DegronMD - Q9Y4D2(DAGLA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E781D	TCGA-38-4632	LUAD	TCGA	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.5647
p.E781D	DO23858	LUAD	ICGC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.5647
p.P1005H	TCGA-AP-A059	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.1111
p.P1005H	DO41361	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.1111
p.A768V	TCGA-AP-A1E0	UCEC	TCGA	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1944
p.A768V	DO43154	UCEC	ICGC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1944
p.T1004K	TCGA-DD-AADC	LIHC	TCGA	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.1389
p.T1004K	DO52230	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.1389
p.S791C	TCGA-EB-A5VU	SKCM	TCGA	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.0556
p.S791C	DO47531	SKCM	ICGC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.0556
p.T1006M	TCGA-EY-A1GU	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.0833
p.T1006M	DO41518	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.0833
p.R773Q	DO3182	BRCA	ICGC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.6218
p.R773Q	SIDM02035	Colorectal Carcinoma	GDSC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.6218
p.R774W	DO232224	PBCA	ICGC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.8634
p.A767T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1667
p.A767T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1667
p.E769K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.2222
p.E769K	ACH-000904	Lung Cancer	CCLE	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.2222
p.E769K	ACH-001362	Lung Cancer	CCLE	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.2222
p.E769K	NCI-H1770	lung	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.2222
p.A778V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.5825
p.A778V	ACH-002222	Leukemia	CCLE	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.5825
p.A778V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation altering degron motif	0.5825
p.A767V	SIDM01105	Melanoma	GDSC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1667
p.A767V	ACH-000423	Skin Cancer	CCLE	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1667
p.A767V	SK-MEL-3	skin	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	773:781	Mutation rewiring degron network	0.1667
p.L1003P	ACH-000930	Breast Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.1667
p.L1003P	HCC1569	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	993:997	Mutation rewiring degron network	0.1667

Kaplan plot for DAGLA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DAGLA

UniProt ID: Q9Y4D2

Entrez ID: 747

Protein name: Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DAGLA in