DegronMD - Q9H4B6(SAV1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S68L	TCGA-EE-A2GU	SKCM	TCGA	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1944
p.S68L	DO37639	SKCM	ICGC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.1944
p.S61L	SIDM00433	T-Lymphoblastic Leukemia	GDSC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7667
p.S61L	ACH-000795	Leukemia	CCLE	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7667
p.S61L	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation altering degron motif	0.7667
p.D65N	SIDM00324	Neuroblastoma	GDSC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.D65N	ACH-001674	Neuroblastoma	CCLE	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.D65N	TGW	autonomic ganglia	COSMIC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.2778
p.I50V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0833
p.I50V	ACH-000669	Lung Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0833
p.I50V	SW900	lung	COSMIC	AFSTS	DEG_SPOP_SBC_1	59:63	Mutation rewiring degron network	0.0833

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons