DegronMD

Uniprot ID: P52738

Source protein: Zinc finger protein 140

Source gene: ZNF140

Class: DEG_Kelch_Keap1_1

Location: 79:84

E3 ligase: KEAP1

DEGRON score: 0.5381

ASA_SCORE: 78.1667

COIL: 0.8107

CONS_SCORE: 0.4221

DSS_SCORE: 0.3398

HELIX: 0.111

FCONS_SCORE: 0.9719

RIG_SCORE: 0.6804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C92F	DO228986	LICA	ICGC	SESSGE	DEG_Kelch_Keap1_1	0.1111
p.R73I	SIDM01045	Endometrial Carcinoma	GDSC	SESSGE	DEG_Kelch_Keap1_1	0.1667
p.R73I	EN	endometrium	COSMIC	SESSGE	DEG_Kelch_Keap1_1	0.1667
p.E70K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SESSGE	DEG_Kelch_Keap1_1	0.0833
p.E70K	ACH-000980	Lung Cancer	CCLE	SESSGE	DEG_Kelch_Keap1_1	0.0833
p.E70K	NCI-H1155	lung	COSMIC	SESSGE	DEG_Kelch_Keap1_1	0.0833
p.A82V	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	SESSGE	DEG_Kelch_Keap1_1	0.6936
p.R74I	EN	endometrium	COSMIC	SESSGE	DEG_Kelch_Keap1_1	0.1944
p.E71K	NCI-H1155	lung	COSMIC	SESSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52738	Zinc finger protein 140	DEG_Kelch_Keap1_1	79:84	SESSGE	KEAP1	0.5381	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_Kelch_Keap1_1	1125:1130	SESSGE	KEAP1	0.7343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons