DegronMD - Q96J92(WNK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G133D	TCGA-17-Z031	LUAD	TCGA	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.25
p.S1039C	TCGA-23-1027	OV	TCGA	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation rewiring degron network	0.1944
p.S1039C	DO30540	OV	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation rewiring degron network	0.1944
p.A574G	TCGA-49-4487	LUAD	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1111
p.A574G	DO24780	LUAD	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1111
p.A547V	TCGA-94-8491	LUSC	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.0556
p.A547V	DO219174	LUSC	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.0556
p.L863V	TCGA-A2-A0YF	BRCA	TCGA	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.L863V	DO1761	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.3056
p.E559K	TCGA-A8-A08H	BRCA	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation altering degron motif	0.7022
p.E559K	DO5563	BRCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation altering degron motif	0.7022
p.Q878H	TCGA-AP-A059	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.0556
p.Q878H	DO41361	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.0556
p.F1134L	TCGA-AX-A2IO	UCEC	TCGA	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.2222
p.F1134L	TCGA-C5-A1MK	CESC	TCGA	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.2222
p.F1134L	DO6290	CESC	ICGC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.2222
p.F1134L	DO40800	UCEC	ICGC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.2222
p.S804L	TCGA-CD-8527	STAD	TCGA	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.S804L	DO47739	STAD	ICGC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.3056
p.E1126D	TCGA-CJ-4882	KIRC	TCGA	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation altering degron motif	0.5647
p.E1126D	DO16397	KIRC	ICGC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation altering degron motif	0.5647
p.E1052K	TCGA-CN-4723	HNSC	TCGA	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation rewiring degron network	0.2778
p.E1052K	DO14830	HNSC	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation rewiring degron network	0.2778
p.S1127N	TCGA-D8-A1J9	BRCA	TCGA	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation altering degron motif	0.7069
p.S1127N	DO2067	BRCA	ICGC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation altering degron motif	0.7069
p.H794D	TCGA-DD-A1EE	LIHC	TCGA	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.H794D	DO22857	LIHC	ICGC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.L1120F	TCGA-EK-A2RM	CESC	TCGA	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.1944
p.L1120F	DO49956	CESC	ICGC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.1944
p.A147V	TCGA-EO-A3AZ	UCEC	TCGA	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.2778
p.A147V	DO50078	UCEC	ICGC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.2778
p.L570F	TCGA-FW-A5DY	SKCM	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.2222
p.L570F	DO47257	SKCM	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.2222
p.P862L	TCGA-G2-A2ES	BLCA	TCGA	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2778
p.P862L	DO785	BLCA	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2778
p.E155K	TCGA-GF-A6C9	SKCM	TCGA	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.0556
p.E155K	DO51254	SKCM	ICGC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.0556
p.S805C	TCGA-LP-A4AV	CESC	TCGA	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.S805C	DO44275	CESC	ICGC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2778
p.F872L	TCGA-ND-A4WC	UCS	TCGA	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2222
p.P856S	TCGA-XF-A9SP	BLCA	TCGA	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.1111
p.P856S	DO223598	BLCA	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.1111
p.P1044H	DO228345	BRCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation altering degron motif	0.7694
p.G549V	DO44111	BRCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1111
p.S1045L	DO222391	BTCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation altering degron motif	0.6556
p.R152W	DO230323	COCA	ICGC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1389
p.P1047H	DO222755	COCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation altering degron motif	0.7694
p.P864T	DO50316	ESAD	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation altering degron motif	0.7031
p.S1045P	DO223068	ESCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation altering degron motif	0.5641
p.E1133K	DO233840	GACA	ICGC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.25
p.P875S	DO228589	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.1389
p.G1040C	DO229031	LICA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation rewiring degron network	0.2222
p.P551L	DO220891	MELA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1667
p.F872V	DO35442	PACA	ICGC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2222
p.F872V	SIDM00193	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2222
p.F872V	ACH-000991	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2222
p.F872V	SNU-81	large intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	864:868	Mutation rewiring degron network	0.2222
p.S552R	DO227850	PBCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1944
p.S136P	DO232224	PBCA	ICGC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation altering degron motif	0.6752
p.E153G	DO219881	SKCA	ICGC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.E153G	ACH-000615	Skin Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.H794Q	SIDM00232	Kidney Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.H794Q	NCC021	kidney	COSMIC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.R795T	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2222
p.R795T	ACH-000693	Esophageal Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2222
p.R795T	KYSE-180	oesophagus	COSMIC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.2222
p.S1140N	SIDM00781	Colorectal Carcinoma	GDSC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.0556
p.S1140N	ACH-001199	Colon/Colorectal Cancer	CCLE	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.0556
p.S1140N	SNU-C2B	large intestine	COSMIC	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.0556
p.P813T	SIDM01206	Neuroblastoma	GDSC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.P813T	ACH-002248	Neuroblastoma	CCLE	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.P813T	IMR-5	autonomic ganglia	COSMIC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.0556
p.P128L	SIDM00267	Biliary Tract Carcinoma	GDSC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.P128L	SIDM01464	Pancreatic Carcinoma	GDSC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.P128L	ACH-000498	Leukemia	CCLE	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.P128L	ACH-000502	Pancreatic Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.P128L	ACH-002312	Gallbladder Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.P128L	TGBC24TKB	biliary tract	COSMIC	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.1111
p.P908S	SIDM00190	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.P908S	SIDM00230	Small Cell Lung Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.P908S	ACH-002097	Skin Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.P908S	ACH-002145	Lung Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.P908S	IST-SL2	lung	COSMIC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.P908S	CP66-MEL	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.A920T	SIDM00333	Endometrial Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1667
p.A920T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1667
p.A920T	MFE-319	endometrium	COSMIC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1667
p.P551T	SIDM00151	Ovarian Carcinoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1667
p.P551T	ACH-000966	Ovarian Cancer	CCLE	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1667
p.P551T	IGROV-1	ovary	COSMIC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.1667
p.P555R	SIDM00032	Bladder Carcinoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.2778
p.P555R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.2778
p.P555R	SIDM00785	Acute Myeloid Leukemia	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	557:566	Mutation rewiring degron network	0.2778
p.S913F	SIDM00225	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7982
p.S913F	ACH-002143	Skin Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7982
p.S913F	IST-MEL1	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7982
p.G808A	SIDM01695	Acute Myeloid Leukemia	GDSC	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.G808A	ACH-000166	Leukemia	CCLE	AFSTS	DEG_SPOP_SBC_1	799:803	Mutation rewiring degron network	0.1944
p.S1121N	ACH-000994	Endometrial/Uterine Cancer	CCLE	SESSGE	DEG_Kelch_Keap1_1	1125:1130	Mutation rewiring degron network	0.2222
p.E1057A	ACH-001042	Ovarian Cancer	CCLE	PSTPQLT	DEG_SCF_FBW7_1	1044:1050	Mutation rewiring degron network	0.1389
p.Q154R	ACH-002027	Endometrial/Uterine Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	136:145	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WNK4

UniProt ID: Q96J92

Entrez ID: 65266

Protein name: Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WNK4 in