DegronMD

Uniprot ID: O43294

Source protein: Transforming growth factor beta-1-induced transcript 1 protein

Source gene: TGFB1I1

Class: DEG_SCF_FBW7_1

Location: 31:37

E3 ligase: FBXW7

DEGRON score: 0.9826

ASA_SCORE: 91.4857

COIL: 0.9771

CONS_SCORE: 0.4051

DSS_SCORE: 0.8713

HELIX: 0.0084

FCONS_SCORE: 1.0182

RIG_SCORE: 0.5332

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E30K	TCGA-86-A4JF	LUAD	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.3056
p.R27H	TCGA-A5-A0G2	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.2222
p.R27C	TCGA-B5-A11G	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.2222
p.S21P	TCGA-B5-A1MR	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.0556
p.E30G	TCGA-B5-A3FA	UCEC	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.3056
p.P34S	TCGA-EE-A3AG	SKCM	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.6752
p.P35L	TCGA-QB-AA9O	SKCM	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.6471
p.T45M	DO9956	COAD	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.T45M	SNU-C2B	large_intestine	COSMIC	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.S36A	DO233869	GACA	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.7588
p.T45K	DO24527	LUAD	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.P25S	DO228429	MALY	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.2778
p.H23P	DO229499	SKCA	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.A35V	DO41235	UCEC	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.6936
p.T33P	ACH-000067	Brain Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	0.8142

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SCF_FBW7_1	31:37	PLTPPPS	FBXW7	0.9826	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SCF_FBW7_1	1759:1765	PLTPPPS	FBXW7	0.8914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons