DegronMD

Uniprot ID: O43157

Source protein: Plexin-B1

Source gene: PLXNB1

Class: LIG_APCC_ABBA_1

Location: 940:945

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7795

ASA_SCORE: 73.4833

COIL: 0.761

CONS_SCORE: 0.3381

DSS_SCORE: 0.2496

HELIX: 0.0968

FCONS_SCORE: 0.6894

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G946D	TCGA-A5-A2K7	UCEC	TCGA	LHLFQD	LIG_APCC_ABBA_1	0.3056
p.H941N	TCGA-AP-A1DK	UCEC	TCGA	LHLFQD	LIG_APCC_ABBA_1	0.6312
p.R934W	TCGA-EE-A29M	SKCM	TCGA	LHLFQD	LIG_APCC_ABBA_1	0.1667
p.R931P	TCGA-H7-7774	HNSC	TCGA	LHLFQD	LIG_APCC_ABBA_1	0.0833
p.Q935K	DO229026	LICA	ICGC	LHLFQD	LIG_APCC_ABBA_1	0.1944
p.I946V	DO27779	MALY	ICGC	LHLFQD	LIG_APCC_ABBA_1	0.3056
p.G948W	DO47407	SKCM	ICGC	LHLFQD	LIG_APCC_ABBA_1	0.25
p.R931Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LHLFQD	LIG_APCC_ABBA_1	0.0833
p.R931Q	ACH-000937	Leukemia	CCLE	LHLFQD	LIG_APCC_ABBA_1	0.0833
p.R931Q	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LHLFQD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	LIG_APCC_ABBA_1	940:945	LHLFQD	APC,CDC20,FZR1	0.7795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons