DegronMD

Uniprot ID: Q2TBE0

Source protein: CWF19-like protein 2

Source gene: CWF19L2

Class: DEG_SCF_FBW7_2

Location: 124:131

E3 ligase: FBXW7

DEGRON score: 0.5268

ASA_SCORE: 90.1375

COIL: 0.7385

CONS_SCORE: 0.2255

DSS_SCORE: 0.5539

HELIX: 0.2455

FCONS_SCORE: 0.8214

RIG_SCORE: 0.6597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E116D	TCGA-AX-A2HD	UCEC	TCGA	PSQTPDKE	DEG_SCF_FBW7_2	0.1111
p.E116D	DO42608	UCEC	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	0.1111
p.K132T	TCGA-BS-A0TC	UCEC	TCGA	PSQTPDKE	DEG_SCF_FBW7_2	0.3056
p.K132T	DO42400	UCEC	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	0.3056
p.T127N	DO228948	LICA	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	0.7055
p.E131G	DO38404	STAD	ICGC	PSQTPDKE	DEG_SCF_FBW7_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TBE0	CWF19-like protein 2	DEG_SCF_FBW7_2	124:131	PSQTPDKE	FBXW7	0.5268	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons