DegronMD

Uniprot ID: Q9H4B6

Source protein: Protein salvador homolog 1

Source gene: SAV1

Class: DEG_SPOP_SBC_1

Location: 59:63

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 78.98

COIL: 0.8866

CONS_SCORE: 0.3987

DSS_SCORE: 0.5211

HELIX: 0.0652

FCONS_SCORE: 0.9817

RIG_SCORE: 0.6577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S68L	TCGA-EE-A2GU	SKCM	TCGA	AFSTS	DEG_SPOP_SBC_1	0.1944
p.S68L	DO37639	SKCM	ICGC	AFSTS	DEG_SPOP_SBC_1	0.1944
p.S61L	SIDM00433	T-Lymphoblastic Leukemia	GDSC	AFSTS	DEG_SPOP_SBC_1	0.7667
p.S61L	ACH-000795	Leukemia	CCLE	AFSTS	DEG_SPOP_SBC_1	0.7667
p.S61L	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.7667
p.D65N	SIDM00324	Neuroblastoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.D65N	ACH-001674	Neuroblastoma	CCLE	AFSTS	DEG_SPOP_SBC_1	0.2778
p.D65N	TGW	autonomic_ganglia	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.I50V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.0833
p.I50V	ACH-000669	Lung Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.0833
p.I50V	SW900	lung	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SPOP_SBC_1	862:866	AFSTS	SPOP	0.9864	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	915:919	AFSTS	SPOP	0.9877	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	242:246	AFSTS	SPOP	0.9947	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	799:803	AFSTS	SPOP	0.6668	More...
Q9H4B6	Protein salvador homolog 1	DEG_SPOP_SBC_1	59:63	AFSTS	SPOP	0.9968	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_SPOP_SBC_1	861:865	AFSTS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons