DegronMD

Uniprot ID: Q9Y4D2

Source protein: Diacylglycerol lipase-alpha

Source gene: DAGLA

Class: DEG_APCC_DBOX_1

Location: 773:781

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 76.6

COIL: 0.8042

CONS_SCORE: 0.3172

DSS_SCORE: 0.3638

HELIX: 0.1194

FCONS_SCORE: 1.1315

RIG_SCORE: 0.751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E781D	TCGA-38-4632	LUAD	TCGA	RRAPLATME	DEG_APCC_DBOX_1	0.5647
p.E781D	DO23858	LUAD	ICGC	RRAPLATME	DEG_APCC_DBOX_1	0.5647
p.A768V	TCGA-AP-A1E0	UCEC	TCGA	RRAPLATME	DEG_APCC_DBOX_1	0.1944
p.A768V	DO43154	UCEC	ICGC	RRAPLATME	DEG_APCC_DBOX_1	0.1944
p.S791C	TCGA-EB-A5VU	SKCM	TCGA	RRAPLATME	DEG_APCC_DBOX_1	0.0556
p.S791C	DO47531	SKCM	ICGC	RRAPLATME	DEG_APCC_DBOX_1	0.0556
p.R773Q	DO3182	BRCA	ICGC	RRAPLATME	DEG_APCC_DBOX_1	0.6218
p.R773Q	SIDM02035	Colorectal Carcinoma	GDSC	RRAPLATME	DEG_APCC_DBOX_1	0.6218
p.R774W	DO232224	PBCA	ICGC	RRAPLATME	DEG_APCC_DBOX_1	0.8634
p.A767T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RRAPLATME	DEG_APCC_DBOX_1	0.1667
p.A767T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	0.1667
p.E769K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	RRAPLATME	DEG_APCC_DBOX_1	0.2222
p.E769K	ACH-000904	Lung Cancer	CCLE	RRAPLATME	DEG_APCC_DBOX_1	0.2222
p.E769K	ACH-001362	Lung Cancer	CCLE	RRAPLATME	DEG_APCC_DBOX_1	0.2222
p.E769K	NCI-H1770	lung	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	0.2222
p.A778V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RRAPLATME	DEG_APCC_DBOX_1	0.5825
p.A778V	ACH-002222	Leukemia	CCLE	RRAPLATME	DEG_APCC_DBOX_1	0.5825
p.A778V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	0.5825
p.A767V	SIDM01105	Melanoma	GDSC	RRAPLATME	DEG_APCC_DBOX_1	0.1667
p.A767V	ACH-000423	Skin Cancer	CCLE	RRAPLATME	DEG_APCC_DBOX_1	0.1667
p.A767V	SK-MEL-3	skin	COSMIC	RRAPLATME	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4D2	Diacylglycerol lipase-alpha	DEG_APCC_DBOX_1	773:781	RRAPLATME	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons