DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SPOP_SBC_1

Location: 1739:1743

E3 ligase: SPOP

DEGRON score: 0.9233

ASA_SCORE: 80.06

COIL: 0.6014

CONS_SCORE: 0.2975

DSS_SCORE: 0.3905

HELIX: 0.0464

FCONS_SCORE: 1.0449

RIG_SCORE: 0.7858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1739G	TCGA-BR-8363	STAD	TCGA	VVSST	DEG_SPOP_SBC_1	0.7199
p.Y1742F	TCGA-EB-A5UM	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	0.7528
p.F1743L	TCGA-EB-A5UM	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	0.6981
p.F1750C	DO23174	LINC	ICGC	VVSST	DEG_SPOP_SBC_1	0.1389
p.R1747T	DO231127	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	0.2222
p.P1748L	DO222721	MELA	ICGC	VVSST	DEG_SPOP_SBC_1	0.3056
p.F1730L	DO47282	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.1944
p.Y1729F	DO47282	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.0556
p.P1746L	DO37406	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.P1746S	DO37406	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	0.25
p.R1733Q	SIDM01609	Endometrial Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	0.2778
p.R1733Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	184:188	VVSST	SPOP	0.9948	More...
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1230:1234	VVSST	SPOP	0.5329	More...
P21583	Kit ligand	DEG_SPOP_SBC_1	164:168	VVSST	SPOP	0.9767	More...
P51003	Poly	DEG_SPOP_SBC_1	615:619	VVSST	SPOP	0.7739	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1337:1341	VVSST	SPOP	0.7602	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1739:1743	VVSST	SPOP	0.9233	More...
Q14241	Elongin-A	DEG_SPOP_SBC_1	763:767	VVSST	SPOP	0.7077	More...
Q8N573	Oxidation resistance protein 1	DEG_SPOP_SBC_1	199:203	VVSST	SPOP	0.9992	More...
Q96B97	SH3 domain-containing kinase-binding protein 1	DEG_SPOP_SBC_1	469:473	VVSST	SPOP	0.9973	More...
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1	DEG_SPOP_SBC_1	161:165	VVSST	SPOP	0.5555	More...
Q9HCP0	Casein kinase I isoform gamma-1	DEG_SPOP_SBC_1	370:374	VVSST	SPOP	0.9967	More...
Q9NYB9	Abl interactor 2	DEG_SPOP_SBC_1	337:341	VVSST	SPOP	0.9646	More...
Q9Y6M4	Casein kinase I isoform gamma-3	DEG_SPOP_SBC_1	395:399	VVSST	SPOP	0.9966	More...
Q9NRJ5	Poly	DEG_SPOP_SBC_1	614:618	VVSST	SPOP	0.8298	More...
Q8NEM2	SHC SH2 domain-binding protein 1	DEG_SPOP_SBC_1	334:338	VVSST	SPOP	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons