DegronMD - Q9Y6M4(CSNK1G3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V396I	TCGA-AX-A05Z	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.5965
p.V396I	DO40884	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.5965
p.T409N	TCGA-AX-A0J0	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.T409N	DO41133	UCEC	ICGC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.0556
p.N404S	TCGA-DF-A2KN	UCEC	TCGA	VVSST	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1944
p.W406L	DO228985	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1389
p.W406L	DO37896	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.1389
p.G391C	DO50826	LICA	ICGC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation rewiring degron network	0.2222
p.T399I	SIDM00789	Colorectal Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.7078
p.T399I	ACH-000997	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.7078
p.D395Y	ES-2	ovary	COSMIC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.7325
p.D396Y	ES-2	ovary	COSMIC	VVSST	DEG_SPOP_SBC_1	395:399	Mutation altering degron motif	0.7325

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons