DegronMD

Uniprot ID: Q5THJ4

Source protein: Intermembrane lipid transfer protein VPS13D

Source gene: VPS13D

Class: DEG_SCF_FBW7_1

Location: 1759:1765

E3 ligase: FBXW7

DEGRON score: 0.8914

ASA_SCORE: 92.0571

COIL: 0.9733

CONS_SCORE: 0.2771

DSS_SCORE: 0.6812

HELIX: 0.01

FCONS_SCORE: 1.108

RIG_SCORE: 0.6153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1759L	TCGA-ER-A199	SKCM	TCGA	PLTPPPS	DEG_SCF_FBW7_1	0.6471
p.P1759L	DO47395	SKCM	ICGC	PLTPPPS	DEG_SCF_FBW7_1	0.6471
p.P1766S	SIDM00545	Melanoma	GDSC	PLTPPPS	DEG_SCF_FBW7_1	0.3056
p.P1766S	ACH-000987	Skin Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	0.3056
p.P1766S	Mewo	skin	COSMIC	PLTPPPS	DEG_SCF_FBW7_1	0.3056
p.T1767I	SIDM00600	Thyroid Gland Carcinoma	GDSC	PLTPPPS	DEG_SCF_FBW7_1	0.7222
p.T1767I	SIDM00243	Other Solid Cancers	GDSC	PLTPPPS	DEG_SCF_FBW7_1	0.7222
p.I1773L	SIDM00865	Small Cell Lung Carcinoma	GDSC	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.I1773L	ACH-000530	Lung Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.I1773L	DMS-114	lung	COSMIC	PLTPPPS	DEG_SCF_FBW7_1	0.1111
p.P1763S	ACH-002669	Colon/Colorectal Cancer	CCLE	PLTPPPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SCF_FBW7_1	31:37	PLTPPPS	FBXW7	0.9826	More...
Q5THJ4	Intermembrane lipid transfer protein VPS13D	DEG_SCF_FBW7_1	1759:1765	PLTPPPS	FBXW7	0.8914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons