DegronMD - O43157(PLXNB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S870L	TCGA-78-7161	LUAD	TCGA	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2222
p.G946D	TCGA-A5-A2K7	UCEC	TCGA	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.3056
p.R1469C	TCGA-A6-2686	COAD	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.8301
p.T382M	TCGA-AJ-A3BH	UCEC	TCGA	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.0556
p.T382M	DO41638	UCEC	ICGC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.0556
p.V1441M	TCGA-AJ-A3EK	UCEC	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.25
p.V1441M	TCGA-HU-A4G8	STAD	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.25
p.P1482H	TCGA-AP-A051	UCEC	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation rewiring degron network	0.1667
p.H941N	TCGA-AP-A1DK	UCEC	TCGA	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation altering degron motif	0.6312
p.T1429M	TCGA-AX-A1CE	UCEC	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.25
p.P81S	TCGA-BG-A0LX	UCEC	TCGA	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.5641
p.P81S	DO41919	UCEC	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.5641
p.L1468S	TCGA-BR-8487	STAD	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.6556
p.A860T	TCGA-BR-8487	STAD	TCGA	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.A860T	TCGA-NH-A5IV	COAD	TCGA	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.A860T	DO49095	COAD	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.A860T	DO47867	STAD	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.A860T	SIDM02049	Pancreatic Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.2778
p.D1422Y	TCGA-D3-A8GP	SKCM	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.0556
p.D853Y	TCGA-D9-A1JW	SKCM	TCGA	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0833
p.D853Y	DO37786	SKCM	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.0833
p.P1486S	TCGA-EB-A6QZ	SKCM	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation rewiring degron network	0.0556
p.R934W	TCGA-EE-A29M	SKCM	TCGA	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.1667
p.P1440S	TCGA-EE-A2GM	SKCM	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.2778
p.P1424H	TCGA-EE-A2M7	SKCM	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.1111
p.R931P	TCGA-H7-7774	HNSC	TCGA	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.0833
p.C1425Y	TCGA-PG-A6IB	UCEC	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.1389
p.L1433I	DO444	BLCA	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation altering degron motif	0.7174
p.R80C	DO7828	COAD	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.8301
p.R1444H	DO7810	COAD	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.1667
p.S864F	DO8658	COAD	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7982
p.P854S	DO8463	COAD	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1111
p.S866Y	DO224628	COCA	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.712
p.L1476V	DO223051	ESCA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.6765
p.T1470I	DO233258	GACA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.7078
p.E872K	DO22237	LGG	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1667
p.S384R	DO228948	LICA	ICGC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1111
p.L83M	DO228948	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.711
p.T67K	DO228986	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0833
p.D1471E	DO229029	LICA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.6758
p.F81L	DO229029	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6981
p.Q935K	DO229026	LICA	ICGC	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.1944
p.T867N	DO229036	LICA	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.3056
p.S76R	DO229035	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6316
p.S76R	ACH-000964	Leukemia	CCLE	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.6316
p.V390D	DO231573	LINC	ICGC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.2778
p.V403L	DO23180	LINC	ICGC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.2222
p.R867C	DO27596	LUSC	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.3056
p.I946V	DO27779	MALY	ICGC	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.3056
p.S82F	DO220911	MELA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7982
p.T1470N	DO50660	ORCA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.7055
p.P866S	DO35128	PACA	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.6752
p.K392T	DO51376	PRAD	ICGC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation altering degron motif	0.7306
p.G948W	DO47407	SKCM	ICGC	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.25
p.G863W	DO37971	SKCM	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.7825
p.Q1483K	DO37966	SKCM	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation rewiring degron network	0.1389
p.H1438Y	DO51276	SKCM	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation altering degron motif	0.7229
p.R865H	DO38727	STAD	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.8244
p.S1447P	DO48009	STAD	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.0833
p.L79S	DO47867	STAD	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation altering degron motif	0.7667
p.R408Q	DO229213	THCA	ICGC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.0833
p.L1477V	DO39910	THCA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation rewiring degron network	0.3056
p.R871W	DO42312	UCEC	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1944
p.V1460M	DO42568	UCEC	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation rewiring degron network	0.1111
p.A862V	DO42673	UCEC	ICGC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.5825
p.P93H	DO42673	UCEC	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	76:84	Mutation rewiring degron network	0.0833
p.H1433Y	SIDM01151	Hepatocellular Carcinoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation altering degron motif	0.6118
p.H1433Y	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation altering degron motif	0.6118
p.H1433Y	SIDM01447	Glioblastoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation altering degron motif	0.6118
p.P396S	SIDM00969	Ovarian Carcinoma	GDSC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation altering degron motif	0.6752
p.R389W	SIDM01197	Colorectal Carcinoma	GDSC	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.25
p.R389W	ACH-000722	Colon/Colorectal Cancer	CCLE	LEATPILE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.25
p.R1469H	SIDM00889	Cervical Carcinoma	GDSC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.8244
p.R1469H	ACH-001333	Cervical Cancer	CCLE	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.8244
p.R1469H	C-33-A	cervix	COSMIC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.8244
p.D874H	SIDM00920	Breast Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1111
p.D874H	ACH-000783	Breast Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1111
p.D874H	CAMA-1	breast	COSMIC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1111
p.L1430P	SIDM00220	Ovarian Carcinoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.2778
p.L1430P	ACH-000962	Ovarian Cancer	CCLE	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.2778
p.L1430P	ACH-001145	Ovarian Cancer	CCLE	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.2778
p.L1430P	OC-314	ovary	COSMIC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.2778
p.R931Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.0833
p.R931Q	ACH-000937	Leukemia	CCLE	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.0833
p.R931Q	PF-382	haematopoietic and lymphoid tissue	COSMIC	LHLFQD	LIG_APCC_ABBA_1	940:945	Mutation rewiring degron network	0.0833
p.T856M	ACH-001786	Colon/Colorectal Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation rewiring degron network	0.1667
p.L1440M	Ca9-22	upper aerodigestive tract	COSMIC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	1432:1438	Mutation rewiring degron network	0.2778
p.R865C	CML-T1	haematopoietic and lymphoid tissue	COSMIC	AFSTS	DEG_SPOP_SBC_1	862:866	Mutation altering degron motif	0.8301
p.R1474H	SNU-1040	large intestine	COSMIC	LRFSLGHVQ	DEG_APCC_DBOX_1	1468:1476	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXNB1

UniProt ID: O43157

Entrez ID: 5364

Protein name: Plexin-B1 (Semaphorin receptor SEP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXNB1 in