DegronMD

Uniprot ID: Q96J92

Source protein: Serine/threonine-protein kinase WNK4

Source gene: WNK4

Class: DEG_Kelch_Keap1_1

Location: 1125:1130

E3 ligase: KEAP1

DEGRON score: 0.7343

ASA_SCORE: 88.6333

COIL: 0.866

CONS_SCORE: 0.5358

DSS_SCORE: 0.4666

HELIX: 0.1222

FCONS_SCORE: 1.1323

RIG_SCORE: 0.5989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1134L	TCGA-AX-A2IO	UCEC	TCGA	SESSGE	DEG_Kelch_Keap1_1	0.2222
p.F1134L	TCGA-C5-A1MK	CESC	TCGA	SESSGE	DEG_Kelch_Keap1_1	0.2222
p.F1134L	DO6290	CESC	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.2222
p.F1134L	DO40800	UCEC	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.2222
p.E1126D	TCGA-CJ-4882	KIRC	TCGA	SESSGE	DEG_Kelch_Keap1_1	0.5647
p.E1126D	DO16397	KIRC	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.5647
p.S1127N	TCGA-D8-A1J9	BRCA	TCGA	SESSGE	DEG_Kelch_Keap1_1	0.7069
p.S1127N	DO2067	BRCA	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.7069
p.L1120F	TCGA-EK-A2RM	CESC	TCGA	SESSGE	DEG_Kelch_Keap1_1	0.1944
p.L1120F	DO49956	CESC	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.1944
p.E1133K	DO233840	GACA	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.25
p.S1140N	SIDM00781	Colorectal Carcinoma	GDSC	SESSGE	DEG_Kelch_Keap1_1	0.0556
p.S1140N	ACH-001199	Colon/Colorectal Cancer	CCLE	SESSGE	DEG_Kelch_Keap1_1	0.0556
p.S1140N	SNU-C2B	large_intestine	COSMIC	SESSGE	DEG_Kelch_Keap1_1	0.0556
p.S1121N	ACH-000994	Endometrial/Uterine Cancer	CCLE	SESSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52738	Zinc finger protein 140	DEG_Kelch_Keap1_1	79:84	SESSGE	KEAP1	0.5381	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_Kelch_Keap1_1	1125:1130	SESSGE	KEAP1	0.7343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons