DegronMD

Uniprot ID: O43157

Source protein: Plexin-B1

Source gene: PLXNB1

Class: LIG_APCC_ABBAyCdc20_2

Location: 1432:1438

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5202

ASA_SCORE: 65.7286

COIL: 0.3931

CONS_SCORE: 0.655

DSS_SCORE: 0.2972

HELIX: 0.0093

FCONS_SCORE: 1.129

RIG_SCORE: 0.7942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1441M	TCGA-AJ-A3EK	UCEC	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.25
p.V1441M	TCGA-HU-A4G8	STAD	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.25
p.T1429M	TCGA-AX-A1CE	UCEC	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.25
p.D1422Y	TCGA-D3-A8GP	SKCM	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1440S	TCGA-EE-A2GM	SKCM	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1424H	TCGA-EE-A2M7	SKCM	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.C1425Y	TCGA-PG-A6IB	UCEC	TCGA	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L1433I	DO444	BLCA	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.7174
p.R1444H	DO7810	COAD	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.1667
p.H1438Y	DO51276	SKCM	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.7229
p.S1447P	DO48009	STAD	ICGC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H1433Y	SIDM01151	Hepatocellular Carcinoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H1433Y	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H1433Y	SIDM01447	Glioblastoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.6118
p.L1430P	SIDM00220	Ovarian Carcinoma	GDSC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L1430P	ACH-000962	Ovarian Cancer	CCLE	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L1430P	ACH-001145	Ovarian Cancer	CCLE	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L1430P	OC-314	ovary	COSMIC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L1440M	Ca9-22	upper_aerodigestive_tract	COSMIC	RHHLYCE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	LIG_APCC_ABBAyCdc20_2	1432:1438	RHHLYCE	APC,CDC20,FZR1	0.5202	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons