DegronMD

Uniprot ID: Q9UN71

Source protein: Protocadherin gamma-B4

Source gene: PCDHGB4

Class: DEG_Kelch_Keap1_1

Location: 78:83

E3 ligase: KEAP1

DEGRON score: 0.8517

ASA_SCORE: 62.1667

COIL: 0.8073

CONS_SCORE: 0.6641

DSS_SCORE: 0.2766

HELIX: 0.02

FCONS_SCORE: 1.1153

RIG_SCORE: 0.7468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S70L	TCGA-19-5956	GBM	TCGA	SAESGE	DEG_Kelch_Keap1_1	0.1111
p.S70L	DO9876	COAD	ICGC	SAESGE	DEG_Kelch_Keap1_1	0.1111
p.S70L	DO13863	GBM	ICGC	SAESGE	DEG_Kelch_Keap1_1	0.1111
p.E83G	TCGA-AP-A0LM	UCEC	TCGA	SAESGE	DEG_Kelch_Keap1_1	0.7199
p.E83G	DO43306	UCEC	ICGC	SAESGE	DEG_Kelch_Keap1_1	0.7199
p.G82R	TCGA-AX-A06H	UCEC	TCGA	SAESGE	DEG_Kelch_Keap1_1	0.7568
p.G82R	DO43530	UCEC	ICGC	SAESGE	DEG_Kelch_Keap1_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons