DegronMD

Uniprot ID: Q96J92

Source protein: Serine/threonine-protein kinase WNK4

Source gene: WNK4

Class: DEG_SPOP_SBC_1

Location: 799:803

E3 ligase: SPOP

DEGRON score: 0.6668

ASA_SCORE: 85.96

COIL: 0.8954

CONS_SCORE: 0.4459

DSS_SCORE: 0.587

HELIX: 0.0682

FCONS_SCORE: 0.9413

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S804L	TCGA-CD-8527	STAD	TCGA	AFSTS	DEG_SPOP_SBC_1	0.3056
p.S804L	DO47739	STAD	ICGC	AFSTS	DEG_SPOP_SBC_1	0.3056
p.H794D	TCGA-DD-A1EE	LIHC	TCGA	AFSTS	DEG_SPOP_SBC_1	0.1944
p.H794D	DO22857	LIHC	ICGC	AFSTS	DEG_SPOP_SBC_1	0.1944
p.S805C	TCGA-LP-A4AV	CESC	TCGA	AFSTS	DEG_SPOP_SBC_1	0.2778
p.S805C	DO44275	CESC	ICGC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.H794Q	SIDM00232	Kidney Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.1944
p.H794Q	NCC021	kidney	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.1944
p.R795T	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.2222
p.R795T	ACH-000693	Esophageal Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.2222
p.R795T	KYSE-180	oesophagus	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.2222
p.P813T	SIDM01206	Neuroblastoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.0556
p.P813T	ACH-002248	Neuroblastoma	CCLE	AFSTS	DEG_SPOP_SBC_1	0.0556
p.P813T	IMR-5	autonomic_ganglia	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.0556
p.G808A	SIDM01695	Acute Myeloid Leukemia	GDSC	AFSTS	DEG_SPOP_SBC_1	0.1944
p.G808A	ACH-000166	Leukemia	CCLE	AFSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SPOP_SBC_1	862:866	AFSTS	SPOP	0.9864	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	915:919	AFSTS	SPOP	0.9877	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	242:246	AFSTS	SPOP	0.9947	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	799:803	AFSTS	SPOP	0.6668	More...
Q9H4B6	Protein salvador homolog 1	DEG_SPOP_SBC_1	59:63	AFSTS	SPOP	0.9968	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_SPOP_SBC_1	861:865	AFSTS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons