DegronMD - Q9UN71(PCDHGB4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T421M	TCGA-06-5416	GBM	TCGA	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1111
p.T421M	TCGA-DK-A6AW	BLCA	TCGA	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1111
p.T421M	DO48566	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1111
p.T421M	DO10880	GBM	ICGC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1111
p.S70L	TCGA-19-5956	GBM	TCGA	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation rewiring degron network	0.1111
p.S70L	DO9876	COAD	ICGC	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation rewiring degron network	0.1111
p.S70L	DO13863	GBM	ICGC	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation rewiring degron network	0.1111
p.E83G	TCGA-AP-A0LM	UCEC	TCGA	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation altering degron motif	0.7199
p.E83G	DO43306	UCEC	ICGC	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation altering degron motif	0.7199
p.R425W	TCGA-AP-A1DV	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222
p.R425W	DO43186	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222
p.G82R	TCGA-AX-A06H	UCEC	TCGA	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation altering degron motif	0.7568
p.G82R	DO43530	UCEC	ICGC	SAESGE	DEG_Kelch_Keap1_1	78:83	Mutation altering degron motif	0.7568
p.D424G	TCGA-BJ-A3PT	THCA	TCGA	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1944
p.D424G	DO40185	THCA	ICGC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.1944
p.V420I	DO228471	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0833
p.V420I	DO229016	COCA	ICGC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.0833
p.R425Q	SIDM01113	Other Sarcomas	GDSC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222
p.R425Q	ACH-000939	Sarcoma	CCLE	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222
p.R425Q	SK-UT-1	soft tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222
p.S434Y	SIDM01588	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.S434Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.3056
p.T437S	ACH-001097	Lymphoma	CCLE	PLSSS	DEG_SPOP_SBC_1	429:433	Mutation rewiring degron network	0.2222

Kaplan plot for PCDHGB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGB4

UniProt ID: Q9UN71

Entrez ID: 8641

Protein name: Protocadherin gamma-B4 (PCDH-gamma-B4) (Cadherin-20) (Fibroblast cadherin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGB4 in