DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: DEG_SPOP_SBC_1

Location: 915:919

E3 ligase: SPOP

DEGRON score: 0.9877

ASA_SCORE: 88.66

COIL: 0.9122

CONS_SCORE: 0.4426

DSS_SCORE: 0.5143

HELIX: 0.0466

FCONS_SCORE: 0.8688

RIG_SCORE: 0.7024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E923K	TCGA-D8-A1J9	BRCA	TCGA	AFSTS	DEG_SPOP_SBC_1	0.2222
p.S920C	TCGA-XF-AAN3	BLCA	TCGA	AFSTS	DEG_SPOP_SBC_1	0.3056
p.S919C	DO219053	BLCA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.7541
p.E922K	DO2067	BRCA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.25
p.I906V	DO23240	LINC	ICGC	AFSTS	DEG_SPOP_SBC_1	0.0833
p.R912Q	SIDM01522	B-Lymphoblastic Leukemia	GDSC	AFSTS	DEG_SPOP_SBC_1	0.25
p.I913L	ACH-001206	Bone Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SPOP_SBC_1	862:866	AFSTS	SPOP	0.9864	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	915:919	AFSTS	SPOP	0.9877	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	242:246	AFSTS	SPOP	0.9947	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	799:803	AFSTS	SPOP	0.6668	More...
Q9H4B6	Protein salvador homolog 1	DEG_SPOP_SBC_1	59:63	AFSTS	SPOP	0.9968	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_SPOP_SBC_1	861:865	AFSTS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons