DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
SAESGE
Uniprot ID:
Q9Y5G0
Source protein:
Protocadherin gamma-B5
Source gene:
PCDHGB5
Class:
DEG_Kelch_Keap1_1
Location:
78:83
E3 ligase:
KEAP1
DEGRON score:
0.858
ASA_SCORE:
61.5667
COIL:
0.8108
CONS_SCORE:
0.5981
DSS_SCORE:
0.2766
HELIX:
0.0188
FCONS_SCORE:
1.0704
RIG_SCORE:
0.7468
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y74C
GP5d
large_intestine
COSMIC
SAESGE
DEG_Kelch_Keap1_1
0.2222
Drug responses associated with PCDHGB5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SAESGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UN71
Protocadherin gamma-B4
DEG_Kelch_Keap1_1
78:83
SAESGE
KEAP1
0.8517
More...
Q9Y5G0
Protocadherin gamma-B5
DEG_Kelch_Keap1_1
78:83
SAESGE
KEAP1
0.858
More...