DegronMD

Uniprot ID: O43157

Source protein: Plexin-B1

Source gene: PLXNB1

Class: DEG_SCF_FBW7_2

Location: 392:399

E3 ligase: FBXW7

DEGRON score: 0.5483

ASA_SCORE: 47.1125

COIL: 0.4029

CONS_SCORE: 0.6054

DSS_SCORE: 0.3294

HELIX: 0.0148

FCONS_SCORE: 1.0546

RIG_SCORE: 0.8115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T382M	TCGA-AJ-A3BH	UCEC	TCGA	LEATPILE	DEG_SCF_FBW7_2	0.0556
p.T382M	DO41638	UCEC	ICGC	LEATPILE	DEG_SCF_FBW7_2	0.0556
p.S384R	DO228948	LICA	ICGC	LEATPILE	DEG_SCF_FBW7_2	0.1111
p.V390D	DO231573	LINC	ICGC	LEATPILE	DEG_SCF_FBW7_2	0.2778
p.V403L	DO23180	LINC	ICGC	LEATPILE	DEG_SCF_FBW7_2	0.2222
p.K392T	DO51376	PRAD	ICGC	LEATPILE	DEG_SCF_FBW7_2	0.7306
p.R408Q	DO229213	THCA	ICGC	LEATPILE	DEG_SCF_FBW7_2	0.0833
p.P396S	SIDM00969	Ovarian Carcinoma	GDSC	LEATPILE	DEG_SCF_FBW7_2	0.6752
p.R389W	SIDM01197	Colorectal Carcinoma	GDSC	LEATPILE	DEG_SCF_FBW7_2	0.25
p.R389W	ACH-000722	Colon/Colorectal Cancer	CCLE	LEATPILE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SCF_FBW7_2	392:399	LEATPILE	FBXW7	0.5483	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons