-1	393.7
SIDM01088	UNCLASSIFIED\|endometrium	p.V73fs*50 (No)	GDSC	MIRA-1	203.54
SIDM01159	UNCLASSIFIED\|soft_tissue_other	p.I251N (No)	GDSC	MIRA-1	430.64
SIDM00842	COREAD\|large_intestine	p.R248W (No)	GDSC	MIRA-1	115.84
SIDM00363	LAML\|acute_myeloid_leukaemia	p.Y236C (No)	GDSC	MIRA-1	82.462
SIDM00363	LAML\|acute_myeloid_leukaemia	p.R196* (No)	GDSC	MIRA-1	82.462
SIDM00150	COREAD\|large_intestine	p.H179R (No)	GDSC	MIRA-1	263.63
SIDM01024	ESCA\|oesophagus	p.I251fs*13 (No)	GDSC	MIRA-1	809.31
SIDM00469	PAAD\|pancreas	p.K132Q (No)	GDSC	MIRA-1	301.26
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.R273L (No)	GDSC	MIRA-1	194.38
SIDM00660	COREAD\|large_intestine	p.Y126* (No)	GDSC	MIRA-1	317.27
SIDM00182	HNSC\|head_and_neck	p.H179R (No)	GDSC	MIRA-1	616.39
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.G245C (No)	GDSC	MIRA-1	155.92
SIDM00922	LUAD\|lung_NSCLC_adenocarcinoma	p.M237I (No)	GDSC	MIRA-1	470.5
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.H214R (No)	GDSC	MIRA-1	127.51
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.V147D (No)	GDSC	MIRA-1	127.51
SIDM01066	SKCM\|melanoma	p.C229fs*10 (No)	GDSC	MIRA-1	111.77
SIDM00928	BRCA\|breast	p.K132E (No)	GDSC	MIRA-1	190.43
SIDM01137	PAAD\|pancreas	p.G245S (No)	GDSC	MIRA-1	4997.8
SIDM00589	HNSC\|head_and_neck	p.R306fs*1 (No)	GDSC	MIRA-1	217.41
SIDM00197	UNCLASSIFIED\|ewings_sarcoma	p.C176F (No)	GDSC	MIRA-1	147.24
SIDM01100	NB\|neuroblastoma	p.R110L (No)	GDSC	MIRA-1	236.3
SIDM00321	UNCLASSIFIED\|ovary	p.R175H (No)	GDSC	MIRA-1	625.15
SIDM00587	UNCLASSIFIED\|biliary_tract	p.R175H (No)	GDSC	MIRA-1	305.76
SIDM00763	UNCLASSIFIED\|lung_NSCLC_large_cell	p.K291* (No)	GDSC	MIRA-1	585.34
SIDM00882	BRCA\|breast	p.Y220C (No)	GDSC	MIRA-1	200.72
SIDM00886	DLBC\|B_cell_lymphoma	p.R248Q (No)	GDSC	MIRA-1	97.405
SIDM00886	DLBC\|B_cell_lymphoma	p.R248W (No)	GDSC	MIRA-1	97.405
SIDM01147	STAD\|stomach	p.R248Q (No)	GDSC	MIRA-1	476.56
SIDM00847	UNCLASSIFIED\|rhabdomyosarcoma	p.R248W (No)	GDSC	MIRA-1	175.82
SIDM01050	UNCLASSIFIED\|biliary_tract	p.R273H (No)	GDSC	MIRA-1	1259.5
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.R158L (No)	GDSC	MIRA-1	6233
SIDM00673	BRCA\|breast	p.R248Q (No)	GDSC	MIRA-1	107.73
SIDM00501	HNSC\|head_and_neck	p.P177L (No)	GDSC	MIRA-1	591.05
SIDM00501	HNSC\|head_and_neck	p.C176F (No)	GDSC	MIRA-1	591.05
SIDM00501	HNSC\|head_and_neck	p.Q38* (No)	GDSC	MIRA-1	591.05
SIDM00097	BRCA\|breast	p.L194F (No)	GDSC	MIRA-1	393.63
SIDM00359	COREAD\|large_intestine	p.R306* (No)	GDSC	MIRA-1	666.02
SIDM01145	STAD\|stomach	p.Y205F (No)	GDSC	MIRA-1	71.092
SIDM01245	ALL\|lymphoblastic_leukemia	p.Y163C (No)	GDSC	MIRA-1	112.82
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.K120fs*3 (No)	GDSC	MIRA-1	286.93
SIDM00580	LAML\|acute_myeloid_leukaemia	p.C242fs*5 (No)	GDSC	MIRA-1	83.745
SIDM00379	GBM\|glioma	p.F113C (No)	GDSC	MIRA-1	345.9
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.R196* (No)	GDSC	MIRA-1	8.4258
SIDM00247	STAD\|stomach	p.R110C (No)	GDSC	MIRA-1	345.78
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R273L (No)	GDSC	MIRA-1	564.79
SIDM00996	THCA\|thyroid	p.R248G (No)	GDSC	MIRA-1	586.64
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.G266E (No)	GDSC	MIRA-1	77.326
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.S240R (No)	GDSC	MIRA-1	207.29
SIDM00322	ESCA\|oesophagus	p.E258* (No)	GDSC	MIRA-1	150.13
SIDM00322	ESCA\|oesophagus	p.H214R (No)	GDSC	MIRA-1	150.13
SIDM00475	OV\|ovary	p.K101fs*47 (No)	GDSC	MIRA-1	689.31
SIDM00125	KIRC\|kidney	p.P278A (No)	GDSC	MIRA-1	177.72
SIDM00375	HNSC\|head_and_neck	p.G154V (No)	GDSC	MIRA-1	305.02
SIDM00375	HNSC\|head_and_neck	p.S106R (No)	GDSC	MIRA-1	305.02
SIDM00987	THCA\|thyroid	p.I251T (No)	GDSC	MIRA-1	214.49
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.H179Q (No)	GDSC	MIRA-1	39.393
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.R280S (No)	GDSC	MIRA-1	160.29
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.R273C (No)	GDSC	MIRA-1	160.29
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.Y205C (No)	GDSC	MIRA-1	160.29
SIDM00458	LAML\|acute_myeloid_leukaemia	p.L145R (No)	GDSC	MIRA-1	38.98
SIDM00257	NB\|neuroblastoma	p.V173M (No)	GDSC	MIRA-1	63.734
SIDM00479	ESCA\|oesophagus	p.N310fs*27 (No)	GDSC	MIRA-1	421.31
SIDM00150	COREAD\|large_intestine	p.V73fs*50 (No)	GDSC	MIRA-1	263.63
SIDM00517	UNCLASSIFIED\|head_and_neck	p.R213* (No)	GDSC	MIRA-1	273.5
SIDM00413	DLBC\|B_cell_lymphoma	p.R248Q (No)	GDSC	MIRA-1	78.566
SIDM00132	PAAD\|pancreas	p.Y220C (No)	GDSC	MIRA-1	315.34
SIDM00866	BRCA\|breast	p.R248Q (No)	GDSC	MIRA-1	943.67
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G245C (No)	GDSC	MIRA-1	155.35
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.Y220C (No)	GDSC	MIRA-1	91.43
SIDM00658	LUAD\|lung_NSCLC_adenocarcinoma	p.C141W (No)	GDSC	MIRA-1	151.29
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.G244D (No)	GDSC	MIRA-1	145.56
SIDM00789	COREAD\|large_intestine	p.S241F (No)	GDSC	MIRA-1	279.95
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.R213* (No)	GDSC	MIRA-1	761.95
SIDM00273	LGG\|glioma	p.C275Y (No)	GDSC	MIRA-1	142.1
SIDM01080	HNSC\|head_and_neck	p.C275fs*20 (No)	GDSC	MIRA-1	255.81
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Q167* (No)	GDSC	MIRA-1	623.77
SIDM00371	PAAD\|pancreas	p.R273H (No)	GDSC	MIRA-1	1532.4
SIDM00487	COREAD\|large_intestine	p.P278H (No)	GDSC	MIRA-1	115.04
SIDM00861	UNCLASSIFIED\|ovary	p.S241F (No)	GDSC	MIRA-1	370
SIDM00642	SCLC\|lung_small_cell_carcinoma	p.R175fs*72 (No)	GDSC	MIRA-1	211.98
SIDM00591	HNSC\|head_and_neck	p.G293fs*13 (No)	GDSC	MIRA-1	198.32
SIDM00414	BLCA\|bladder	p.R175H (No)	GDSC	MIRA-1	206.64
SIDM01041	ESCA\|oesophagus	p.C277F (No)	GDSC	MIRA-1	197.69
SIDM00963	BRCA\|breast	p.E285K (No)	GDSC	MIRA-1	773.72
SIDM00583	PAAD\|pancreas	p.R273H (No)	GDSC	MIRA-1	419.46
SIDM01008	DLBC\|B_cell_lymphoma	p.K319* (No)	GDSC	MIRA-1	143.45
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.R248L (No)	GDSC	MIRA-1	138.94
SIDM00136	COREAD\|large_intestine	p.R273H (No)	GDSC	MIRA-1	1259
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.G244S (No)	GDSC	MIRA-1	93.039
SIDM00585	LIHC\|liver	p.Y220C (No)	GDSC	MIRA-1	518.98
SIDM01003	ALL\|lymphoblastic_leukemia	p.P153fs*28 (No)	GDSC	MIRA-1	59.62
SIDM00485	HNSC\|head_and_neck	p.F109fs*37 (No)	GDSC	MIRA-1	133.28
SIDM00582	PAAD\|pancreas	p.A161D (No)	GDSC	MIRA-1	532.38
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.V272M (No)	GDSC	MIRA-1	18.285
SIDM00502	DLBC\|B_cell_lymphoma	p.R249G (No)	GDSC	MIRA-1	78.042
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E294* (No)	GDSC	MIRA-1	186.33
SIDM00092	OV\|ovary	p.L130V (No)	GDSC	MIRA-1	553.67
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.G245C (No)	GDSC	MIRA-1	392.63
SIDM00343	GBM\|glioma	p.R282W (No)	GDSC	MIRA-1	553.45
SIDM00628	BRCA\|breast	p.R273H (No)	GDSC	MIRA-1	150.76
SIDM00748	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q144* (No)	GDSC	MIRA-1	121.78
SIDM00545	SKCM\|melanoma	p.Q317* (No)	GDSC	MIRA-1	382.68
SIDM00545	SKCM\|melanoma	p.E258K (No)	GDSC	MIRA-1	382.68
SIDM00127	HNSC\|head_and_neck	p.S99fs*24 (No)	GDSC	MIRA-1	779.44
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y107* (No)	GDSC	MIRA-1	300.71
SIDM01183	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.D228fs*19 (No)	GDSC	MIRA-1	317.65
SIDM00120	PRAD\|prostate	p.V274F (No)	GDSC	MIRA-1	370.68
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y220C (No)	GDSC	MIRA-1	400.85
SIDM00560	STAD\|stomach	p.P278S (No)	GDSC	MIRA-1	764.79
SIDM00181	BLCA\|bladder	p.S241Y (No)	GDSC	MIRA-1	181.53
SIDM00407	DLBC\|B_cell_lymphoma	p.Y234C (No)	GDSC	MIRA-1	29.583
SIDM00241	BRCA\|breast	p.G244S (No)	GDSC	MIRA-1	67.596
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.V157F (No)	GDSC	MIRA-1	399.34
SIDM00541	COREAD\|large_intestine	p.R213L (No)	GDSC	MIRA-1	349.4
SIDM00616	LIHC\|liver	p.R249S (No)	GDSC	MIRA-1	530.48
SIDM00328	ESCA\|oesophagus	p.R248Q (No)	GDSC	MIRA-1	421.5
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R273H (No)	GDSC	MIRA-1	28.889
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R267L (No)	GDSC	MIRA-1	28.889
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R248Q (No)	GDSC	MIRA-1	28.889
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S215C (No)	GDSC	MIRA-1	2.8118
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.V272M (No)	GDSC	MIRA-1	222.33
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.C242F (No)	GDSC	MIRA-1	247.7
SIDM01233	COREAD\|large_intestine	p.E204* (No)	GDSC	MIRA-1	808.32
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.R248Q (No)	GDSC	MIRA-1	28.543
SIDM00934	PAAD\|pancreas	p.A159V (No)	GDSC	MIRA-1	513.96
SIDM00528	BRCA\|breast	p.E56* (No)	GDSC	MIRA-1	192.77
SIDM00225	SKCM\|melanoma	p.R248W (No)	GDSC	MIRA-1	232.68
SIDM00225	SKCM\|melanoma	p.N247K (No)	GDSC	MIRA-1	232.68
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.H179R (No)	GDSC	MIRA-1	2432.7
SIDM00992	THCA\|thyroid	p.D259Y (No)	GDSC	MIRA-1	460.65
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.D259V (No)	GDSC	MIRA-1	455.63
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.E298* (No)	GDSC	MIRA-1	380.5
SIDM01151	LIHC\|liver	p.S215I (No)	GDSC	MIRA-1	678.53
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R273H (No)	GDSC	MIRA-1	5.43
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R273C (No)	GDSC	MIRA-1	5.43
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.R248Q (No)	GDSC	MIRA-1	5.43
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.R273H (No)	GDSC	MIRA-1	392.81
SIDM00445	ESCA\|oesophagus	p.Q192* (No)	GDSC	MIRA-1	200.61
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.E285K (No)	GDSC	MIRA-1	557.99
SIDM00779	COREAD\|large_intestine	p.E224D (No)	GDSC	MIRA-1	368.24
SIDM01171	GBM\|glioma	p.M237I (No)	GDSC	MIRA-1	156.5
SIDM00064	LIHC\|liver	p.G244A (No)	GDSC	MIRA-1	138.75
SIDM00960	COREAD\|large_intestine	p.R248Q (No)	GDSC	MIRA-1	319.22
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.C176F (No)	GDSC	MIRA-1	124.08
SIDM01023	LAML\|acute_myeloid_leukaemia	p.R273H (No)	GDSC	MIRA-1	68.365
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R248Q (No)	GDSC	MIRA-1	229.08
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R175H (No)	GDSC	MIRA-1	229.08
SIDM00865	SCLC\|lung_small_cell_carcinoma	p.R213* (No)	GDSC	MIRA-1	147.56
SIDM00503	STAD\|stomach	p.Y220D (No)	GDSC	MIRA-1	158.2
SIDM00417	MM\|myeloma	p.A161T (No)	GDSC	MIRA-1	23.477
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.H193R (No)	GDSC	MIRA-1	477.41
SIDM01182	BLCA\|bladder	p.F113C (No)	GDSC	MIRA-1	118.24
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.C176F (No)	GDSC	MIRA-1	63.878
SIDM00354	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S37fs*70 (Yes)	GDSC	MIRA-1	293.02
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.R248W (No)	GDSC	MIRA-1	126.06
SIDM00561	UNCLASSIFIED\|hairy_cell_leukaemia	p.R280G (No)	GDSC	MIRA-1	30.62
SIDM01111	UNCLASSIFIED\|ewings_sarcoma	p.C176F (No)	GDSC	MIRA-1	65.61
SIDM00346	LCML\|chronic_myeloid_leukaemia	p.K319* (No)	GDSC	MIRA-1	74.042
SIDM00491	THCA\|thyroid	p.H179R (No)	GDSC	MIRA-1	215.71
SIDM00444	ESCA\|oesophagus	p.R248Q (No)	GDSC	MIRA-1	163.57
SIDM00481	OV\|ovary	p.P152fs*18 (No)	GDSC	MIRA-1	594.51
SIDM00306	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q192* (No)	GDSC	MIRA-1	292.5
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.R175H (No)	GDSC	MIRA-1	644.67
SIDM00899	PAAD\|pancreas	p.C135fs*35 (No)	GDSC	MIRA-1	3082.7
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.R156P (No)	GDSC	MIRA-1	117.38
SIDM00606	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R249S (No)	GDSC	MIRA-1	241.73
SIDM00921	LUAD\|lung_NSCLC_adenocarcinoma	p.R196* (No)	GDSC	MIRA-1	494.03
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.R213* (No)	GDSC	MIRA-1	107.75
SIDM01081	HNSC\|head_and_neck	p.P151S (No)	GDSC	MIRA-1	200.87
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.W146* (No)	GDSC	MIRA-1	402.79
SIDM00539	ESCA\|oesophagus	p.R248W (No)	GDSC	MIRA-1	250.41
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.C176Y (No)	GDSC	MIRA-1	197.18
SIDM00983	BLCA\|bladder	p.E336* (No)	GDSC	MIRA-1	261.85
SIDM00983	BLCA\|bladder	p.I162N (No)	GDSC	MIRA-1	261.85
SIDM00203	UNCLASSIFIED\|ewings_sarcoma	p.R273C (No)	GDSC	MIRA-1	217.16
SIDM00834	COREAD\|large_intestine	p.R248Q (No)	GDSC	MIRA-1	187.95
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R273C (No)	GDSC	MIRA-1	227.46
SIDM00135	BRCA\|breast	p.V157F (No)	GDSC	MIRA-1	159.47
SIDM00884	BRCA\|breast	p.R175H (No)	GDSC	MIRA-1	253.07
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.E294* (No)	GDSC	MIRA-1	199.42
SIDM00942	HNSC\|head_and_neck	p.R175H (No)	GDSC	MIRA-1	242.38
SIDM01170	OV\|ovary	p.R175H (No)	GDSC	MIRA-1	178.08
SIDM01259	ALL\|lymphoblastic_leukemia	p.M246T (No)	GDSC	MIRA-1	174.64
SIDM01002	BRCA\|breast	p.E271fs*1 (No)	GDSC	MIRA-1	383.85
SIDM00709	LUAD\|lung_NSCLC_adenocarcinoma	p.Y220C (No)	GDSC	MIRA-1	301.61
SIDM00892	BRCA\|breast	p.M246I (No)	GDSC	MIRA-1	2262.5
SIDM00457	MM\|myeloma	p.R175H (No)	GDSC	MIRA-1	37.684
SIDM01027	ESCA\|oesophagus	p.E339* (No)	GDSC	MIRA-1	314.8
SIDM01027	ESCA\|oesophagus	p.H179R (No)	GDSC	MIRA-1	314.8
SIDM01040	OV\|ovary	p.H179D (No)	GDSC	MIRA-1	343.01
SIDM00659	GBM\|glioma	p.E286K (No)	GDSC	MIRA-1	120.21
SIDM00423	DLBC\|B_cell_lymphoma	p.R249G (No)	GDSC	MIRA-1	40.909
SIDM00423	DLBC\|B_cell_lymphoma	p.Y234N (No)	GDSC	MIRA-1	40.909
SIDM00105	OV\|ovary	p.R248Q (No)	GDSC	MIRA-1	358.65
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.K132Q (No)	GDSC	MIRA-1	6.9967
SIDM00317	KIRC\|kidney	p.D48fs*74 (No)	GDSC	MIRA-1	1834.1
SIDM00374	DLBC\|B_cell_lymphoma	p.V31I (Yes)	GDSC	MIRA-1	111.24
SIDM00237	LUAD\|lung_NSCLC_adenocarcinoma	p.R248Q (No)	GDSC	MIRA-1	2059.4
SIDM00278	ESCA\|oesophagus	p.R273L (No)	GDSC	MIRA-1	219.21
SIDM00278	ESCA\|oesophagus	p.Y234C (No)	GDSC	MIRA-1	219.21
SIDM00054	PAAD\|pancreas	p.R267W (No)	GDSC	MIRA-1	441.35
SIDM00496	THCA\|thyroid	p.P152L (No)	GDSC	MIRA-1	390.36
SIDM00944	COREAD\|large_intestine	p.S215N (No)	GDSC	MIRA-1	1476.3
SIDM01062	BRCA\|breast	p.R213* (No)	GDSC	MIRA-1	313.3
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S241F (No)	GDSC	MIRA-1	241.46
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.R181C (No)	GDSC	MIRA-1	51.252
SIDM00332	BRCA\|breast	p.K132R (No)	GDSC	MIRA-1	1333.8
SIDM00835	COREAD\|large_intestine	p.A159D (No)	GDSC	MIRA-1	693.48
SIDM00920	BRCA\|breast	p.R280T (No)	GDSC	MIRA-1	152.97
SIDM00693	BLCA\|bladder	p.E271K (No)	GDSC	MIRA-1	942.92
SIDM00531	PAAD\|pancreas	p.I255T (No)	GDSC	MIRA-1	338.03
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N345fs*24 (No)	GDSC	MIRA-1	41.359
SIDM00424	UNCLASSIFIED\|B_cell_leukemia	p.Y220C (No)	GDSC	MIRA-1	90.777
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.R273C (No)	GDSC	MIRA-1	62.486
SIDM00679	CESC\|cervix	p.E285K (No)	GDSC	MIRA-1	421.4
SIDM00679	CESC\|cervix	p.G245V (No)	GDSC	MIRA-1	421.4
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.S315fs*30 (No)	GDSC	MIRA-1	346.42
SIDM00848	UNCLASSIFIED\|rhabdomyosarcoma	p.A119fs*5 (No)	GDSC	MIRA-1	100.15
SIDM00900	MM\|myeloma	p.R273H (No)	GDSC	MIRA-1	9.9497
SIDM00579	NB\|neuroblastoma	p.F113L (No)	GDSC	MIRA-1	16.813
SIDM00118	COREAD\|large_intestine	p.R213* (No)	GDSC	MIRA-1	140.93
SIDM01248	THCA\|thyroid	p.I255S (No)	GDSC	MIRA-1	120.11
SIDM01109	UNCLASSIFIED\|soft_tissue_other	p.G245S (No)	GDSC	MIRA-1	242.4
SIDM01109	UNCLASSIFIED\|soft_tissue_other	p.M237K (No)	GDSC	MIRA-1	242.4
SIDM00356	LUAD\|lung_NSCLC_adenocarcinoma	p.E224D (No)	GDSC	MIRA-1	362
SIDM01149	SCLC\|lung_small_cell_carcinoma	p.R158L (No)	GDSC	MIRA-1	68.311
SIDM00832	COREAD\|large_intestine	p.T118fs*5 (No)	GDSC	MIRA-1	545.02
SIDM00860	HNSC\|head_and_neck	p.R248L (No)	GDSC	MIRA-1	240.82
SIDM00472	OV\|ovary	p.G244D (No)	GDSC	MIRA-1	298.06
SIDM00581	GBM\|glioma	p.N239_S240insN (No)	GDSC	MIRA-1	39.884
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.V216L (No)	GDSC	MIRA-1	266.78
SIDM00841	COREAD\|large_intestine	p.P309S (No)	GDSC	MIRA-1	2337
SIDM01188	PAAD\|pancreas	p.G360V (No)	GDSC	MIRA-1	2173.3
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.C238F (No)	GDSC	MIRA-1	31.956
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.Q165_S166insYKQ (No)	GDSC	MIRA-1	586.42
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.E11Q (Yes)	GDSC	MIRA-1	2.225
SIDM00901	UCEC\|endometrium	p.G389W (No)	GDSC	MIRA-1	65.639
SIDM01007	ALL\|lymphoblastic_leukemia	p.T125M (No)	GDSC	MIRA-1	82.935
SIDM00098	MESO\|mesothelioma	p.I232S (No)	GDSC	MIRA-1	168.85
SIDM00381	CESC\|cervix	p.V173L (No)	GDSC	MIRA-1	290.38
SIDM00312	MM\|myeloma	p.S261T (No)	GDSC	MIRA-1	94.018
SIDM00386	UNCLASSIFIED\|ewings_sarcoma	p.S215delS (No)	GDSC	MIRA-1	637.12
SIDM00292	SCLC\|lung_small_cell_carcinoma	p.V157fs*9 (No)	GDSC	MIRA-1	608.22
SIDM00498	COREAD\|large_intestine	p.V218L (No)	GDSC	MIRA-1	396.32
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.H233delH (No)	GDSC	MIRA-1	62.533
SIDM00885	BRCA\|breast	p.G108delG (No)	GDSC	MIRA-1	209.39
SIDM00946	ALL\|T_cell_leukemia	p.P301fs*44 (No)	GDSC	MIRA-1	70.626
SIDM00485	HNSC\|head_and_neck	p.A307V (No)	GDSC	MIRA-1	133.28
SIDM00054	PAAD\|pancreas	p.E171delE (No)	GDSC	MIRA-1	441.35
SIDM00195	UNCLASSIFIED\|ewings_sarcoma	p.K164E (No)	GDSC	MIRA-1	46.14
SIDM01055	LGG\|glioma	p.L265P (No)	GDSC	MIRA-1	159.45
SIDM00324	NB\|neuroblastoma	p.R283delR (No)	GDSC	MIRA-1	113.24
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.0 (No)	GDSC	MIRA-1	317.04
SIDM00333	UCEC\|endometrium	p.A74S (No)	GDSC	MIRA-1	249.98
SIDM01063	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y234fs*2 (No)	GDSC	MIRA-1	1336
SIDM00274	STAD\|stomach	p.E11Q (Yes)	GDSC	MIRA-1	416.45
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.G112_V122delGFLHSGTAKSV (No)	GDSC	MIRA-1	129.46
SIDM01088	UNCLASSIFIED\|endometrium	p.V218delV (No)	GDSC	MIRA-1	203.54
SIDM01052	OV\|ovary	p.C124R (No)	GDSC	MIRA-1	1914.3
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.P36L (Yes)	GDSC	MIRA-1	564.79
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.P36S (Yes)	GDSC	MIRA-1	564.79
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P301fs*44 (No)	GDSC	MIRA-1	115.42
SIDM00812	COREAD\|large_intestine	p.C238fs*21 (No)	GDSC	MIRA-1	2025.4
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.A347P (No)	GDSC	MIRA-1	155.35
SIDM00615	LIHC\|liver	p.E336fs*7 (No)	GDSC	MIRA-1	673.14
SIDM00670	PAAD\|pancreas	p.G187R (No)	GDSC	MIRA-1	3096.9
SIDM00520	MESO\|mesothelioma	p.Q192_H193delQH (No)	GDSC	MIRA-1	311.47
SIDM00120	PRAD\|prostate	p.P223L (No)	GDSC	MIRA-1	370.68
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.E286_E287delEE (No)	GDSC	MIRA-1	122.06
SIDM00702	LUAD\|lung_NSCLC_adenocarcinoma	p.Q16L (Yes)	GDSC	MIRA-1	124.08
SIDM00218	THCA\|thyroid	p.P223L (No)	GDSC	MIRA-1	2898.5
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E11Q (Yes)	GDSC	MIRA-1	232.35
SIDM00426	UNCLASSIFIED\|rhabdomyosarcoma	p.P152fs*14 (No)	GDSC	MIRA-1	135.59
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.K164N (No)	GDSC	MIRA-1	270.59
SIDM00291	SKCM\|melanoma	p.N268I (No)	GDSC	MIRA-1	324.6
SIDM00684	GBM\|glioma	p.P98L (No)	GDSC	MIRA-1	551.54
SIDM00826	COREAD\|large_intestine	p.Y103_R110delYQGSYGFR (No)	GDSC	MIRA-1	159.62
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V218delV (No)	GDSC	MIRA-1	1203
SIDM00113	KIRC\|kidney	p.L264R (No)	GDSC	MIRA-1	819.58
SIDM00540	HNSC\|head_and_neck	p.L188_P191delLAPP (No)	GDSC	MIRA-1	101.97
SIDM00693	BLCA\|bladder	p.K320N (No)	GDSC	MIRA-1	942.92
SIDM01087	SKCM\|melanoma	p.S166* (No)	GDSC	MIRA-1	76.742

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FSDLWKLL

Degron related mutations and impact score

Drug responses associated with TP53 mutations

All proteins holding degron of FSDLWKLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04637	Cellular tumor antigen p53	DEG_MDM2_SWIB_1	19:26	FSDLWKLL	MDM2	0.9897	More...