DegronMD

Uniprot ID: O43157

Source protein: Plexin-B1

Source gene: PLXNB1

Class: DEG_APCC_DBOX_1

Location: 1468:1476

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.878

ASA_SCORE: 47.0111

COIL: 0.2449

CONS_SCORE: 0.6888

DSS_SCORE: 0.3121

HELIX: 0.0087

FCONS_SCORE: 1.1849

RIG_SCORE: 0.7641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1469C	TCGA-A6-2686	COAD	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	0.8301
p.P1482H	TCGA-AP-A051	UCEC	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	0.1667
p.L1468S	TCGA-BR-8487	STAD	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	0.6556
p.P1486S	TCGA-EB-A6QZ	SKCM	TCGA	LRFSLGHVQ	DEG_APCC_DBOX_1	0.0556
p.L1476V	DO223051	ESCA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.6765
p.T1470I	DO233258	GACA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.7078
p.D1471E	DO229029	LICA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.6758
p.T1470N	DO50660	ORCA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.7055
p.Q1483K	DO37966	SKCM	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.1389
p.L1477V	DO39910	THCA	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.3056
p.V1460M	DO42568	UCEC	ICGC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.1111
p.R1469H	SIDM00889	Cervical Carcinoma	GDSC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.8244
p.R1469H	ACH-001333	Cervical Cancer	CCLE	LRFSLGHVQ	DEG_APCC_DBOX_1	0.8244
p.R1469H	C-33-A	cervix	COSMIC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.8244
p.R1474H	SNU-1040	large_intestine	COSMIC	LRFSLGHVQ	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_APCC_DBOX_1	1468:1476	LRFSLGHVQ	APC,CDC20,FZR1	0.878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons