DegronMD - Q2TBE0(CWF19L2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K382N	TCGA-43-3920	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation blocking ubiquitination signal	0.6111
p.K382N	DO26445	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation blocking ubiquitination signal	0.6111
p.L401S	TCGA-49-6743	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.L401S	DO26092	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.0833
p.L567V	TCGA-66-2785	LUSC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.3056
p.L567V	DO26520	LUSC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.3056
p.H380D	TCGA-A2-A3XZ	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1111
p.H380D	DO44137	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1111
p.G572R	TCGA-AG-A002	READ	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1667
p.R574I	TCGA-AX-A05Z	UCEC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1111
p.R574I	DO40884	UCEC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1111
p.E116D	TCGA-AX-A2HD	UCEC	TCGA	PSQTPDKE	DEG_SCF_FBW7_2	124:131	Mutation rewiring degron network	0.1111
p.E116D	DO42608	UCEC	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	124:131	Mutation rewiring degron network	0.1111
p.S554F	TCGA-BK-A0C9	UCEC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1944
p.S554F	DO41253	UCEC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1944
p.K132T	TCGA-BS-A0TC	UCEC	TCGA	PSQTPDKE	DEG_SCF_FBW7_2	124:131	Mutation rewiring degron network	0.3056
p.K132T	DO42400	UCEC	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	124:131	Mutation rewiring degron network	0.3056
p.G555V	TCGA-CV-A45W	HNSC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.2222
p.G555V	DO52060	HNSC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.2222
p.K575N	TCGA-OL-A6VR	BRCA	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation substituting flanking lysine	0.1944
p.K575N	DO219639	BRCA	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation substituting flanking lysine	0.1944
p.P388L	TCGA-W3-A824	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7582
p.P388L	DO51271	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation altering degron motif	0.7582
p.R556I	DO222718	COCA	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.25
p.T127N	DO228948	LICA	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	124:131	Mutation altering degron motif	0.7055
p.Q553K	DO229027	LICA	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1667
p.G571V	DO224563	LUSC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1944
p.H380Q	DO230544	PRAD	ICGC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1111
p.E131G	DO38404	STAD	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	124:131	Mutation altering degron motif	0.7199
p.G383S	SIDM00075	Non-Cancerous	GDSC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1944
p.G383S	SIDM00457	Plasma Cell Myeloma	GDSC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1944
p.G383S	SIDM00497	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.1944
p.D552N	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1389
p.D552N	ACH-000784	Esophageal Cancer	CCLE	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1389
p.D552N	KYSE-70	oesophagus	COSMIC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation rewiring degron network	0.1389
p.A394T	SIDM00534	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2778
p.A394T	ACH-000986	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2778
p.A394T	HT-115	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2778
p.P563S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation altering degron motif	0.6752
p.P563S	ACH-001737	Leukemia	CCLE	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation altering degron motif	0.6752
p.P563S	ACH-002222	Leukemia	CCLE	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation altering degron motif	0.6752
p.P563S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PVNTPGKS	DEG_SCF_FBW7_1	559:566	Mutation altering degron motif	0.6752
p.F386S	ACH-000296	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	388:392	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CWF19L2

UniProt ID: Q2TBE0

Entrez ID: 143884

Protein name: CWF19-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CWF19L2 in