DegronMD

Uniprot ID: Q2TBE0

Source protein: CWF19-like protein 2

Source gene: CWF19L2

Class: DEG_SCF_FBW7_1

Location: 559:566

E3 ligase: FBXW7

DEGRON score: 0.9932

ASA_SCORE: 70.2125

COIL: 0.7723

CONS_SCORE: 0.2694

DSS_SCORE: 0.6357

HELIX: 0.0346

FCONS_SCORE: 0.8841

RIG_SCORE: 0.6813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L567V	TCGA-66-2785	LUSC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	0.3056
p.L567V	DO26520	LUSC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.3056
p.G572R	TCGA-AG-A002	READ	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	0.1667
p.R574I	TCGA-AX-A05Z	UCEC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	0.1111
p.R574I	DO40884	UCEC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.1111
p.S554F	TCGA-BK-A0C9	UCEC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	0.1944
p.S554F	DO41253	UCEC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.1944
p.G555V	TCGA-CV-A45W	HNSC	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	0.2222
p.G555V	DO52060	HNSC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.2222
p.K575N	TCGA-OL-A6VR	BRCA	TCGA	PVNTPGKS	DEG_SCF_FBW7_1	0.1944
p.K575N	DO219639	BRCA	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.1944
p.R556I	DO222718	COCA	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.25
p.Q553K	DO229027	LICA	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.1667
p.G571V	DO224563	LUSC	ICGC	PVNTPGKS	DEG_SCF_FBW7_1	0.1944
p.D552N	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PVNTPGKS	DEG_SCF_FBW7_1	0.1389
p.D552N	ACH-000784	Esophageal Cancer	CCLE	PVNTPGKS	DEG_SCF_FBW7_1	0.1389
p.D552N	KYSE-70	oesophagus	COSMIC	PVNTPGKS	DEG_SCF_FBW7_1	0.1389
p.P563S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVNTPGKS	DEG_SCF_FBW7_1	0.6752
p.P563S	ACH-001737	Leukemia	CCLE	PVNTPGKS	DEG_SCF_FBW7_1	0.6752
p.P563S	ACH-002222	Leukemia	CCLE	PVNTPGKS	DEG_SCF_FBW7_1	0.6752
p.P563S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PVNTPGKS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TBE0	CWF19-like protein 2	DEG_SCF_FBW7_1	559:566	PVNTPGKS	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons