DegronMD

Uniprot ID: Q9H2A3

Source protein: Neurogenin-2

Source gene: NEUROG2

Class: DEG_SPOP_SBC_1

Location: 32:36

E3 ligase: SPOP

DEGRON score: 0.972

ASA_SCORE: 79.18

COIL: 0.9136

CONS_SCORE: 0.4733

DSS_SCORE: 0.6786

HELIX: 0.0682

FCONS_SCORE: 1.023

RIG_SCORE: 0.6365

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E40D	DO222798	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.A29V	DO229005	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	DO229047	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00608	Plasma Cell Myeloma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00570	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00194	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00584	Osteosarcoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00304	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00600	Thyroid Gland Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00157	Neuroblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00544	Neuroblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00362	Burkitt's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00296	Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00581	Glioblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00571	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01194	Hepatocellular Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00060	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00238	Ovarian Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00282	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00599	Osteosarcoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00054	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01146	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00240	Cervical Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01019	Acute Myeloid Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00618	Hepatocellular Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01217	Other Blood Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00566	Oral Cavity Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00613	Glioblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00579	Neuroblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00996	Thyroid Gland Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00302	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00604	Oral Cavity Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01372	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01695	Acute Myeloid Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01728	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01608	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01612	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01412	Oral Cavity Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM00167	Head and Neck Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01394	Kidney Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01464	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01432	Kidney Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01658	Unknown	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01413	Oral Cavity Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01774	Pancreatic Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.A29V	SIDM01443	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.25
p.S22L	DO233260	GACA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.0556
p.D38V	DO222702	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	0.2778
p.P32L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.7582
p.P32L	ACH-000924	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	0.7582
p.P32L	NCI-H2172	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.7582
p.A28V	SIDM00683	Prostate Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.A28V	SIDM00360	Other Solid Cancers	GDSC	PLSSS	DEG_SPOP_SBC_1	0.2222
p.A28V	QGP-1	pancreas	COSMIC	PLSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00763	Acetyl-CoA carboxylase 2	DEG_SPOP_SBC_1	103:107	PLSSS	SPOP	0.9873	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	239:243	PLSSS	SPOP	0.9749	More...
O60825	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	DEG_SPOP_SBC_1	469:473	PLSSS	SPOP	0.9968	More...
O75140	GATOR complex protein DEPDC5	DEG_SPOP_SBC_1	829:833	PLSSS	SPOP	0.9934	More...
O75152	Zinc finger CCCH domain-containing protein 11A	DEG_SPOP_SBC_1	685:689	PLSSS	SPOP	0.9688	More...
P04637	Cellular tumor antigen p53	DEG_SPOP_SBC_1	92:96	PLSSS	SPOP	0.9977	More...
P11388	DNA topoisomerase 2-alpha	DEG_SPOP_SBC_1	1389:1393	PLSSS	SPOP	0.9972	More...
P14316	Interferon regulatory factor 2	DEG_SPOP_SBC_1	312:316	PLSSS	SPOP	0.9872	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	185:189	PLSSS	SPOP	0.9793	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	574:578	PLSSS	SPOP	0.9943	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	288:292	PLSSS	SPOP	0.9368	More...
Q13470	Non-receptor tyrosine-protein kinase TNK1	DEG_SPOP_SBC_1	541:545	PLSSS	SPOP	0.9727	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	3634:3638	PLSSS	SPOP	0.9557	More...
Q2TBE0	CWF19-like protein 2	DEG_SPOP_SBC_1	388:392	PLSSS	SPOP	0.9997	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	77:81	PLSSS	SPOP	0.9962	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	114:118	PLSSS	SPOP	0.9937	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	1473:1477	PLSSS	SPOP	0.9884	More...
Q6ZN55	Zinc finger protein 574	DEG_SPOP_SBC_1	118:122	PLSSS	SPOP	0.9413	More...
Q6ZQX7	Protein LIAT1	DEG_SPOP_SBC_1	113:117	PLSSS	SPOP	0.961	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1434:1438	PLSSS	SPOP	0.9226	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	509:513	PLSSS	SPOP	0.9784	More...
Q8IVF2	Protein AHNAK2	DEG_SPOP_SBC_1	4735:4739	PLSSS	SPOP	0.6704	More...
Q8IZ21	Phosphatase and actin regulator 4	DEG_SPOP_SBC_1	174:178	PLSSS	SPOP	0.636	More...
Q8N684	Cleavage and polyadenylation specificity factor subunit 7	DEG_SPOP_SBC_1	247:251	PLSSS	SPOP	0.9926	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1354:1358	PLSSS	SPOP	0.959	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	248:252	PLSSS	SPOP	0.8247	More...
Q92993	Histone acetyltransferase KAT5	DEG_SPOP_SBC_1	133:137	PLSSS	SPOP	0.9685	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	573:577	PLSSS	SPOP	0.9968	More...
Q96MU7	YTH domain-containing protein 1	DEG_SPOP_SBC_1	73:77	PLSSS	SPOP	0.9922	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	478:482	PLSSS	SPOP	0.779	More...
Q9NS37	CREB/ATF bZIP transcription factor	DEG_SPOP_SBC_1	129:133	PLSSS	SPOP	0.9398	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	1112:1116	PLSSS	SPOP	0.9707	More...
Q9NXE4	Sphingomyelin phosphodiesterase 4	DEG_SPOP_SBC_1	244:248	PLSSS	SPOP	0.5515	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	1226:1230	PLSSS	SPOP	0.982	More...
Q9P0L1	Zinc finger protein with KRAB and SCAN domains 7	DEG_SPOP_SBC_1	365:369	PLSSS	SPOP	0.9637	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	615:619	PLSSS	SPOP	0.9976	More...
Q9P2B4	CTTNBP2 N-terminal-like protein	DEG_SPOP_SBC_1	405:409	PLSSS	SPOP	0.9931	More...
Q9P2P6	StAR-related lipid transfer protein 9	DEG_SPOP_SBC_1	1734:1738	PLSSS	SPOP	0.9258	More...
Q9UBC0	Hepatocyte nuclear factor 6	DEG_SPOP_SBC_1	181:185	PLSSS	SPOP	0.5617	More...
Q9UIU6	Homeobox protein SIX4	DEG_SPOP_SBC_1	311:315	PLSSS	SPOP	0.9014	More...
Q9ULK0	Glutamate receptor ionotropic, delta-1	DEG_SPOP_SBC_1	954:958	PLSSS	SPOP	0.9853	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1507:1511	PLSSS	SPOP	0.9967	More...
Q9UPX0	Protein turtle homolog B	DEG_SPOP_SBC_1	914:918	PLSSS	SPOP	0.9928	More...
Q9Y4D2	Diacylglycerol lipase-alpha	DEG_SPOP_SBC_1	993:997	PLSSS	SPOP	0.7658	More...
Q9Y5Y9	Sodium channel protein type 10 subunit alpha	DEG_SPOP_SBC_1	952:956	PLSSS	SPOP	0.9773	More...
Q8IZF5	Adhesion G-protein coupled receptor F3	DEG_SPOP_SBC_1	69:73	PLSSS	SPOP	0.8794	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	670:674	PLSSS	SPOP	0.9963	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	32:36	PLSSS	SPOP	0.972	More...
Q9UN71	Protocadherin gamma-B4	DEG_SPOP_SBC_1	429:433	PLSSS	SPOP	0.7211	More...
Q9Y5F8	Protocadherin gamma-B7	DEG_SPOP_SBC_1	431:435	PLSSS	SPOP	0.7253	More...
Q9Y5G0	Protocadherin gamma-B5	DEG_SPOP_SBC_1	427:431	PLSSS	SPOP	0.8178	More...
Q9Y5G2	Protocadherin gamma-B2	DEG_SPOP_SBC_1	431:435	PLSSS	SPOP	0.6125	More...
Q6ZMS4	Zinc finger protein 852	DEG_SPOP_SBC_1	141:145	PLSSS	SPOP	0.745	More...
Q6ZV89	SH2 domain-containing protein 5	DEG_SPOP_SBC_1	171:175	PLSSS	SPOP	0.9938	More...
Q8N9Z9	Lamin tail domain-containing protein 1	DEG_SPOP_SBC_1	35:39	PLSSS	SPOP	0.8742	More...
Q96N46	Tetratricopeptide repeat protein 14	DEG_SPOP_SBC_1	578:582	PLSSS	SPOP	0.8795	More...
Q96RY5	Protein cramped-like	DEG_SPOP_SBC_1	1056:1060	PLSSS	SPOP	0.9467	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	780:784	PLSSS	SPOP	0.9515	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	298:302	PLSSS	SPOP	0.9654	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSSS

Degron related mutations and impact score

Drug responses associated with NEUROG2 mutations

All proteins holding degron of PLSSS